Specifications, Uses, SDS of Calcium Citrate Manufacturers

	King of Chemicals
Specifications, Properties, Uses, SDS of Calcium Citrate USP FCC Food Grade Manufacturer Supplier Exporter Wholesale & Small Packs, CAS Number 5785-44-4.
King of Chemicals has several associated companies having accreditations like cGMP, GLP - FDA Approved Good Manufacturing Practice and Good Laboratory Practice of WHO standard, ISO-9001, ISO-14001, ISO/IEC 17025, ISO ISO-45000, HACCP, FSSC 220000, FSSAI, "REACH" Registered, Kosher & Halal Certified. DMF support can be made available if needed. We offer USP NF BP Ph Eur EP IP JP Analytical Reagent FCC Food Grade Chemicals & Nutraceuticals.

Muby Chem Pvt. Ltd. is a several decades old group of companies, engaged in manufacturing, supplying, distributing, wholesale supplies of Calcium Citrate for actual users, including retail or small pack supplies for research and development work.

We supply fine and speciality chemicals, pharmaceutical excipients, mineral fortifiers in chemically pure, analytical reagent grade, IP BP USP Ph Eur EP JP and other pharmaceutical grade monograph including FCC Food grade chemicals and Nutraceuticals at best prices. We and/or our associated units have all the facilities to supply as per cGMP standard observing good manufacturing practice and good laboratory practice. We can assure low microbial count and also offer a test certificate for the same. We maintain warehouses across USA, India, and UAE. Our group exports to USA, Canada, Mexico, Argentina, Brazil, Chile, Korea, Malaysia, Thailand, Indonesia, Europe, and several other parts of the world. We supply in wholesale container loads to small pack of few grams. Solid products may be specified for it size and shape as desired by the buyer.

CAS Number 5785-44-4 (tetrahydrate), EINECS EC Number 212-391-7, Molecular Weight 498.43 (anhydrous) and 570.49 (tetrahydrate), Molecular Formula: Ca3(C6H5O7)2-4H2O (tetrahydrate), HS Code 29181590

Calcium citrate is the calcium salt of citric acid. It is commonly used as a food additive with E-number E333, usually as a preservative, but sometimes for flavor. Calcium citrate is also used in dietary calcium supplements. It may be used to treat conditions caused by low calcium levels such as bone loss, weak bones, decreased activity of the parathyroid gland, and a certain muscle disease. It may also be used in certain patients to make sure they are getting enough calcium.

Calcium Citrate USP Grade Specifications:
C12H10Ca3O14-4H2O --- 570.49
1,2,3-Propanetricarboxylic acid, 2-hydroxy-, calcium salt (2:3), tetrahydrate;
Calcium citrate (3:2), tetrahydrate CAS 5785-44-4

DEFINITION
Calcium Citrate contains four molecules of water of hydration. When dried at 150C to constant weight, it contains NLT 97.5% and NMT 100.5% of Ca3(C6H5O7)2.

IDENTIFICATION
A.
Analysis: Dissolve 0.5 g in a mixture of 10 mL of water and 2.5 mL of 2 N nitric acid. Add 1 mL of mercuric sulfate TS, heat to boiling, and add 1 mL of potassium permanganate.
Acceptance criteria: A white precipitate is formed.
B.
Sample: 0.5 g of Calcium Citrate
Analysis: Ignite completely the Sample at as low a temperature as possible, cool, and dissolve the residue in dilute glacial acetic acid (1:10). Filter, and add 10 mL of ammonium oxalate to the filtrate.
Acceptance criteria: A voluminous white precipitate that is soluble in hydrochloric acid is formed.

ASSAY
Procedure
Sample solution: Dissolve 350 mg of Calcium Citrate, previously dried at 150C to constant weight, in 12 mL of 0.5 M hydrochloric acid, and dilute with water to about 100 mL.
Analysis: While stirring the Sample solution, add 30 mL of 0.05 M edetate disodium from a 50-mL burette. Add 15 mL of 1 N sodium hydroxide and 300 mg of hydroxy naphthol blue and continue the titration to a blue endpoint. Each mL of 0.05 M edetate disodium is equivalent to 8.307 mg of calcium citrate (Ca3&(C6H5O7)2).
Acceptance criteria: 97.5% to 100.5% on the dried basis

Calcium Citrate FCC Food Grade
Tricalcium Citrate
CH2(COO)C(OH)(COO)CH2COO2Ca3
Ca3(C6H5O7)2-4H2O Formula wt 570.50
INS: 333 CAS: 5785-44-4

DESCRIPTION
Calcium Citrate occurs as a fine, white powder. It is very slightly soluble in water, but it is insoluble in alcohol.

REQUIREMENTS
Identification:
A. Dissolve 500 mg of sample in 10 mL of water and 2.5 mL of 1.7 N nitric acid, add 1 mL of mercuric sulfate TS, heat to boiling, and then add potassium permanganate TS. A white precipitate forms.
B. Completely ignite 500 mg of sample at as low a temperature as possible, cool, and dissolve the residue in a mixture of 10 mL of water and 1 mL of glacial acetic acid. Filter, and add 10 mL of ammonium oxalate to the filtrate. A voluminous, white precipitate forms that is soluble in hydrochloric acid.
Assay: Not less than 97.5% and not more than 100.5% of Ca3(C6H5O7)2 after drying.
Fluoride: Not more than 0.003%.
Lead: Not more than 2 mg/kg.
Loss on Drying: Between 10.0% and 14.0%.

Calcium Citrate Tetrahydrate SDS, Safety Data Sheet
MSDS, Material Safety Data Sheet 31-Jul-21

Product Name & Other Trade Names: Calcium Citrate Tetrahydrate
Synonym: 1,2,3-propane tricarboxylic acid 2-hydroxy calcium salt, tetrahydrate / 2-hydroxy-1,2,3-propane tricarboxylic acid calcium salt, tetrahydrate / calcium citrate (3:2), tetrahydrate / lime citrate, tetrahydrate.
CAS Number: 5785-44-4
EINECS EC Code: 212-391-7
Chemical Formula: Ca3(C6H5O7)2-4H2O (tetrahydrate)
Molecular Weight: 570.49 g/mol (tetrahydrate) 498.43 g/mol (anhydrous)
Relevant uses and uses advised against (if any): Industrial Manufacturing.
Suppliers: As per letterhead.

GHS, Globally Harmonized System Classification in accordance with 29 CFR 1910
Classification according to Regulation (EC) No 1272/2008

Not a hazardous substance or mixture according to Regulation (EC) No. 1272/2008.
This substance is not classified as dangerous according to Directive 67/548/EEC.

Precautionary statements:
P261: Avoid breathing dust/fume/gas/mist/vapors/spray.
P262: Do not get in eyes, on skin, or on clothing.
P281: Use personal protective equipment as required.
P302+P352 - IF ON SKIN: Wash with plenty of soap and water.
P304 + P340 - IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338 - IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+313: If eye irritation persists get medical advice/attention.

Skin: Rinse with water. Soap may be used. Seek Medical Aid.
Eyes: Wash eyes with plenty of water for at least 15 minutes, lifting lids occasionally. Seek Medical Aid.
Inhalation: Remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen.
Ingestion: If swallowed, induce vomiting immediately after giving two glasses of water. Never give anything by mouth to an unconscious person.
Notes to Physician: Treat symptomatically.

Flammability of the Product: Non-flammable.
Auto-Ignition Temperature: Not applicable.
Flash Points: Not applicable.
Flammable Limits: Not applicable.
Products of Combustion: Calcium oxide, Fumes and Oxides of carbon.
Fire Fighting Media and Instructions: Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.
Extinguishing Media Not recommended: Avoid using solid water jet as it may scatter the fire.
Special Information: In the event of a fire, wear full protective clothing and NIOSH-approved self-contained breathing apparatus with full face piece operated in the pressure demand or other positive pressure mode. At high temperatures under fire conditions, it may produce toxic or irritating fumes. Fire-extinguishing work is done from the windward and the suitable fire-extinguishing method according to the surrounding situation is used. Uninvolved persons should evacuate to a safe place.

Personal precautions, protective equipment, and emergency procedures: Ventilate area of leak or spill. Avoid breathing dust/fumes/gas/mist/vapors/spray. Use individual protective equipment (waterproof boots, suitable protective clothing, safety glasses, etc.). Restrict unprotected personnel from the area. Prevent any contact with hot surfaces. Do not approach facing the wind. Do not touch the spilled material.
Environmental precautions: Do not let the product enter drains, soil, or water sources.
Methods and materials used for containment cleanup procedures and Storage: Contain spilled material. Cover with an inert, non-combustible absorbent material, (e.g. sand, earth, diatomaceous earth, vermiculite). Vacuum or sweep-up and remove to an approved disposal container. Finish cleaning by spreading water on the contaminated surface and allow to evacuate as per law.

Precautions for safe handling: Apply according to good manufacturing and industrial hygiene practices. Ensure proper ventilation. In case of insufficient ventilation, wear suitable respiratory equipment. Wash thoroughly after handling. Do not drink, eat, or smoke while handling. Avoid contact with skin, eyes, and clothing. Minimize dust generation. Avoid breathing dust/fumes/gas/mist/vapors/spray. Avoid contact with eyes, skin, and clothing. Keep container tightly closed. Avoid ingestion and inhalation. Use individual protective equipment (waterproof boots, suitable protective clothing, safety glasses, etc.). Prevent any contact with hot surfaces.
Conditions for safe storage, including any incompatibilities: Store in cool, dry, and ventilated area away from heat sources and protected from sunlight in tightly closed original container. Keep air contact to a minimum. Store protected from heat, sparks and ignition sources and incompatible materials. Avoid contact with skin and eyes. Avoid inhalation of dust/mist/vapor. Do not store with incompatible materials like strong oxidizing agents and acids.

Exposure Limits: This product does not contain any hazardous materials with occupational exposure limits established by the region-specific regulatory bodies. There is a blanket recommendation of 10 mg/m3 for inspirable dusts or mists when limits have not otherwise been established.
Engineering Controls: Use process enclosures, local exhaust ventilation, or other engineering controls to keep airborne levels below recommended exposure limits. If user operations generate dust, fume, or mist, use ventilation to keep exposure to airborne contaminants below the exposure limit.
Ventilation System: A system of local and/or general exhaust is recommended to keep employee exposures as low as possible. Local exhaust ventilation is generally preferred because it can control the emissions of the contaminant at its source, preventing dispersion of it into the general work area.
Personal Respirators (NIOSH Approved): For conditions of use where exposure to dust or mist is apparent and engineering controls are not feasible, a particulate respirator may be worn. For emergencies or instances where the exposure levels are not known, use a full-face positive-pressure, air-supplied respirator.
Skin Protection: Wear protective gloves and clean body-covering clothing.
Eye Protection: Use chemical safety goggles and/or full face shield where dusting or splashing of solutions is possible. Maintain eye wash fountain and quick-drench facilities in work area.
Other Control Measures: Maintain good housekeeping in work area. Dust deposits on floors and other surfaces may pick up moisture and cause the surfaces to become slippery and present safety hazards. Handle in accordance with good industrial hygiene and safety practice. Wash hands after handling.

Appearance: White to off-white crystals or powder.
Odor: Odorless.
Odor threshold: Not available.
pH (5% soln/water): 5 to 6.
Relative density: around 2.32
Melting point/freezing point: Not available.
Initial boiling point and boiling range: Not available.
Flash point: Not available.
Auto-ignition temperature: Not available.
Decomposition temperature : 100 - 120C
Upper/lower flammability or explosive limits: Not available.
Vapor pressure: Not available.
Vapor density: Not available.
Evaporation rate: Not available.
Flammability (solid, gas): Not available.
Partition coefficient: n-octanol/water: Not available.
Solubility: Practically insoluble in cold water.
Viscosity: Not available.
Chemical Formula: Ca3(C6H5O7)2-4H2O (tetrahydrate)
Molecular Weight: 570.49 g/mol (tetrahydrate) 498.43 g/mol (anhydrous)

Stability: It is stable.
Conditions of instability: Incompatible materials
Incompatibility with various substances: Oxidizing agents, acids. Heat.
Polymerization: Will not occur.

Toxicity to Animals: No acute toxicity information is available for this product.
Carcinogenic Effects: Not a reported carcinogen by IARC NTP ACGIH OSHA.
Mutagenic Effects: Not available.
Teratogenic Effects: Not available.
Developmental Toxicity: Not available.
Reproductive Effects: No information available.

Ecotoxicity: The product is not considered harmful to aquatic organisms or to cause long-term adverse effects in the environment. Not dangerous for the ozone layer.
Persistence and Degradability: No information available.
Mobility: No information available.
Bioaccumulation/ Accumulation: No information available.
Results of PBT and vPvB assessment: No data available for assessment.

Waste Disposal: Waste must be disposed of in accordance with federal, state, and local environmental control regulations.

Land Transport DOT USA, TDG Canada & ADR/RID Europe: Not dangerous goods.
Sea Transport IMO/IMDG: Not dangerous goods.
Air Transport ICAO/IATA: Not dangerous goods.

USA Regulations:
SARA 311/312 Hazardous Categorization: See section 2.
California Proposition 65: This product does not contain any Proposition 65 chemicals.

Calcium Citrate Manufacturers, Suppliers, Exporters, Wholesalers:

Plot No. 2900/46&47 + 2900/163to167, GIDC, Ankleshwar, Dist. Bharuch, India
India, USA, UAE
TEL: (Office) 91-22-23774610, 91-22-23723564

If I give you “My Word” Nobody can undo it.
If I sign an “Agreement” my Lawyer will undo it

Our products are for industrial and laboratory use only. The user must test the material before use. We are not dispensing chemists or druggist and do not offer over the counter type (OTC) products for medical use by individuals.

Specifications, Properties, Uses, SDS of Calcium Citrate USP FCC Food Grade Manufacturer Supplier Exporter Wholesale & Small Packs, CAS Number 5785-44-4.

Calcium Citrate Manufacturers, Suppliers, Exporters, Wholesalers: