Specifications, Uses, SDS of Chlorocresol Manufacturers

	King of Chemicals Manufacturers
Specifications, Properties, Uses, SDS of Chlorocresol USP NF BP Ph Eur Grade Manufacturer Supplier Exporter Wholesale & Small Packs, CAS Number 59-50-7.
King of Chemicals has several associated companies having accreditations like cGMP, GLP - FDA Approved Good Manufacturing Practice and Good Laboratory Practice of WHO standard, ISO-9001, ISO-14001, ISO/IEC 17025, ISO ISO-45000, HACCP, FSSC 220000, FSSAI, "REACH" Registered, Kosher & Halal Certified. e-CTD and DMF support can be made available if needed. We offer USP NF BP Ph Eur EP IP JP Analytical Reagent FCC Food Grade Chemicals & Nutraceuticals.

Muby Chem Pvt. Ltd. is a several decades old group of companies, engaged in manufacturing, supplying, distributing, wholesale supplies of Chlorocresol for actual users, including retail or small pack supplies for research and development work.

We supply fine and speciality chemicals, pharmaceutical excipients, mineral fortifiers in chemically pure, analytical reagent grade, IP BP USP Ph Eur EP JP and other pharmaceutical grade monograph including FCC Food grade chemicals and Nutraceuticals at best prices. We and/or our associated units have all the facilities to supply as per cGMP standard observing good manufacturing practice and good laboratory practice. We can assure low microbial count and also offer a test certificate for the same. We maintain warehouses across USA, India, and UAE. Our group exports to USA, Canada, Mexico, Argentina, Brazil, Chile, Korea, Malaysia, Thailand, Indonesia, Europe, and several other parts of the world. We supply in wholesale container loads to small pack of few grams. Solid products may be specified for it size and shape as desired by the buyer.

CAS Number: 59-50-7, EINECS EC Number: 200-431-6, Molecular Formula: C7H7ClO or ClC6H3(CH3)OH, Molecular Weight: 142.58, HS Code 29071290 or 38089990

p-Chlorocresol is the organic compound with the formula ClC6H4OH. It is a monochlorinated m-cresol. It is a white or colorless solid that is only slightly soluble in water. As a solution in alcohol and in combination with other phenols, it is used as an antiseptic and preservative. It is used as a preservative in paints and inks. It is also a veterinary medicine. It is also used in various pharmaceutical products to increase shelf life.

Chlorocresol USP NF Grade Specifications:
C7H7ClO --- 142.58
Phenol, 4-chloro-3-methyl-;
4-Chloro-m-cresol CAS 59-50-7]
DEFINITION
Chlorocresol contains NLT 99.0% and NMT 101.0% of C7H7ClO (4-chloro-3-methylphenol).
IDENTIFICATION
A.
Sample solution: Dissolve 40 mg of Chlorocresol in 10 mL of water.
Analysis: Add 1 drop of ferric chloride TS to the ;Sample solution.
Acceptance criteria: A blue color develops.
B.
Sample: 50 mg
Analysis: Transfer the Sample to a crucible, add 500 mg of anhydrous sodium carbonate, and mix. Heat the mixture until fused. Cool, add 5 mL of water, and boil. Acidify with 1 mL of nitric acid, filter, and add 1 mL of silver nitrate TS to the filtrate.
Acceptance criteria: A white precipitate is formed.
ASSAY
Procedure
Sample: 70 mg
Titrimetric system
Mode: Residual titration
Titrant: 0.1 N sodium thiosulfate.
Endpoint detection: Visual.
Analysis: Transfer the Sample to an iodine flask, add 30 mL of glacial acetic acid, 25.0 mL of 0.1 N bromine, 10 mL of potassium bromide solution (150 mg/mL), and 10 mL of hydrochloric acid.
Immediately insert the stopper, and allow to stand for 15 min, protected from light. Quickly add 10 mL of potassium iodide solution (100 mg/mL) and 100 mL of water, taking precautions against the escape of bromine vapor. Immediately insert the stopper and shake the mixture thoroughly. Remove the stopper and rinse it and the neck of the flask with a small quantity of water so that the washing flows into the flask. Add 1 mL of chloroform and shake the mixture thoroughly.
Titrate the liberated iodine with Titrant, adding 3 mL of starch TS as the endpoint is approached. Perform a blank determination. Each mL of 0.1 N bromine VS is equivalent to 3.565 mg of C7H7ClO (4-chloro-3-methylphenol).
Acceptance criteria: 99.0%–101.0%

Specifications of Chlorocresol BP Ph Eur Grade:
C7H7ClO --- 142.6 --- 59-50-7
Action and use: Antiseptic; antimicrobial preservative.

DEFINITION
4-Chloro-3-methylphenol.
Content: 98.0 per cent to 101.0 per cent.

CHARACTERS
Appearance: White or almost white, crystalline powder or compacted crystalline masses supplied as pellets or colourless or white crystals.
Solubility: Slightly soluble in water, very soluble in ethanol (96 per cent), freely soluble in fatty oils. It dissolves in solutions of alkali hydroxides.

IDENTIFICATION
A. Melting point: 64C to 67C.
B. To 0.1 g add 0.2 mL of benzoyl chloride and 0.5 mL of dilute sodium hydroxide solution. Shake vigorously until a white, crystalline precipitate is formed. Add 5 mL of water and filter. The precipitate, recrystallised from 5 mL of methanol and dried at 70C, melts at 85C to 88C.
C. To 5 mL of solution S (see Tests) add 0.1 mL of ferric chloride solution. A bluish colour is produced.

TESTS
Solution S: To 3.0 g, finely powdered, add 60 mL of carbon dioxide-free water, shake for 2 min and filter.
Appearance of solution: The solution is clear and not more intensely coloured than reference solution.
Dissolve 1.25 g in ethanol (96 per cent) and dilute to 25 mL with the same solvent.
Acidity: To 10 mL of solution S add 0.1 mL of methyl red solution. The solution is orange or red. Not more than 0.2 mL of 0.01 M sodium hydroxide is required to produce a pure yellow colour.
Related substances: To pass the test by gas chromatography.
Limits:
— unspecified impurities: for each impurity, maximum 0.10 per cent;
— total: maximum 1 per cent;
— disregard limit: the area of the principal peak in the chromatogram obtained with the reference solution (0.05 per cent).
Non-volatile matter: Maximum 0.1 per cent.
Evaporate 2.0 g to dryness on a water-bath and dry the residue at 100-105C. The residue weighs not more than 2 mg.

Chlorocresol or PCMC or 4-Chloro-3-methylphenol SDS Safety Data Sheet
MSDS, Material Safety Data Sheet 08-Jul-21

Product Name & Other Names: p-Chlorocresol or PCMC or 4-Chloro-3-methylphenol.
CAS No.: 59-50-7
EINECS EC Number: 200-431-6
Chemical Formula: C7H7ClO or ClC6H3(CH3)OH
Molecular Weight: 142.58
Relevant uses and uses advised against (if any): Industrial Manufacturing.
Suppliers: As per letterhead.

GHS, Globally Harmonized System Classification in accordance with 29 CFR 1910
Classification according to Regulation (EC) No 1272/2008
Acute toxicity, oral Category 4, H302
Acute toxicity, Dermal Category 4, H312
Skin sensitization, Sub-category 1B, H317
Serious eye damage Category 1, H318
Short-term (acute) aquatic hazard Category 1, H400

Hazard statements:
H302 + H312 Harmful if swallowed or in contact with skin.
H317 May cause an allergic skin reaction.
H318 Causes serious eye damage.
H400 Very toxic to aquatic life.

Precautionary statements:
P202: Do not handle until all safety precautions have been read and understood.
P260: Do not breathe dust/fume/gas/mist/vapors/spray.
P264: Wash … thoroughly after handling.
P270: Do not eat, drink, or smoke when using this product.
P271: Use only outdoors or in a well-ventilated area.
P273: Avoid release to the environment.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P284: Wear respiratory protection.
P301+310: IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P304+340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P308+313: IF exposed or concerned: Get medical advice/attention.
P391: Collect spillage.
P405: Store locked up.
P403+233: Store in a well-ventilated place. Keep container tightly closed.
P501: Dispose of contents/container in accordance with local/regional/national/international regulation.

Product Name & Other Names: p-Chlorocresol or PCMC or 4-Chloro-3-methylphenol.
CAS No.: 59-50-7
EINECS EC Number: 200-431-6

Ingestion: Never give anything by mouth to an unconscious person. Get medical attention.
Skin: Immediately flush skin with plenty of water for at least 15 minutes. Remove and wash contaminated clothing and shoes before reuse. Get medical attention if irritation develops.
Eyes: Immediately flush eyes with plenty of water for 15 minutes, occasionally lifting upper and lower eyelids. Hold eyelids apart during irrigation. Get medical attention.
Inhalation: Remove person to fresh air. If breathing is difficult, give oxygen. If not breathing administer artificial respiration. Get medical attention.

Flash Point: N/A
Fire/Explosion: Not considered to be a fire and explosion hazard.
Extinguishing Medium: Water spray, alcohol-resistant foam, dry chemical or carbon dioxide.
Extinguishing Media Not recommended: Avoid using solid water jet as it may scatter the fire.
Special hazards arising from the substance or mixture: Fumes may evolve along with carbon oxides and hydrogen chloride.
Fire Fighting Instructions: Use suitable protective equipment for surrounding fire.
Special Information: In the event of a fire, wear full protective clothing and NIOSH-approved self-contained breathing apparatus with full face piece operated in the pressure demand or other positive pressure mode. At high temperatures under fire conditions, it may produce toxic or irritating fumes. Fire-extinguishing work is done from the windward and the suitable fire-extinguishing method according to the surrounding situation is used. Uninvolved persons should evacuate to a safe place.

Personal precautions, protective equipment, and emergency procedures: Avoid breathing dust/fumes/gas/mist/vapors/spray. Ensure adequate ventilation. Do not touch or walk through this product. Use individual protective equipment (waterproof boots, suitable protective clothing, safety glasses, etc.). Restrict unprotected personnel from the area. Prevent any contact with hot surfaces. Do not approach facing the wind. Do not touch the spilled material.
Environmental precautions: Do not let the product enter drains, soil, or water sources.
Methods and materials used for containment cleanup procedures and Storage: Contain spilled material. Cover with an inert, non-combustible absorbent material, (e.g., sand, earth, diatomaceous earth, vermiculite). Vacuum or sweep-up and remove to an approved disposal container.

Harmful hazardous material. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Avoid exposure.
Precautions for safe handling: Apply according to good manufacturing and industrial hygiene practices. Ensure proper ventilation. Wash thoroughly after handling. Do not drink, eat, or smoke while handling. Avoid contact with skin, eyes, and clothing. Minimize dust generation. Avoid breathing dust/fumes/gas/mist/vapors/spray. Avoid prolonged or repeated exposure. Keep container tightly closed. Avoid ingestion and inhalation. Use individual protective equipment (waterproof boots, suitable protective clothing, safety glasses, etc.). Prevent any contact with hot surfaces.
Conditions for safe storage, including any incompatibilities: Store in cool, dry, and ventilated area away from heat sources and protected from sunlight in tightly closed original container. Keep air contact to a minimum. Do not leave the material container open. Store protected from heat, sparks and ignition sources and incompatible materials. Avoid contact with skin and eyes. Avoid inhalation of dust/mist/vapor. Do not store with incompatible materials like oxidizing agents.

Exposure Limits: Contains no components with established occupational exposure limits.
Engineering Controls: Use adequate exhaust ventilation to keep airborne concentrations below the allowable exposure limit.
Ventilation System: A system of local and/or general exhaust is recommended to keep employee exposures as low as possible. Local exhaust ventilation is generally preferred because it can control the emissions of the contaminant at its source, preventing dispersion of it into the general work area.
Personal Respirators (NIOSH Approved): For conditions of use where exposure to dust or mist is apparent and engineering controls are not feasible, a particulate respirator may be worn. For emergencies or instances where the exposure levels are not known, use a full-face positive-pressure, air-supplied respirator.
Skin Protection: Wear protective gloves and clean body-covering clothing.
Eye Protection: Use chemical safety goggles and/or full-face shield where dusting or splashing of solutions is possible. Maintain eye wash fountain and quick-drench facilities in work area.
Other Control Measures: Maintain good housekeeping in work area. Dust deposits on floors and other surfaces may pick up moisture and cause the surfaces to become slippery and present safety hazards. Handle in accordance with good industrial hygiene and safety practice. Wash hands after handling.

Appearance: White/pink solid.
Odor: Phenolic.
Odor threshold: Not available.
pH: Not available.
Relative density: 1.37 @ 20C.
Melting Point: 64C-67C literature.
Initial boiling point and boiling range: 235C literature.
Flash point: Not available.
Auto-ignition temperature: Not available.
Decomposition temperature: Not available.
Upper/lower flammability or explosive limits: Not available.
Vapor pressure: Not available.
Vapor density: Not available.
Evaporation rate: Not available.
Flammability (solid, gas): Not available.
Partition coefficient: n-octanol/water: Not available.
Solubility(ies): 3.8 g/l @20C in water.
Viscosity: Not available.
Chemical Formula: C7H7ClO or ClC6H3(CH3)OH
Molecular Weight: 142.58

Chemical Stability: Stable under normal temperatures and pressures.
Incompatibility (Materials to Avoid): Oxidizing agents, copper, and alloys.
Conditions to Avoid: Incompatible materials, excessive heat.
Hazardous Decomposition Products: Fumes may evolve along with carbon oxides and hydrogen chloride.
Hazardous Polymerization: Will not occur.

Toxicity to Animals:
LC50 Inhalation - Rat - 4 h – >287 mg/l
LD50 Oral - Rat - 1830 mg/kg
LD50 Dermal - Rat - female - 2.000 mg/kg
Carcinogenicity: No component of this product present at levels greater than or equal to 0.1% is identified as probable, possible, or confirmed human carcinogen by IARC, NTP ACGIH or OSHA.
Mutagenic Effects: No information found.
Reproductive Effects: No information found.
Developmental Toxicity: No information found.

Ecotoxicity: Very toxic to aquatic organisms.
Toxicity to fish: semi-static test LC50 - Oncorhynchus mykiss (rainbow trout) - 0,92 mg/l - 96,0 h.
Toxicity to daphnia and other aquatic invertebrates: static test EC50 - Daphnia magna (Water flea) - 2,29 mg/l - 48 h.
Persistence and Degradability: Degradable.
Mobility: Likely to be mobile.
Bioaccumulation/ Accumulation: No information available.
Results of PBT and vPvB assessment: No data available for assessment.

Dispose of in accordance with all applicable local, state, and federal regulations at an approved waste disposal facility.

Land Transport DOT USA, TDG Canada & ADR/RID Europe:
UN-No UN 3077
Proper Shipping Name: Environmentally hazardous substance, solid, n.o.s. (Chlorocresol)
Hazard Class 9, Packing Group III
Sea Transport IMDG/IMO
UN-No UN 3077
Proper Shipping Name: Environmentally hazardous substance, solid, n.o.s. (Chlorocresol)
Hazard Class 9, Packing Group III
Air Transport IATA:
UN-No UN 3077
Proper Shipping Name: Environmentally hazardous substance, solid, n.o.s. (Chlorocresol)
Hazard Class 9, Packing Group III.

USA:
SARA 311/312: Acute Health Hazard; Chronic Health Hazard, as per section 2.
California Prop.65: This product contains no chemical known to the State of California to cause birth defects or other reproductive harm.

Chlorocresol Manufacturers, Suppliers, Exporters, Wholesalers:

Plot No. 2900/46&47 + 2900/163to167, GIDC, Ankleshwar, Dist. Bharuch, India
India, USA, UAE
TEL: (Office) 91-22-23774610, 91-22-23723564

If I give you “My Word” Nobody can undo it.
If I sign an “Agreement” my Lawyer will undo it

Our products are for industrial and laboratory use only. The user must test the material before use. We are not dispensing chemists or druggist and do not offer over the counter type (OTC) products for medical use by individuals.

Specifications, Properties, Uses, SDS of Chlorocresol USP NF BP Ph Eur Grade Manufacturer Supplier Exporter Wholesale & Small Packs, CAS Number 59-50-7.

Chlorocresol Manufacturers, Suppliers, Exporters, Wholesalers: