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Specifications, Properties, Uses, SDS of Tricalcium Phosphate or Calcium Phosphate Tribasic USP NF BP Ph Eur FCC Food Grade Manufacturer Supplier Exporter Wholesale & Small Packs, CAS Number 7758-87-4 or 1306-06-5 or 12167-74-7 or 62974-97-4. |
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Muby Chem Pvt. Ltd. is a several decades old group of companies, engaged in manufacturing, supplying, distributing, wholesale supplies of Tricalcium Phosphate or Calcium Phosphate Tribasic for actual users, including retail or small pack supplies for research and development work.
We supply fine and speciality chemicals, pharmaceutical excipients, mineral fortifiers in chemically pure, analytical reagent grade, IP BP USP Ph Eur EP JP and other pharmaceutical grade monograph including FCC Food grade chemicals and Nutraceuticals at best prices. We and/or our associated units have all the facilities to supply as per cGMP standard observing good manufacturing practice and good laboratory practice. We can assure low microbial count and also offer a test certificate for the same. We maintain warehouses across USA, India, and UAE. Our group exports to USA, Canada, Mexico, Argentina, Brazil, Chile, Korea, Malaysia, Thailand, Indonesia, Europe, and several other parts of the world. We supply in wholesale container loads to small pack of few grams. Solid products may be specified for it size and shape as desired by the buyer.
Tricalcium Phosphate or Calcium Phosphate Tribasic CAS Number 7758-87-4 or 1306-06-5 or 12167-74-7 or 62974-97-4
For Properties Specifications Uses of Tricalcium Phosphate or Calcium Phosphate Tribasic Click Properties, Specifications, Uses, Price, Process of Tricalcium Phosphate or Calcium Phosphate Tribasic Manufacturer.
For For SDS MSDS Sheet of Tricalcium Phosphate or Calcium Phosphate Tribasic Click SDS Safety Data Sheet MSDS Sheet of Tricalcium Phosphate or Calcium Phosphate Tribasic Manufacturer.
We supply as under:
Calcium Phosphate Monobasic or Monocalcium Phosphate
Calcium Phosphate Dibasic or Dicalcium Phosphate
Calcium Phosphate Tribasic or Tricalcium Phosphate (You are here).
The Properties, Specifications, Monograph and Uses of Tricalcium Phosphate or Calcium Phosphate Tribasic:
CAS Number 7758-87-4 or 1306-06-5 or 12167-74-7 or 62974-97-4, EINECS EC Number 231-840-8 *, HS Code: 28352620 or 28352690, Molecular Weight 310.18, Chemical Formula Ca5(OH)(PO4)3
Tricalcium phosphate is a calcium salt of phosphoric acid with the chemical formula Ca3(PO4)2. It is also known as tribasic calcium phosphate and bone phosphate of lime (BPL). It is a white solid of low solubility. As a nutritional supplement, tricalcium phosphate is comparable to other calcium supplements. Tricalcium phosphate has also found a proven place in industrial and agricultural applications. Tricalcium phosphate is used in powdered spices as an anticaking agent, e.g. to prevent table salt from caking. The calcium phosphates have been assigned European food additive number E341. It is also found in baby powder and toothpaste. It is also used as a nutritional supplement.
Tribasic Calcium Phosphate USP NF Grade Specifications:
Ca5(OH)(PO4)3 --- 502.31
Calcium hydroxide phosphate CAS 12167-74-7
DEFINITION
Tribasic Calcium Phosphate consists of a variable mixture of calcium phosphates with the approximate composition (10CaO3P2O5-H2O). It contains NLT 34.0% and NMT 40.0% of calcium (Ca).
IDENTIFICATION
A.
Sample solution: Dissolve 100 mg in 5 mL of diluted nitric acid.
Analysis: Warm the Sample solution and add 2 mL ammonium molybdate.
Acceptance criteria: A yellow precipitate is formed.
B.
Analysis: Dissolve the Sample by warming in 10 mL of 2 N hydrochloric acid. Add 2.5 mL of ammonia dropwise, with shaking, and then add 5 mL of ammonium oxalate.
Acceptance criteria: A white precipitate is formed.
ASSAY
Procedure
Sample: 150 mg of Tribasic Calcium Phosphate
Titrimetric system
Mode: Direct titration
Titrant: 0.05 M edetate disodium
Endpoint detection: Visual
Analysis: Dissolve the Sample, with the aid of gentle heat if necessary, in a mixture of hydrochloric acid and water (5:3) contained in a 250-mL beaker equipped with a magnetic stirrer, and cautiously add 125 mL of water. With constant stirring, add in the following order: 0.5 mL of triethanolamine, 300 mg of hydroxy naphthol blue, and from the titration burette, about 23 mL of Titrant. Add sodium hydroxide solution (45 in 100) until the initial red color changes to clear blue. Continue to add it dropwise until the color changes to violet and add an additional 0.5 mL. The pH is 12.3 to 12.5. Continue the titration dropwise with Titrant to the appearance of a clear blue endpoint that persists for NLT 60 s.
Calculate the percentage of calcium (Ca) in the portion of the Sample taken:
Result = [(V S x M x F)/W] x 100
V S = Titrant volume consumed by the Sample (mL)
M = actual molarity of the Titrant (mmol/mL)
F = equivalency factor, 40.08 mg/mmol
W = Sample weight (mg)
Acceptance criteria: 34.0% to 40.0%
Standard: 1.0 mL of 0.020 N hydrochloric acid
Sample: 0.500 g of Tribasic Calcium Phosphate
Analysis: Dissolve the Sample in 25 mL of 2 N nitric acid and add 1 mL of silver nitrate.
Acceptance criteria: NMT 0.14%
Chloride and Sulfate -Sulfate:
Standard: 1.0 mL of 0.020 N sulfuric acid
Sample: 0.500 g of Tribasic Calcium Phosphate
Analysis: Dissolve the Sample in the smallest possible amount of 3 N hydrochloric acid. Dilute with water to 100 mL, and filter, if necessary. To 25 mL of the filtrate add 1 mL of barium chloride.
Acceptance criteria: NMT 0.8%
Arsenic: To pass the test. --- 3 ppm
Barium:
Sample: 500 mg of Tribasic Calcium Phosphate
Analysis: Mix the Sample with 10 mL of water, heat, add hydrochloric acid, dropwise, until solution is affected, and then add 2 drops of the acid in excess. Filter, and add to the filtrate 1 mL of potassium sulfate.
Acceptance criteria: No turbidity appears within 15 min.
Carbonate:
Sample: 2 g of Tribasic Calcium Phosphate
Analysis: Mix the Sample with 20 mL of water, and add 3 N hydrochloric acid, dropwise, to effect solution.
Acceptance criteria: No effervescence is produced.
Acid-Insoluble Substances:
Analysis: If an insoluble residue remains in the test for Carbonate, boil the solution, filter, wash the residue well with hot water until the last washing is free from chloride, and ignite the residue to constant weight.
Acceptance criteria: NMT 0.2%; the weight of the residue is NMT 4 mg.
Dibasic Salt and Calcium Oxide: To pass the test.
Limit of Fluoride: To pass the test. --- NMT 75 ppm
Limit of Nitrate: To pass the test.
Water-Soluble Substances: To pass the test. --- NMT 0.5%.
Loss on Ignition:
Analysis: Ignite at 800C for 30 min.
Acceptance criteria: NMT 8.0%
Packaging and Storage: Preserve in well-closed containers.
Specifications of Tribasic Calcium Phosphate BP Ph Eur Grade
Calcium Phosphate BP
CAS 7758-23-8
DEFINITION
Calcium phosphate consists of a mixture of calcium phosphates. It contains not less than 35.0 per cent and not more than the equivalent of 40.0 per cent of Ca (Ar 40.08).
CHARACTERS
A white or almost white powder, practically insoluble in water. It dissolves in dilute hydrochloric acid and in dilute nitric acid.
IDENTIFICATION
A. Dissolve 0.1 g in 5 ml of a 25 per cent V/V solution of nitric acid R. The solution gives reaction (b) of phosphates (2.3.1).
B. It gives reaction (b) of calcium (2.3.1). Filter before adding potassium ferrocyanide solution R.
C. It complies with the limits of the assay.
TESTS
Solution S
Dissolve 2.50 g in 20 ml of dilute hydrochloric acid. If the solution is not clear, filter it. Add dilute ammonia drop-wise until a precipitate is formed. Dissolve the precipitate by adding dilute hydrochloric acid and dilute to 50 ml with distilled water.
Chlorides
Dissolve 0.22 g in a mixture of 1 ml of nitric acid and 10 ml of water and dilute to 100 ml with water. 15 ml of the solution complies with the limit test for chlorides (0.15 per cent).
Fluorides
Not more than 75 ppm of F, determined potentiometrically (2.2.36, Method I) using a fluoride-selective indicator electrode and a silver-silver chloride reference electrode.
Sulphates
Dilute 1 ml of solution S to 25 ml with distilled water 15 ml of the solution complies with the limit test for sulphates (0.5 per cent).
Arsenic
5 ml of solution S complies with limit test A for arsenic (4 ppm).
Iron
Dilute 0.5 ml of solution S to 10 ml with water R. The solution complies with the limit test for iron (400 ppm).
Heavy metals
Dilute 13 ml of solution S to 20 ml with water. 12 ml of the solution complies with limit test A for heavy metals (30 ppm).
Acid-insoluble matter
Dissolve 5.0 g in a mixture of 10 ml of hydrochloric acid and 30 ml of water. Filter, wash the residue with water and dry to constant mass at 100C to 105C. The residue weighs not more than 10 mg (0.2 per cent).
Loss on ignition
Not more than 8.0 per cent, determined on 1.000 g by ignition at 800C for 30 min.
Calcium Phosphate, Tribasic FCC Food Grade
Tricalcium Phosphate; Precipitated Calcium Phosphate
Calcium Hydroxyapatite
Ca3(PO4)2 Formula wt 310.18
Ca5OH(PO4)3 Formula wt 502.31
Ca10(OH)2(PO4)6 Formula wt 1004.61
INS: 341(iii) CAS: 7758-87-4
CAS: 1306-06-5
CAS: 62974-97-4
DESCRIPTION
Calcium Phosphate, Tribasic, occurs as a white powder that is stable in air. It consists of a variable mixture of calcium phosphates. It is insoluble in alcohol and almost insoluble in water, but it dissolves readily in dilute hydrochloric and nitric acids.
Function: Ant caking agent; buffer; nutrient; clouding agent.
REQUIREMENTS
Identification
A. Add ammonium molybdate TS to a warm solution of sample in a slight excess of nitric acid. A yellow precipitate forms.
B. Dissolve about 100 mg of sample by warming it with 5 mL of 2.7 N hydrochloric acid and 5 mL of water; while shaking, add 1 mL of 6 N ammonium hydroxide, drop-wise and then add 5 mL of ammonium oxalate TS. A white precipitate forms.
Assay: Not less than 34.0% and not more than 40.0% of calcium (Ca).
Arsenic: Not more than 3 mg/kg.
Fluoride: Not more than 0.0075%.
Lead: Not more than 2 mg/kg.
Loss on Ignition: Not more than 10.0%.
The MSDS-SDS Hazard Statement of Tricalcium Phosphate or Calcium Phosphate Tribasic:
Calcium Phosphate Tribasic SDS Safety Data Sheet
Tricalcium Phosphate MSDS, Material Safety Data Sheet 01-Jul-21
Product Name & Other Names1. Product Identification
Product Name & Other Names: Calcium Phosphate Tribasic or Tricalcium phosphate; Calcium hydroxy apatite; hydroxyapatite, Precipitated Calcium Phosphate.
CAS No.: 12167-74-7 or 7758-87-4 or 1306-06-5
EINECS EC-No. : 235-330-6 or 231-840-8
Chemical Formula: Ca5(OH)(PO4)3 and also Ca3(PO4)2-xH2O
Molecular Weight: 310.18, for Ca5(OH)(PO4)3
Recommended uses and uses advised against (if any): Industrial Manufacturing.
SUPPLIER: As per letterhead.
2. Hazards Identification
GHS, Globally Harmonized System Classification in accordance with 29 CFR 1910
Classification according to Regulation (EC) No 1272/2008
Not a hazardous substance or mixture according to Regulation (EC) No. 1272/2008.
This substance is not classified as dangerous according to Directive 67/548/EEC.
Labeling according to GHS USA & Regulation (EC) No 1272/2008
| GHS Label Elements None |
Signal Words: None
Precautionary statements:
P261: Avoid breathing dust/fume/gas/mist/vapors/spray.
P262: Do not get in eyes, on skin, or on clothing.
P281: Use personal protective equipment as required.
P302+P352 - IF ON SKIN: Wash with plenty of soap and water.
P304 + P340 - IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338 - IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+313: If eye irritation persists get medical advice/attention.
3. Composition/Information on Ingredients
Product Name & Other Names: Calcium Phosphate Tribasic or Tricalcium Phosphate
CAS No.: 12167-74-7 or 7758-87-4 or 1306-06-5
EINECS EC-No. : 235-330-6 or 231-840-8
4. First Aid Measures
Always seek medical attention after first aid measures are provided.
Inhalation: If inhaled, remove to fresh air. If breathing is difficult, give oxygen. Get medical attention.
Ingestion: Induce vomiting immediately as directed by medical personnel. Never give anything by mouth to an unconscious person.
Skin Contact: Immediately flush skin with plenty of water for at least 15 minutes. Remove contaminated clothing and shoes and wash before reuse. Get medical attention if irritation develops.
Eye Contact: Immediately flush eyes with plenty of water for at least 15 minutes, lifting lower and upper eyelids occasionally. Get medical attention immediately.
5. Fire Fighting Measures
Fire: Not considered to be a fire hazard.
Explosion: Not considered to be an explosion hazard.
Fire Extinguishing Media: Use any means suitable for extinguishing surrounding fire.
Extinguishing Media Not recommended: None specified.
Special Information: In the event of a fire, wear full protective clothing and NIOSH-approved self-contained breathing apparatus with full face piece operated in the pressure demand or other positive pressure mode. At high temperatures under fire conditions, it may produce toxic or irritating fumes. Fire-extinguishing work is done from the windward and the suitable fire-extinguishing method according to the surrounding situation is used. Uninvolved persons should evacuate to a safe place.
6. Accidental Release Measures
Personal precautions, protective equipment, and emergency procedures: Avoid breathing dust/fumes/gas/mist/vapors/spray. Use individual protective equipment (waterproof boots, suitable protective clothing, safety glasses, etc.). Restrict unprotected personnel from the area. Prevent any contact with hot surfaces. Do not approach facing the wind. Do not touch the spilled material.
Environmental precautions: Do not let the product enter drains, soil, or water sources.
Methods and materials used for containment Cleanup procedures and Storage: Do not inhale dust, vapors, mist, or gas. Avoid dust formation. Contain spilled material. Cover with an inert, non-combustible absorbent material, (e.g. sand, earth, diatomaceous earth, vermiculite). Use a shovel to put the material into a convenient waste disposal container. Finish cleaning by spreading water on the contaminated surface and allow to evacuate as per law.
7. Handling and Storage
Precautions for safe handling: Apply according to good manufacturing and industrial hygiene practices. Ensure proper ventilation. In case of insufficient ventilation, wear suitable respiratory equipment. Wash thoroughly after handling. Do not drink, eat, or smoke while handling. Avoid contact with skin, eyes, and clothing. Minimize dust generation. Avoid breathing dust/fumes/gas/mist/vapors/spray. Avoid contact with eyes, skin, and clothing. Keep container tightly closed. Avoid ingestion and inhalation. Use individual protective equipment (waterproof boots, suitable protective clothing, safety glasses, etc.). Prevent any contact with hot surfaces.
Conditions for safe storage, including any incompatibilities: Store in cool, dry, and ventilated area away from heat sources and protected from sunlight in tightly closed original container. Keep air contact to a minimum. Store protected from heat, sparks and ignition sources and incompatible materials. Avoid contact with skin and eyes. Avoid inhalation of dust/mist/vapor. Do not store with incompatible materials like strong oxidizing agents.
8. Exposure Controls/Personal Protection
Exposure Limits: This product does not contain any hazardous materials with occupational exposure limits established by the region-specific regulatory bodies.
Ventilation System: A system of local and/or general exhaust is recommended to keep employee exposures as low as possible. Local exhaust ventilation is generally preferred because it can control the emissions of the contaminant at its source, preventing dispersion of it into the general work area.
Personal Respirators (NIOSH Approved): For conditions of use where exposure to dust or mist is apparent and engineering controls are not feasible, a particulate respirator may be worn. For emergencies or instances where the exposure levels are not known, use a full-face positive-pressure, air-supplied respirator.
Skin Protection: Wear protective gloves and clean body-covering clothing.
Eye Protection: Use chemical safety goggles and/or full face shield where dusting or splashing of solutions is possible. Maintain eye wash fountain and quick-drench facilities in work area.
Other Control Measures: Maintain good housekeeping in work area. Dust deposits on floors and other surfaces may pick up moisture and cause the surfaces to become slippery and present safety hazards. Handle in accordance with good industrial hygiene and safety practice. Wash hands after handling.
9. Physical and Chemical Properties
Appearance: Fine, white powder.
Odor: Odorless.
Odor threshold: Not available.
pH: Not available.
Relative density: around 3.14
Melting Point: 1670C (3038F).
Initial boiling point and boiling range: Not available.
Flash point: Not available.
Auto-ignition temperature: Not available.
Decomposition temperature: Not available.
Upper/lower flammability or explosive limits: Not available.
Vapor pressure: Not available.
Vapor density: Not available.
Evaporation rate: Not available.
Flammability (solid, gas): Not available.
Partition coefficient: n-octanol/water: Not available.
Solubility: Practically insoluble in water.
Viscosity: Not available.
Chemical Formula: Ca5(OH)(PO4)3 and also Ca3(PO4)2-xH2O
Molecular Weight: 310.18, for Ca5(OH)(PO4)3
10. Stability and Reactivity
Stability: Stable under ordinary conditions of use and storage.
Hazardous Decomposition Products: No information found.
Hazardous Polymerization: Will not occur.
Incompatibilities: Strong oxidizing agents.
Conditions to Avoid: Excessive dust generation.
11. Toxicological Information
Toxicity to Animals: Not available.Carcinogenicity: No component of this product present at levels greater than or equal to 0.1% is identified as possible or confirmed human carcinogen by IARC, ACGIH, OSHA and NTP.
Mutagenic Effects: Not available.
Teratogenic Effects: Not available.
Developmental Toxicity: Not available.
Reproductive Effects: No information available.
12. Ecological Information
Toxicity to fish: No information available.
Persistence and Degradability: No information available.
Mobility: No information available.
Bioaccumulation/ Accumulation: No information available.
Results of PBT and vPvB assessment: No data available for assessment.
13. Disposal Considerations
Whatever cannot be saved for recovery or recycling should be managed in an appropriate and approved waste disposal facility. Processing use or contamination of this product may change the waste management options. State and local disposal regulations may differ from federal disposal regulations. Dispose of container and unused Tribasic Calcium Phosphate in accordance with federal, state, and local requirements.
14. Transport Information
Land Transport DOT USA, TDG Canada & ADR/RID Europe: Not dangerous goods.
Sea Transport IMDG/IMO: Not dangerous goods.
Air Transport IATA/ICAO: Not dangerous goods.
15. Regulatory Information
USA:
California Proposition 65: Not listed.
SARA 311/312: See section 2.
Section 16 - Additional Information
DISCLAIMER: The information and recommendations set forth herein are presented in good faith and believed correct as of the date hereof. It is compiled from various sources, and it is not necessarily all inclusive nor fully adequate in every circumstance. In addition, these suggestions should not be confused with nor followed in violation of applicable laws, regulations, rules, or insurance requirements applicable. This SDS MSDS sheet is intended only as a guide to the appropriate precautionary handling of the material by a professionally trained person using this product. Individuals receiving the information must exercise their independent judgment in determining its appropriateness for a particular purpose. This shall not constitute a guarantee for any specific product features and shall not establish a legally valid contractual relationship. In no case shall our company be liable to loss or damages by the product user.
Tricalcium Phosphate or Calcium Phosphate Tribasic Manufacturers, Suppliers, Exporters, Wholesalers:
King of Chemicals manufacturers
Plot No. 2900/46&47 + 2900/163to167, GIDC, Ankleshwar, Dist. Bharuch, India
India, USA, UAE
TEL: (Office) 91-22-23774610, 91-22-23723564
e-mail: info@kingofchemicals.com
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Hydrated Manganese Glycerophosphate |
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