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Specifications, Properties, Uses, SDS of Sodium Picosulfate or Sodium Picosulphate USP BP Ph Eur Grade Manufacturer Supplier Exporter Wholesale & Small Packs, CAS Number 10040-45-6.

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Muby Chem Pvt. Ltd. is a several decades old group of companies, engaged in manufacturing, supplying, distributing, wholesale supplies of Sodium Picosulfate or Sodium Picosulphate for actual users, including retail or small pack supplies for research and development work.

We supply fine and speciality chemicals, pharmaceutical excipients, mineral fortifiers in chemically pure, analytical reagent grade, IP BP USP Ph Eur EP JP and other pharmaceutical grade monograph including FCC Food grade chemicals and Nutraceuticals at best prices. We and/or our associated units have all the facilities to supply as per cGMP standard observing good manufacturing practice and good laboratory practice. We can assure low microbial count and also offer a test certificate for the same. We maintain warehouses across USA, India, and UAE. Our group exports to USA, Canada, Mexico, Argentina, Brazil, Chile, Korea, Malaysia, Thailand, Indonesia, Europe, and several other parts of the world. We supply in wholesale container loads to small pack of few grams. Solid products may be specified for it size and shape as desired by the buyer.

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Sodium Picosulfate Picosulphate Manufacturer Supplier Exporter
Sodium Picosulfate or Sodium Picosulphate CAS Number 10040-45-6

For Properties Specifications Uses of Sodium Picosulfate or Sodium Picosulphate Click Properties, Specifications, Uses, Price, Process of Sodium Picosulfate or Sodium Picosulphate Manufacturer.

For For SDS MSDS Sheet of Sodium Picosulfate or Sodium Picosulphate Click SDS Safety Data Sheet MSDS Sheet of Sodium Picosulfate or Sodium Picosulphate Manufacturer.

The Properties, Specifications, Monograph and Uses of Sodium Picosulfate or Sodium Picosulphate:

CAS Number: 10040-45-6, EINECS EC Number: 233-120-9, Molecular Formula: C18H13NNa2O8S2, Molecular Weight: 499.42, HS Code 29420090 or 29122100 or 29333990 or 30049099

Sodium picosulfate or sodium picosulphate is a contact stimulant laxative used as a treatment for constipation or to prepare the large bowel before colonoscopy or surgery. Sodium Picosulfate is a laxative. It works by increasing the movement of the intestines, thereby facilitating the passage of stool.

Sodium Picosulfate USP Grade Specifications:
C18H13NNa2O8S2-H2O --- 499.42
C18H13NNa2O8S2 --- 481.41
4,4′-(2-Pyridylmethylene)diphenyl bis(hydrogen sulfate) disodium salt, monohydrate;
Disodium 4,4′-(pyridin-2-ylmethanediyl)dibenzenesulfate
4,4′-(Pyridin-2-ylmethylene)bisphenyl bis(sodium sulfate), monohydrate CAS 10040-45-6.

DEFINITION
Sodium Picosulfate contains NLT 98.5% and NMT 100.5% of sodium picosulfate (C18H13NNa2O8S2), calculated on the anhydrous basis.

IDENTIFICATION
A. Infrared Absorption
B. Identification Tests-General, Sodium: Meets the requirements for the pyroantimonate precipitate test.

ASSAY
Procedure
Sample solution: Dissolve 400 mg of Sodium Picosulfate in 80 mL of methanol.
Analysis: Titrate with 0.1 N perchloric acid determining the endpoint potentiometrically. Perform a blank determination and make any necessary correction. Each mL of 0.1 N perchloric acid is equivalent to 48.14 mg of sodium picosulfate (C18H13NNa2O8S2).
Acceptance criteria: 98.5% to 100.5% on the anhydrous basis

Chloride and Sulfate, Chloride: A 1.0-g portion shows no more chloride than corresponds to 0.30 mL of 0.020 N hydrochloric acid: NMT 0.02%.
Chloride and Sulfate, Sulfate: A 500-mg portion shows no more sulfate than corresponds to 0.20 mL of 0.020 N sulfuric acid: NMT 0.04%.
Organic Impurities: To pass the test by Chromatography.
Color of Solution: To pass the test.
Acidity and Alkalinity:
Analysis: To 10 mL of the portion of Sample solution retained from the test for Color of Solution add a drop of phenolphthalein.
Acceptance criteria: The solution is colorless. NMT 0.25 mL of 0.01 N sodium hydroxide is required to change the color of the indicator to pink.
Water Determination: 3.0% to 5.0%
Packaging and Storage: Preserve in tight, light-resistant containers. Store at room temperature.

Specifications of Sodium Picosulfate BP Ph Eur Grade
C18H13NNa2O8S2,H2O --- 499.4 --- CAS 10040-45-6
Action and use: Stimulant laxative.

DEFINITION
Sodium picosulfate contains not less than 98.5 per cent and not more than the equivalent of 100.5 per cent of 4,4¢-(pyridin-2-ylmethylene)bisphenyl bis(sodium sulphate), calculated with reference to the anhydrous substance.

CHARACTERS
A white or almost white, crystalline powder, freely soluble in water, slightly soluble in alcohol.

IDENTIFICATION
First identificationiA, E.
Second identificationiB, C, D, E.
A. Examine by infrared absorption spectrophotometry (2.2.24), comparing with the spectrum obtained with sodium picosulfate CRS. Examine the substances prepared as discs.
B. Examine the chromatograms obtained in the test for related substances in ultraviolet light at 254 nm. The principal spot in the chromatogram obtained with test solution (b) is similar in position and size to the principal spot in the chromatogram obtained with reference solution (a).
C. To 5 ml of solution S (see Tests) add 1 ml of dilute hydrochloric acid and heat to boiling. Add 1 ml of barium chloride solution. A white precipitate is formed.
D. To about 10 mg add 3 ml of sulphuric acid and 0.1 ml of potassium dichromate solution
R1. A violet colour develops.
E. The solution S gives reaction (a) of sodium (2.3.1).

TESTS
Solution S: Dissolve 2.5 g in distilled water R and dilute to 50 ml with the same solvent.
Appearance of solution: Solution S is clear and not more intensely coloured than reference.
Acidity or alkalinity: To 10 ml of solution S add 0.05 ml of phph solution. The solution is colourless. Not more than 0.25 ml of 0.01 M sodium hydroxide is required to change the colour of the indicator to pink.
Related substances: To pass the test.
Chlorides: Dilute 5 ml of solution S to 15 ml with water. The solution complies with the limit test for chlorides (200 ppm).
Sulphates: Dilute 7.5 ml of solution S to 15 ml with distilled water R. The solution complies with the limit test for sulphates (400 ppm).
Heavy metals: 12 ml of solution S complies with limit test A for heavy metals (20 ppm).
Water: 3.0 per cent to 5.0 per cent, determined on 0.500 g by the semi-micro determination of water.


The MSDS-SDS Hazard Statement of Sodium Picosulfate or Sodium Picosulphate:

Sodium Picosulfate or Sodium Picosulphate SDS, Safety Data Sheet
MSDS, Material Safety Data Sheet
25-Jul-21

1. PRODUCT DESCRIPTION

Product Name & Other Names: Sodium Picosulfate or Sodium Picosulphate.
CAS Number: 10040-45-6
EINECS EC Number: 233-120-9
Molecular Formula: C18H13NNa2O8S2
Molecular Weight: 499.42
Relevant uses and uses advised against (if any): Industrial Manufacturing.
Suppliers: As per letterhead.

2. HAZARD IDENTIFICATION

GHS, Globally Harmonized System Classification in accordance with 29 CFR 1910
Classification according to Regulation (EC) No 1272/2008

Not a hazardous substance or mixture according to Regulation (EC) No. 1272/2008.
This substance is not classified as dangerous according to Directive 67/548/EEC.

Labeling according GHS & Regulation (EC) No 1272/2008

GHS Label Elements
None

Signal Words: None

Precautionary statements:
P261: Avoid breathing dust/fume/gas/mist/vapors/spray.
P262: Do not get in eyes, on skin, or on clothing.
P281: Use personal protective equipment as required.
P302+P352 - IF ON SKIN: Wash with plenty of soap and water.
P304 + P340 - IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338 - IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+313: If eye irritation persists get medical advice/attention.

3. COMPOSITION/INFORMATION ON INGREDIENTS

Product Name & Other Names: Sodium Picosulfate or Sodium Picosulphate.
CAS Number: 10040-45-6
EINECS EC Number: 233-120-9

4. FIRST AID MEASURES

Always get medical attention after the first aid is over.

Emergency and First Aid Procedures:
Eyes - Flush with water for at least 15 minutes, raising and lowering eyelids occasionally. Get medical attention if irritation persists.
Skin - Thoroughly wash exposed area for at least 15 minutes. Remove contaminated clothing. Launder contaminated clothing before reuse. Get medical attention if irritation persists.
Ingestion - If swallowed, if conscious, give plenty of water. Immediately call a physician.
Inhalation - Remove to fresh air. Give oxygen if breathing is difficult; give artificial respiration if breathing has stopped. Keep person warm, quiet, and get medical attention.

5. FIREFIGHTING PROCEDURES

Extinguisher Media: Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide..
Special Fire fighting Procedures: Firefighters should wear full protective equipment and NIOSH approved self-contained breathing apparatus.
Unusual Fire and Explosion Hazards: Heated to decomposition, however, toxic oxides of sulfur may be evolved.
Extinguishing Media Not recommended: Avoid using solid water jet as it may scatter the fire.
Special Information: In the event of a fire, wear full protective clothing and NIOSH-approved self-contained breathing apparatus with full face piece operated in the pressure demand or other positive pressure mode. At high temperatures under fire conditions, it may produce toxic or irritating fumes. Fire-extinguishing work is done from the windward and the suitable fire-extinguishing method according to the surrounding situation is used. Uninvolved persons should evacuate to a safe place.

6. SPILL OR LEAK PROCEDURES

Personal precautions, protective equipment and emergency procedures: Ventilate area of spill. Avoid creating dust. Avoid breathing dust/fumes/gas/mist/vapors/spray. Use individual protective equipment (waterproof boots, suitable protective clothing, safety glasses, etc.). Restrict unprotected personnel from the area. Prevent any contact with hot surfaces. Do not approach facing the wind. Do not touch the spilled material.
Environmental precautions: Do not let the product enter drains, soil or water sources.
Methods and materials used for containment Cleanup procedures and Storage: Contain spilled material. Cover with an inert, non-combustible absorbent material, (e.g. sand, earth, diatomaceous earth, vermiculite). Vacuum or sweep-up and remove to an approved disposal container.

7. SPECIAL PRECAUTIONS

Precautions for safe handling: Apply according to good manufacturing and industrial hygiene practices. Ensure proper ventilation. Wash thoroughly after handling. Do not drink, eat or smoke while handling. Provide appropriate exhaust ventilation at places where dust is formed. Avoid contact with skin, eyes and clothing. Minimize dust generation. Avoid breathing dust/fumes/gas/mist/vapors/spray. Avoid contact with eyes, skin, and clothing. Keep container tightly closed. Avoid ingestion and inhalation. Use individual protective equipment (waterproof boots, suitable protective clothing, safety glasses, etc.). Prevent any contact with hot surfaces.
Conditions for safe storage, including any incompatibilities: Store in cool, dry and ventilated area away from heat sources and protected from sunlight in tightly closed original container. Keep air contact to a minimum. Do not leave the material container open. Store protected from heat, sparks and ignition sources and incompatible materials. Avoid contact with skin and eyes. Avoid inhalation of dust/mist/vapor. Do not store with incompatible materials like oxidizing agents.

8. SPECIAL PROTECTION INFORMATION

Exposure Limits: This product does not contain any hazardous materials with occupational exposure limits established by the region-specific regulatory bodies. There is a blanket recommendation of 10 mg/m3 for inspirable dusts or mists when limits have not otherwise been established.
Respiratory Protection (Specify Type): None needed under normal conditions of use with adequate ventilation. NIOSH approved equipment should be worn if PELs are exceeded.
Ventilation System: A system of local and/or general exhaust is recommended to keep employee exposures as low as possible. Local exhaust ventilation is generally preferred because it can control the emissions of the contaminant at its source, preventing dispersion of it into the general work area.
Personal Respirators (NIOSH Approved): For conditions of use where exposure to dust or mist is apparent and engineering controls are not feasible, a particulate respirator may be worn. For emergencies or instances where the exposure levels are not known, use a full-face positive-pressure, air-supplied respirator.
Skin Protection: Wear protective gloves and clean body-covering clothing.
Eye Protection: Use chemical safety goggles and/or full face shield where dusting or splashing of solutions is possible. Maintain eye wash fountain and quick-drench facilities in work area.
Other Control Measures: Maintain good housekeeping in work area. Dust deposits on floors and other surfaces may pick up moisture and cause the surfaces to become slippery and present safety hazards. Handle in accordance with good industrial hygiene and safety practice. Wash hands after handling.

9. PHYSICAL DATA

Physical State: White crystalline solid.
Appearance and Odor: Sodium Picosulfate is white crystals or powder, no odor.
Odor: Not available.
Odor threshold: Not available.
pH: Not available.
Relative density: Not available.
Melting Point: 272-275C
Initial boiling point and boiling range: Not available.
Flash point: Not available.
Auto-ignition temperature: Not available.
Decomposition temperature: Not available.
Upper/lower flammability or explosive limits: Not available.
Vapor pressure: Not available.
Vapor density: Not available.
Evaporation rate: Not available.
Flammability (solid, gas): Not available.
Partition coefficient: n-octanol/water: Not available.
Solubility in Water: Soluble
Viscosity: Not available.
Molecular Formula: C18H13NNa2O8S2
Molecular Weight: 499.42

10. REACTIVITY DATA

Stability: Sodium Picosulfate is stable
Conditions to Avoid: Dust generation, Incompatibles
Incompatibility (Materials to Avoid): Strong Oxidizing Agents.
Hazardous Decomposition Products: Oxides of Nitrogen, Sulfur, Carbon, Sodium.
Hazardous Polymerization: Will not occur.

11. TOXICITY DATA

Toxicity Data: LD50 Oral - Mouse - 5989 mg/kg
Carcinogenicity: No component of this product present at levels greater than or equal to 0.1% is identified as possible or confirmed human carcinogen by IARC, ACGIH, OSHA and NTP.
Developmental Toxicity: Not available.
Reproductive Effects: No information available.

12. ECOLOGICAL DATA

Toxicity to fish, daphnia and other aquatic invertebrates: No data available.
Mobility: Likely to be mobile.
Bioaccumulation/ Accumulation: Unlikely.
Results of PBT and vPvB assessment: No data available for assessment.

13. DISPOSAL INFORMATION

Waste Disposal Methods: Dispose in accordance with all applicable regulations.

14. TRANSPORT INFORMATION

Land Transport DOT USA, TDG Canada & ADR/RID Europe: Not dangerous goods.
Sea Transport IMO/IMDG: Not dangerous goods.
Air Transport IATA/IMO: Not dangerous goods.

15. REGULATORY INFORMATION

USA Regulations:
California Proposition 65: Not listed.
SARA 311/312 Hazards: See section 2.

16. ADDITIONAL INFORMATION

DISCLAIMER: The information and recommendations set forth herein are presented in good faith and believed correct as of the date hereof. It is compiled from various sources, and it is not necessarily all inclusive nor fully adequate in every circumstance. In addition, these suggestions should not be confused with nor followed in violation of applicable laws, regulations, rules, or insurance requirements applicable. This SDS MSDS sheet is intended only as a guide to the appropriate precautionary handling of the material by a professionally trained person using this product. Individuals receiving the information must exercise their independent judgment in determining its appropriateness for a particular purpose. This shall not constitute a guarantee for any specific product features and shall not establish a legally valid contractual relationship. In no case shall our company be liable to loss or damages by the product user.

Muby Chem P Ltd

Sodium Picosulfate or Sodium Picosulphate Manufacturers, Suppliers, Exporters, Wholesalers:

King of Chemicals manufacturers

Muby Chem Private Limited
Plot No. 2900/46&47 + 2900/163to167, GIDC, Ankleshwar, Dist. Bharuch, India
India, USA, UAE
TEL: (Office) 91-22-23774610, 91-22-23723564

e-mail: info@kingofchemicals.com

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Our products are for industrial and laboratory use only. The user must test the material before use. We are not dispensing chemists or druggist and do not offer over the counter type (OTC) products for medical use by individuals.

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