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Specifications, Properties, Uses, SDS of Calcium Polystyrene Sulfonate or Calcium Polystyrene Sulphonate BP Ph Eur Grade Manufacturer Supplier Exporter Wholesale & Small Packs, CAS Number 37286-92-3. |
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We supply fine and speciality chemicals, pharmaceutical excipients, mineral fortifiers in chemically pure, analytical reagent grade, IP BP USP Ph Eur EP JP and other pharmaceutical grade monograph including FCC Food grade chemicals and Nutraceuticals at best prices. We and/or our associated units have all the facilities to supply as per cGMP standard observing good manufacturing practice and good laboratory practice. We can assure low microbial count and also offer a test certificate for the same. We maintain warehouses across USA, India, and UAE. Our group exports to USA, Canada, Mexico, Argentina, Brazil, Chile, Korea, Malaysia, Thailand, Indonesia, Europe, and several other parts of the world. We supply in wholesale container loads to small pack of few grams. Solid products may be specified for it size and shape as desired by the buyer.
Calcium Polystyrene Sulfonate or Calcium Polystyrene Sulphonate CAS Number 37286-92-3
For Properties Specifications Uses of Calcium Polystyrene Sulfonate or Calcium Polystyrene Sulphonate Click Properties, Specifications, Uses, Price, Process of Calcium Polystyrene Sulfonate or Calcium Polystyrene Sulphonate Manufacturer.
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The Properties, Specifications, Monograph and Uses of Calcium Polystyrene Sulfonate or Calcium Polystyrene Sulphonate:
CAS Number: CAS 37286-92-3, Molecular Formula: C8H7CaO3S+, Molecular Weight: 223.3, HS Code 29420090 or 29350090 or 39140000
Polystyrene sulfonates are a group of medications used to treat high blood potassium. Polystyrene sulfonates are useful because of their ion exchange properties. Calcium polystyrene sulfonate contains calcium atoms. This calcium is swapped for potassium in the body, particularly in the large intestine. This is its main use. Calcium polystyrene sulfonate is a cation exchange resin prepared in the calcium phase.
Calcium Polystyrene Sulfonate BP Ph Eur Grade:
Calcium Polystyrene Sulphonate
Action and use: Used in the treatment of hyperkalaemia.
DEFINITION
Calcium Polystyrene Sulfonate is a cation-exchange resin prepared in the calcium form containing not less than 6.5% w/w and not more than 9.5% w/w of calcium, calculated with reference to the dried substance. Each g exchanges not less than 1.3 mEq and not more than 2.0 mEq of potassium, calculated with reference to the dried substance.
CHARACTERISTICS
A cream to light brown, fine powder.
Practically insoluble in water and in ethanol (96%).
IDENTIFICATION
A. The infrared absorption spectrum is concordant with the reference spectrum of calcium polystyrene sulfonate.
B. Yields reaction C characteristic of calcium salts.
TESTS
Particle size: Not more than 1% w/w is retained on a 150-µm sieve. Use 20 g and sieve for 5 minutes.
Potassium: Not more than 0.1% of K when determined by atomic emission spectrophotometry, measuring at 766.5 nm and using a solution prepared in the following manner. To 1.1 g of the substance being examined add 5 mL of hydrochloric acid, heat to boiling, cool and add 10 mL of water. Filter, wash the filter and residue with water and dilute the filtrate and washings to 25 mL with water. Use potassium standard solution (100 ppm K), suitably diluted with water, to prepare the standard solutions.
Sodium: Not more than 0.1% of Na when determined by atomic emission spectrophotometry, measuring at 589.0 nm and using a solution prepared in the following manner. To 1.1 g of the substance being examined add 5 mL of hydrochloric acid, heat to boiling, cool and add 10 mL of water. Filter, wash the filter and residue with water and dilute the filtrate and washings to 25 mL with water. Use sodium solution (200 ppm Na), suitably diluted with water, to prepare the standard solutions.
Arsenic: 1 g complies with the limit test for arsenic, 1 ppm.
Styrene: Carry out the method for liquid chromatography. To pass the test --- (1 ppm).
Potassium exchange capacity: To 3 g of the substance being examined in a dry 250 mL glass-stoppered flask add 100 mL of a solution containing 0.7455% w/v of potassium chloride and 0.4401% w/v of potassium hydrogen carbonate in water (solution A), stopper and shake for 15 minutes. Filter and dilute 2 mL of the filtrate to 1000 mL with water. Determine the concentration of unbound potassium in this solution by atomic emission spectrophotometry, measuring at 766.5 nm and using solution A suitably diluted with water, to prepare the standard solutions. Calculate the potassium exchange capacity of the substance being examined in milliequivalents taking the concentration of potassium in solution A as 144 milliequivalents of K per liter.
Loss on drying: When dried at 70C at a pressure not exceeding 0.7 kPa for 16 hours, loses not more than 8.0% of its weight. Use 2 g.
Microbial contamination: Carry out a quantitative evaluation for Enterobacteria and certain other Gram-negative bacteria, Appendix XVI B1. 0.01 g of the substance being examined gives a negative result, Table I (most probable number of bacteria per gram fewer than 100).
ASSAY
For calcium: Carefully heat 1 g in a platinum crucible until a white ash is obtained and dissolve in 10 mL of& 2M hydrochloric acid with the aid of heat. Transfer the resulting solution to a conical flask using 20 mL of water. Add 50 mL of 0.05M disodium edetate, 20 mL of ammonia buffer pH 10.9 and titrate the excess of disodium edetate with 0.02M zinc sulfate, using a 0.5% w/v solution of mordant black 11 in ethanol (96%) as indicator to a red purple end point. Each mL of 0.05M disodium edetate is equivalent to 2.004 mg of Ca.
Calcium Polystyrene Sulfonate should be kept in an airtight container.
The MSDS-SDS Hazard Statement of Calcium Polystyrene Sulfonate or Calcium Polystyrene Sulphonate:
Calcium Polystyrene Sulphonate or Calcium Polystyrene Sulfonate
SDS, Safety Data Sheet
MSDS, Material Safety Data Sheet 31-Jul-21
Section 1: Chemical Product and Company Identification
Product Name & Other Names: Calcium Polystyrene Sulfonate or Calcium Polystyrene Sulphonate.
CAS #: 37286-92-3
Molecular Formula: C8H7CaO3S+
Molecular Weight: 223.3
Relevant uses and uses advised against (if any): Industrial use only.
Supplier: As per letterhead.
Section 2: Hazards Identification
GHS, Globally Harmonized System Classification in accordance with 29 CFR 1910
Classification according to Regulation (EC) No 1272/2008
Not a hazardous substance or mixture according to Regulation (EC) No. 1272/2008.
This substance is not classified as dangerous according to Directive 67/548/EEC.
Labeling according to GHS & Regulation (EC) No 1272/2008
GHS Label Elements NONE |
Signal Word: None
Precautionary statements:
P261: Avoid breathing dust/fume/gas/mist/vapors/spray.
P262: Do not get in eyes, on skin, or on clothing.
P281: Use personal protective equipment as required.
P302+P352 - IF ON SKIN: Wash with plenty of soap and water.
P304 + P340 - IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338 - IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+313: If eye irritation persists get medical advice/attention.
Section 3: Composition and Information on Ingredients
Product Name & Other Names: Calcium Polystyrene Sulfonate or Calcium Polystyrene Sulphonate
CAS #: 37286-92-3
% by Weight: 90-100%. Mainly water as other substance.
Section 4: First Aid Measures
Always seek medical advice after the first aid treatment.
First aid: Wash exposed area with soap and water.
Eyes: Wash eyes with plenty of water for at least 15 minutes, lifting lids occasionally. Seek Medical Aid.
Inhalation: Remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen.
Ingestion: If swallowed, induce vomiting immediately after giving two glasses of water. Never give anything by mouth to an unconscious person.
Section 5: Fire and Explosion Data
Flammability of the Product: Non-flammable.
Products of Combustion: Calcium oxide with oxides of sulfur, carbon, and fumes.
Extinguisher Media: Use media suitable to extinguish surrounding fire. Use alcohol-resistant foam, dry chemical, or carbon dioxide.
Extinguishing Media Not recommended: Avoid using solid water jet as it may scatter the fire.
Special Information: In the event of a fire, wear full protective clothing and NIOSH-approved self-contained breathing apparatus with full face piece operated in the pressure demand or other positive pressure mode. At high temperatures under fire conditions, it may produce toxic or irritating fumes. Fire-extinguishing work is done from the windward and the suitable fire-extinguishing method according to the surrounding situation is used. Uninvolved persons should evacuate to a safe place.
Section 6: Accidental Release Measures
Personal precautions, protective equipment, and emergency procedures: Ventilate area of leak or spill. Avoid breathing dust/fumes/gas/mist/vapors/spray. Use individual protective equipment (waterproof boots, suitable protective clothing, safety glasses, etc.). Restrict unprotected personnel from the area. Prevent any contact with hot surfaces. Do not approach facing the wind. Do not touch the spilled material.
Environmental precautions: Do not let the product enter drains, soil, or water sources.
Methods and materials used for containment cleanup procedures and Storage: Contain spilled material. Cover with an inert, non-combustible absorbent material, (e.g., sand, earth, diatomaceous earth, vermiculite). Vacuum or sweep-up and remove to an approved disposal container. Finish cleaning by spreading water on the contaminated surface and allow to evacuate as per law.
Section 7: Handling and Storage
Precautions for safe handling: Apply according to good manufacturing and industrial hygiene practices. Ensure proper ventilation. In case of insufficient ventilation, wear suitable respiratory equipment. Wash thoroughly after handling. Do not drink, eat, or smoke while handling. Avoid contact with skin, eyes, and clothing. Minimize dust generation. Avoid breathing dust/fumes/gas/mist/vapors/spray. Avoid contact with eyes, skin, and clothing. Keep container tightly closed. Avoid ingestion and inhalation. Use individual protective equipment (waterproof boots, suitable protective clothing, safety glasses, etc.). Prevent any contact with hot surfaces.
Conditions for safe storage, including any incompatibilities: Store in cool, dry, and ventilated area away from heat sources and protected from sunlight in tightly closed original container. Keep air contact to a minimum. Store protected from heat, sparks and ignition sources and incompatible materials. Avoid contact with skin and eyes. Avoid inhalation of dust/mist/vapor. Do not store with incompatible materials like strong oxidizing agents and acids. Avoid moisture.
Section 8: Exposure Controls/Personal Protection
Exposure Limits: This product does not contain any hazardous materials with occupational exposure limits established by the region-specific regulatory bodies. There is a blanket recommendation of 10 mg/m3 for inspirable dusts or mists when limits have not otherwise been established.
Engineering Controls: Use process enclosures, local exhaust ventilation, or other engineering controls to keep airborne levels below recommended exposure limits. If user operations generate dust, fume, or mist, use ventilation to keep exposure to airborne contaminants below the exposure limit.
Ventilation System: A system of local and/or general exhaust is recommended to keep employee exposures as low as possible. Local exhaust ventilation is generally preferred because it can control the emissions of the contaminant at its source, preventing dispersion of it into the general work area.
Personal Respirators (NIOSH Approved): For conditions of use where exposure to dust or mist is apparent and engineering controls are not feasible, a particulate respirator may be worn. For emergencies or instances where the exposure levels are not known, use a full-face positive-pressure, air-supplied respirator.
Skin Protection: Wear protective gloves and clean body-covering clothing.
Eye Protection: Use chemical safety goggles and/or full-face ashield where dusting or splashing of solutions is possible. Maintain eye wash fountain and quick-drench facilities in work area.
Other Control Measures: Maintain good housekeeping in work area. Dust deposits on floors and other surfaces may pick up moisture and cause the surfaces to become slippery and present safety hazards. Handle in accordance with good industrial hygiene and safety practice. Wash hands after handling.
Section 9: Physical and Chemical Properties
Appearance: Cream to light brown solid.
Odor: Not available.
Odor threshold: Not available.
pH: Not available.
Relative density: around 0.7 to 0.8
Melting point/freezing point: Not available.
Initial boiling point and boiling range: Not available.
Flash point: Not available.
Auto-ignition temperature: Not available.
Decomposition temperature: Not available.
Upper/lower flammability or explosive limits: Not available.
Vapor pressure: Not available.
Vapor density: Not available.
Evaporation rate: Not available.
Flammability (solid, gas): Not available.
Partition coefficient: n-octanol/water: Not available.
Solubility(ies): Insoluble in cold water and alcohol.
Viscosity: Not available.
Molecular Formula: C8H7CaO3S+
Molecular Weight: 223.3
Section 10: Stability and Reactivity Data
Stability: Stable under ordinary conditions of use and storage.
Conditions of Instability: Incompatible materials
Incompatibility with various substances: Reactive with oxidizing agents.
Corrosivity: Non-corrosive in presence of glass.
Polymerization: Will not occur.
Section 11: Toxicological Information
Toxicity to Animals: LD50 (Oral) Rat >5000 mg/kg
Carcinogenicity: Not available.
Mutagenic Effects: Not available.
Teratogenic Effects: Not available.
Developmental Toxicity: Not available.
Reproductive Effects: No information available.
Section 12: Ecological Information
Ecotoxicity: The product is not expected to be harmful to marine life.
Persistence and Degradability: No information available.
Mobility: No information available.
Bioaccumulation/ Accumulation: No information available.
Results of PBT and vPvB assessment: No data available for assessment.
Section 13: Disposal Considerations
Waste Disposal: Waste must be disposed of in accordance with federal, state, and local environmental control regulations.
Section 14: Transport Information
Land transport DOT USA, TDG Canada & ADR/RID Europe: Not dangerous goods.
Sea Transport IMDG/IMO: Not dangerous goods.
Air Transport IATA/ICAO: Not dangerous goods.
Section 15: Other Regulatory Information
USA Regulations:
California Proposition 65: Not listed.
SARA 311/312 Hazards: See section 2.
Section 16 - Additional Information
DISCLAIMER: The information and recommendations set forth herein are presented in good faith and believed correct as of the date hereof. It is compiled from various sources, and it is not necessarily all inclusive nor fully adequate in every circumstance. In addition, these suggestions should not be confused with nor followed in violation of applicable laws, regulations, rules, or insurance requirements applicable. This SDS MSDS sheet is intended only as a guide to the appropriate precautionary handling of the material by a professionally trained person using this product. Individuals receiving the information must exercise their independent judgment in determining its appropriateness for a particular purpose. This shall not constitute a guarantee for any specific product features and shall not establish a legally valid contractual relationship. In no case shall our company be liable to loss or damages by the product user.
Calcium Polystyrene Sulfonate or Calcium Polystyrene Sulphonate Manufacturers, Suppliers, Exporters, Wholesalers:
King of Chemicals manufacturers
Plot No. 2900/46&47 + 2900/163to167, GIDC, Ankleshwar, Dist. Bharuch, India
India, USA, UAE
TEL: (Office) 91-22-23774610, 91-22-23723564
e-mail: info@kingofchemicals.com
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