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Specifications, Properties, Uses, SDS of Calcium Levulinate USP BP Ph Eur Grade Manufacturer Supplier Exporter Wholesale & Small Packs, CAS Number 5743-49-7 for Dihydrate and 591-64-0 for Anhydrous. |
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Muby Chem Pvt. Ltd. is a several decades old group of companies, engaged in manufacturing, supplying, distributing, wholesale supplies of Calcium Levulinate for actual users, including retail or small pack supplies for research and development work.
We supply fine and speciality chemicals, pharmaceutical excipients, mineral fortifiers in chemically pure, analytical reagent grade, IP BP USP Ph Eur EP JP and other pharmaceutical grade monograph including FCC Food grade chemicals and Nutraceuticals at best prices. We and/or our associated units have all the facilities to supply as per cGMP standard observing good manufacturing practice and good laboratory practice. We can assure low microbial count and also offer a test certificate for the same. We maintain warehouses across USA, India, and UAE. Our group exports to USA, Canada, Mexico, Argentina, Brazil, Chile, Korea, Malaysia, Thailand, Indonesia, Europe, and several other parts of the world. We supply in wholesale container loads to small pack of few grams. Solid products may be specified for it size and shape as desired by the buyer.
Calcium Levulinate CAS Number 5743-49-7 for Dihydrate and 591-64-0 for Anhydrous
For Properties Specifications Uses of Calcium Levulinate Click Properties, Specifications, Uses, Price, Process of Calcium Levulinate Manufacturer.
For For SDS MSDS Sheet of Calcium Levulinate Click SDS Safety Data Sheet MSDS Sheet of Calcium Levulinate Manufacturer.
The Properties, Specifications, Monograph and Uses of Calcium Levulinate:
CAS Number: 5743-49-7 for Dihydrate and 591-64-0 for Anhydrous, EINECS EC Number: 209-725-9, Molecular Formula: C10-H14-Ca-O6•(H2O)2 for Dihydrate and C10-H14-Ca-O6 for Anhydrous, Molecular Weight: 306.32 for Dihydrate and 270.30 Anhydrous, HS Code ---**
Calcium levulinate is produced from a direct reaction between L- or levulinic acid levulose and calcium hydroxide. The resultant calcium levulinate formulation, when used as a calcium supplement, possesses a high calcium content. It is intended for use as a food fortifier, to fortify foods like sauces, condiments, beer, beverages, soft drinks, milk and milk products, soy milk and soy products with calcium nutrition. Calcium levulinate can be used alone, or with calcium lactate, calcium chloride, and other compounds, either for pharmaceutical tablets, capsules, or injections preparation.
Calcium Levulinate USP Grade Specifications:
C10H14CaO6-2H2O --- 306.32
C10H14CaO6 --- 270.30
Pentanoic acid, 4-oxo-, calcium salt (2:1), dihydrate;
Calcium levulinate (1:2) dihydrate CAS 5743-49-7
Anhydrous CAS 591-64-0
DEFINITION
Calcium Levulinate contains NLT 97.5% and NMT 100.5% of calcium levulinate (C10H14CaO6), calculated on the dried basis.
IDENTIFICATION
A. Identification Tests-General, Calcium: A 100 mg/mL solution meets the requirements.
B.
Sample solution: 0.5 g in 5 mL of water
Analysis: To the Sample solution add 5 mL of 1 N sodium hydroxide, and filter. To the filtrate add 5 mL of iodine.
Acceptance criteria: A precipitate of iodoform is produced.
ASSAY
Procedure
Sample: 600 mg of Calcium Levulinate
Blank: 150 mL of water containing 2 mL of 3 N hydrochloric acid
Titrimetric system
Mode: Direct titration
Titrant: 0.05 M edetate disodium
Endpoint detection: Visual
Analysis: Dissolve the Sample in 150 mL of water containing 2 mL of 3 N hydrochloric acid. While stirring with a magnetic stirrer, add 30 mL of Titrant from the titration burette. Add 15 mL of 1 N sodium hydroxide and 300 mg of hydroxy naphthol blue and continue the titration to a blue endpoint. Perform the Blank determination.
Calculate the percentage of calcium levulinate (C10H14CaO6) in the Sample taken:
Result = {[(V S- V B) x M x F]/W}x100
V S = Titrant volume consumed by the Sample (mL)
V B = Titrant volume consumed by the Blank (mL)
M = Titrant molarity (mM/mL)
F = equivalency factor, 270.3 mg/mM
W = Sample weight (mg)
Acceptance criteria: 97.5% to 100.5% on the dried basis.
Standard: 1.0 mL of 0.020 N hydrochloric acid
Sample: 1.0 g
Acceptance criteria: NMT 0.07%
Chloride and Sulfate, Sulfate:
Standard: 1.0 mL of 0.020 N sulfuric acid
Sample: 2.0 g
Acceptance criteria: NMT 0.05%
Reducing Sugars:
Sample: 0.50 g
Analysis: Dissolve the Sample in 10 mL of water, add 2 mL of 3 N hydrochloric acid, boil for about 2 min, and cool. Add 5 mL of sodium carbonate, allow to stand for 5 min, dilute with water to 20 mL, and filter. Add 5 mL of the clear filtrate to 2 mL of alkaline cupric tartrate, and boil for 1 min.
Acceptance criteria: No red precipitate is formed immediately.
Melting Range or Temperature: 119C to 125C
pH:
Sample solution: 100 mg/mL
Acceptance criteria: 7.0 to 8.5
Loss on Drying: Dry a sample at a pressure not exceeding 5 mm of mercury at 60C for 5 h: it loses 10.5% to 12.0% of its weight.
Packaging and Storage: Preserve in well-closed containers.
Calcium Levulinate Dihydrate BP Grade
Ph Eur
C10H14CaO6,2H2O -- 306.3 -- 5743-49-7
Action and use: Source of calcium.
DEFINITION
Calcium di(4-oxopentanoate) dihydrate.
Content: 98.0 per cent to 101.0 per cent (dried substance).
CHARACTERS
Appearance: White or almost white, crystalline powder.
Solubility: Freely soluble in water, very slightly soluble in ethanol (96 per cent), practically insoluble in methylene chloride.
IDENTIFICATION
First identification A, D, E.
Second identification B, C, D, E.
A. Infrared absorption spectrophotometry comparisonı calcium levulinate dihydrate CRS.
B. Thin-layer chromatography.
Test solution: Dissolve 60 mg of the substance to be examined in water and dilute to 1 ml with the same solvent.
Reference solution: Dissolve 60 mg of calcium levulinate dihydrate CRS in water and dilute to 1 ml with the same solvent.
Plate: TLC silica gel plate.
Mobile phase: concentrated ammonia, ethyl acetate, water, ethanol (96 per cent) (10:10:30:50 V/V/V/V).
Application: 10 μl.
Development: Over a path of 10 cm.
Drying: At 100C-105C for 20 min and allow to cool.
Detection: Spray with a 30 g/l solution of potassium permanganate. Dry in a current of warm air for about 5 min or until the spots become yellow. Examine in daylight.
Results: The principal spot in the chromatogram obtained with the test solution is similar in position, colour and size to the principal spot in the chromatogram obtained with the reference solution.
C. To 1 ml of solution S (see Tests), add 20 ml of a 2.5 g/l solution of dinitrophenylhydrazine in dilute hydrochloric acid. Allow to stand for 15 min. Filter, wash the precipitate with water. Dry the precipitate in an oven at 100C-105C. The melting point is 203C to 210C.
D. It gives reaction of calcium.
E. Loss on drying (see Tests).
TESTS
Solution S: Dissolve 10.0 g in carbon dioxide-free water R prepared from distilled water and dilute to 100.0 ml with the same solvent.
Appearance of solution: Solution S is clear and not more intensely coloured than reference solution.
pH: 6.8 to 7.8 for solution S.
Oxidisable substances: To 1 ml of solution S, add 10 ml of water, 1 ml of dilute sulphuric acid and 0.25 ml of a 3.0 g/l solution of potassium permanganate. Mix. After 5 min, the violet colour of the mixture is still visible.
Sucrose and reducing sugars: To 5 ml of solution S add 2 ml of hydrochloric acid and dilute to 10 ml with water. Heat to boiling for 5 min and allow to cool. Add 10 ml of sodium carbonate solution. Allow to stand for 5 min, dilute to 25 ml with water and filter. To 5 ml of the filtrate add 2 ml of cupri-tartaric solution and heat to boiling for 1 min. No red precipitate is formed.
Chlorides: Maximum 50 ppm.
Sulphates: Maximum 200 ppm.
Magnesium and alkali metals: Maximum 1.0 per cent.
To 10 ml of solution S, add 80 ml of water, 10 ml of ammonium chloride solution R and 1 ml of ammonia. Heat to boiling. To the boiling solution, add drop-wise 50 ml of warm ammonium oxalate solution. Allow to stand for 4 h, then dilute to 200 ml with water and filter. To 100 ml of the filtrate, add 0.5 ml of sulphuric acid. Evaporate to dryness on a water-bath and ignite to constant mass at 600±50C. The residue weighs a maximum of 5.0 mg.
Heavy metals: Maximum 10 ppm.
Loss on drying: 11.0 per cent to 12.5 per cent, determined on 0.200 g by drying at 105C.
Pyrogens: If intended for use in the manufacture of parenteral dosage forms without a further appropriate procedure for the removal of pyrogens, it complies with the test for pyrogens. Inject per kilogram of the rabbit's mass 4 ml of a solution containing per millilitre 50 mg of the substance to be examined.
The MSDS-SDS Hazard Statement of Calcium Levulinate:
Calcium Levulinate SDS, Safety Data Sheet
MSDS, Material Safety Data Sheet 31-Jul-21
Section 1: Chemical Product and Identification
Product Name & Other Names: 3-Acetylpropionic acid calcium salt, Pentanoic acid, 4-oxo-, calcium salt
CAS#: 5743-49-7 for Dihydrate and 591-64-0 for Anhydrous
EINECS EC-No.: 209-725-9
Molecular Weight: 306.32 for Dihydrate
Chemical Formula: C10-H14-Ca-O6-(H2O)2 for Dihydrate and C10-H14-Ca-O6 for Anhydrous
Relevant uses and uses advised against (if any): Laboratory and Industrial Manufacturing.
SUPPLIER: As per letterhead.
Section 2: Hazards Identification
GHS, Globally Harmonized System Classification in accordance with 29 CFR 1910
Classification according to Regulation (EC) No 1272/2008
Not a hazardous substance or mixture according to Regulation (EC) No. 1272/2008.
This substance is not classified as dangerous according to Directive 67/548/EEC.
Labeling according to GHS & Regulation (EC) No 1272/2008
GHS Label Elements NONE |
Signal Word: None
Precautionary statements:
P261: Avoid breathing dust/fume/gas/mist/vapors/spray.
P302+P352 - IF ON SKIN: Wash with plenty of soap and water.
P304 + P340 - IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338 - IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+313: If eye irritation persists get medical advice/attention.
Section 3: Composition and Information on Ingredients
Product Name & Other Names: 3-Acetylpropionic acid calcium salt, Pentanoic acid, 4-oxo-, calcium salt
CAS#: 5743-49-7 for Dihydrate and 591-64-0 for Anhydrous
EINECS EC-No.: 209-725-9
Section 4: First Aid Measures
Always seek medical attention after first aid measures are provided.
Eye Contact:In case of contact, immediately flush eyes with plenty of water for at least 15 minutes. Get medical attention.
Skin Contact: In case of contact, immediately flush skin with plenty of water. Cover the irritated skin with an emollient. Thoroughly clean shoes and clothes before reuse. Get medical attention.
Inhalation: If Calcium Levulinate is inhaled, remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical attention.
Ingestion: Do NOT induce vomiting unless directed to do so by medical personnel. Never give anything by mouth to an unconscious person. If large quantities of this material are swallowed, call a physician immediately.
Section 5: Fire and Explosion Data
Flammability of the Product: May be combustible at high temperature.
Auto-Ignition Temperature: Not available.
Products of Combustion: Some metallic oxides CO CO2 and fumes.
Fire Hazards in Presence of Various Substances: Slightly flammable in presence of heat. Non-flammable in presence of shocks.
Explosion Hazards in Presence of Various Substances: Slightly explosive in presence of open flames and sparks. Non-explosive in presence of shocks.
Fire Fighting Media and Instructions:
Small Fire: Use DRY chemical powder.
Large Fire: Use water spray, fog, or foam. Avoid water jet.
Extinguishing Media Not recommended: Avoid using solid water jet as it may scatter the fire.
Special Information: In the event of a fire, wear full protective clothing and NIOSH-approved self-contained breathing apparatus with full face piece operated in the pressure demand or other positive pressure mode. At high temperatures under fire conditions, it may produce toxic or irritating fumes. Fire-extinguishing work is done from the windward and the suitable fire-extinguishing method according to the surrounding situation is used. Uninvolved persons should evacuate to a safe place.
Section 6: Accidental Release Measures
Personal precautions, protective equipment, and emergency procedures: Ventilate area of leak or spill. Avoid breathing dust/fumes/gas/mist/vapors/spray. Use individual protective equipment (waterproof boots, suitable protective clothing, safety glasses, etc.). Restrict unprotected personnel from the area. Prevent any contact with hot surfaces. Do not approach facing the wind. Do not touch the spilled material.
Environmental precautions: Do not let the product enter drains, soil, or water sources.
Methods and materials used for containment cleanup procedures and Storage: Contain spilled material. Cover with an inert, non-combustible absorbent material, (e.g., sand, earth, diatomaceous earth, vermiculite). Vacuum or sweep-up and remove to an approved disposal container. Finish cleaning by spreading water on the contaminated surface and allow to evacuate as per law.
Section 7: Handling and Storage
Precautions for safe handling: Apply according to good manufacturing and industrial hygiene practices. Ensure proper ventilation. In case of insufficient ventilation, wear suitable respiratory equipment. Wash thoroughly after handling. Do not drink, eat, or smoke while handling. Avoid contact with skin, eyes, and clothing. Minimize dust generation. Avoid breathing dust/fumes/gas/mist/vapors/spray. Avoid contact with eyes, skin, and clothing. Keep container tightly closed. Avoid ingestion and inhalation. Use individual protective equipment (waterproof boots, suitable protective clothing, safety glasses, etc.). Prevent any contact with hot surfaces.
Conditions for safe storage, including any incompatibilities: Store in cool, dry, and ventilated area away from heat sources and protected from sunlight in tightly closed original container. Keep air contact to a minimum. Store protected from heat, sparks and ignition sources and incompatible materials. Avoid contact with skin and eyes. Avoid inhalation of dust/mist/vapor. Do not store with incompatible materials like strong oxidizing agents.
Section 8: Exposure Controls/Personal Protection
Exposure Limits: Not established.
Engineering Controls: Use process enclosures, local exhaust ventilation, or other engineering controls to keep airborne levels below recommended exposure limits. If user operations generate dust, fume, or mist, use ventilation to keep exposure to airborne contaminants below the exposure limit.
Ventilation System: A system of local and/or general exhaust is recommended to keep employee exposures as low as possible. Local exhaust ventilation is generally preferred because it can control the emissions of the contaminant at its source, preventing dispersion of it into the general work area.
Personal Respirators (NIOSH Approved): For conditions of use where exposure to dust or mist is apparent and engineering controls are not feasible, a particulate respirator may be worn. For emergencies or instances where the exposure levels are not known, use a full-face positive-pressure, air-supplied respirator.
Skin Protection: Wear protective gloves and clean body-covering clothing.
Eye Protection: Use chemical safety goggles and/or full-face shield where dusting or splashing of solutions is possible. Maintain eye wash fountain and quick-drench facilities in work area.
Other Control Measures: Maintain good housekeeping in work area. Dust deposits on floors and other surfaces may pick up moisture and cause the surfaces to become slippery and present safety hazards. Handle in accordance with good industrial hygiene and safety practice. Wash hands after handling.
Section 9: Physical and Chemical Properties
Appearance: White to off-white amorphous or crystalline powder
Odor: Burnt Sugar Type..
Odor threshold: Not available.
pH: Not available.
Relative density: Not available.
Melting Point: 123C
Initial boiling point and boiling range: Not available.
Flash point: Not available.
Auto-ignition temperature: Not available.
Decomposition temperature: Not available.
Upper/lower flammability or explosive limits: Not available.
Vapor pressure: Not available.
Vapor density: Not available.
Evaporation rate: Not available.
Flammability (solid, gas): Not available.
Partition coefficient: n-octanol/water: Not available.
Solubility(ies): Not available.
Viscosity: Not available.
Molecular Weight: 306.32 for Dihydrate
Chemical Formula: C10-H14-Ca-O6-(H2O)2 for Dihydrate and C10-H14-Ca-O6 for Anhydrous.
Section 10: Stability and Reactivity Data
Stability: It is stable.
Conditions of Instability: Excessive heat, dust generation
Incompatibility with various substances: Oxidizing Agents, heat, and sunlight.
Special Remarks on Reactivity: Releases water of crystallization when heated and decomposes.
Hazardous decomposition products formed under fire conditions: Carbon oxides, Calcium oxide.
Polymerization: Will not occur.
Section 11: Toxicological Information
Toxicity to Animals:
Oral-rat LD50: 6140 mg/kg
Oral Mouse LD50: 7,250 mg/kg
Carcinogenicity: No component of this product present at levels greater than or equal to 0.1% is identified as probable or confirmed human carcinogen by IARC, ACGIH, OSHA and NTP.
Mutagenic Effects: Not available.
Teratogenic Effects: Not available.
Environmental Toxicity: Not available.
Section 12: Ecological Information
Toxicity data: Not available.
Products of Biodegradation: Possibly hazardous short-term degradation products are not likely. However, long term degradation products may arise.
Persistence and Degradability: Unlikely to persist due to water solubility.
Mobility: Likely to be mobile due to water solubility.
Bioaccumulation/ Accumulation: No information available.
Results of PBT and vPvB assessment: No data available for assessment.
Section 13: Disposal Considerations
Waste Disposal: Waste must be disposed of in accordance legal regulations.
Section 14: Transport Information
Land Transport DOT USA, TDG Canada & ADR/RID Europe: Not dangerous goods.
Sea Transport IMO/IMDG: Not dangerous goods.
Air Transport ICAO/IATA: Not dangerous goods.
Section 15: Other Regulatory Information
USA:
SARA 311/312 Hazards: See section 2.
California Proposition 65: Not Listed.
Section 16 - Additional Information
DISCLAIMER: The information and recommendations set forth herein are presented in good faith and believed correct as of the date hereof. It is compiled from various sources, and it is not necessarily all inclusive nor fully adequate in every circumstance. In addition, these suggestions should not be confused with nor followed in violation of applicable laws, regulations, rules, or insurance requirements applicable. This SDS MSDS sheet is intended only as a guide to the appropriate precautionary handling of the material by a professionally trained person using this product. Individuals receiving the information must exercise their independent judgment in determining its appropriateness for a particular purpose. This shall not constitute a guarantee for any specific product features and shall not establish a legally valid contractual relationship. In no case shall our company be liable to loss or damages by the product user.
Calcium Levulinate Manufacturers, Suppliers, Exporters, Wholesalers:
King of Chemicals manufacturers
Plot No. 2900/46&47 + 2900/163to167, GIDC, Ankleshwar, Dist. Bharuch, India
India, USA, UAE
TEL: (Office) 91-22-23774610, 91-22-23723564
e-mail: info@kingofchemicals.com
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Our products are for industrial and laboratory use only. The user must test the material before use. We are not dispensing chemists or druggist and do not offer over the counter type (OTC) products for medical use by individuals.
We and our associates manufacture pure chemicals surpassing Monograph Specifications of Analytical Reagent Standards, British & European Pharmacopoeia BP Ph Eur EP Standard, US Pharmacopoeia USP NF Standard, Indian Pharmacopoeia IP Standard, Japan Pharmacopoeia JP Standard, FCC Food Grade Standard. |
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