Specifications, Uses, SDS of Sodium Stibogluconate Manufacturers

	King of Chemicals Manufacturers
Specifications, Properties, Uses, SDS of Sodium Stibogluconate BP Ph Eur Grade Manufacturer Supplier Exporter Wholesale & Small Packs, CAS Number 16037-91-5.
King of Chemicals has several associated companies having accreditations like cGMP, GLP - FDA Approved Good Manufacturing Practice and Good Laboratory Practice of WHO standard, ISO-9001, ISO-14001, ISO/IEC 17025, ISO ISO-45000, HACCP, FSSC 220000, FSSAI, "REACH" Registered, Kosher & Halal Certified. e-CTD and DMF support can be made available if needed. We offer USP NF BP Ph Eur EP IP JP Analytical Reagent FCC Food Grade Chemicals & Nutraceuticals.

Muby Chem Pvt. Ltd. is a several decades old group of companies, engaged in manufacturing, supplying, distributing, wholesale supplies of Sodium Stibogluconate for actual users, including retail or small pack supplies for research and development work.

We supply fine and speciality chemicals, pharmaceutical excipients, mineral fortifiers in chemically pure, analytical reagent grade, IP BP USP Ph Eur EP JP and other pharmaceutical grade monograph including FCC Food grade chemicals and Nutraceuticals at best prices. We and/or our associated units have all the facilities to supply as per cGMP standard observing good manufacturing practice and good laboratory practice. We can assure low microbial count and also offer a test certificate for the same. We maintain warehouses across USA, India, and UAE. Our group exports to USA, Canada, Mexico, Argentina, Brazil, Chile, Korea, Malaysia, Thailand, Indonesia, Europe, and several other parts of the world. We supply in wholesale container loads to small pack of few grams. Solid products may be specified for it size and shape as desired by the buyer.

The Properties, Specifications, Monograph and Uses of Sodium Stibogluconate:

CAS Number: 16037-91-5, Molecular Weight: 910.9, Chemical Formula: ‎C12H35Na3O26Sb2+, HS Code 30049026

Sodium stibogluconate is used in pharmaceutial Industries. Sodium stibogluconate is a medicine used to treat leishmaniasis. It belongs to the class known as the pentavalent antimonials. Sodium stibogluconate. It is on the World Health Organization's List of Essential Medicines. Although antimony itself is a cause of heavy metal poisoning, stibogluconate does not appear to accumulate in the body and is excreted by the kidneys. The mechanism of use of sodium stibogluconate is poorly understood.

Sodium Stibogluconate BP Ph Eur Grade Specifications:
CAS 16037-91-5
Action and use: Pentavalent antimony compound; antiprotozoal.

DEFINITION
Sodium Stibogluconate is mainly the disodium salt of µ-oxy-bis[gluconato(3-)-O2, O3,O4-hydroxoantimony]. It contains not less than 30.0% and not more than 34.0% of antimony(V), calculated with reference to the dried and methanol-free substance.

PRODUCTION
The method of manufacture is such as to ensure consistently controlled reaction stoichiometry in order to yield sodium stibogluconate that is satisfactory with regard to intrinsic toxicity.

CHARACTERISTICS
A colourless, mostly amorphous powder.
Very soluble in water; practically insoluble in ethanol (96%) and in ether.

IDENTIFICATION
A. A solution is dextrorotatory.
B. Pass hydrogen sulfide into a 5% w/v solution for several minutes. An orange precipitate is produced.
C. When heated, it chars without melting leaving a residue which yields the reactions characteristic of antimony compounds and the reactions characteristic of sodium salts.

TESTS
Stability and acidity of solution: Heat a solution containing the equivalent of 10% w/v of antimony(V) in an autoclave at 115.5° and at a pressure of 70 kPa for 30 minutes. The resulting solution is colourless or almost colourless and has a pH of 5.0 to 5.6.
Antimony(III): Dissolve 2 g in 30 mL of water, add 15 ;mL of hydrochloric acid and titrate with 0.00833M potassium bromate using methyl orange solution as indicator. Not more than 1.3 mL of 0.00833M potassium bromate is required.
Chloride: Dissolve 2.5 g in 50 mL of water and add 2 mL of 2M nitric acid and 75 mL of acetate buffer pH 5.0. Titrate with 0.1M silver nitrate determining the end point potentiometrically. Not more than 3.0 ;mL of 0.1M silver nitrate is required.
Methanol: Not more than 2.0% w/w when determined by the following method. Carry out the method for gas chromatography, using the following solutions. For solution (1) add 1 mL of a 1.0% v/v solution of methanol to 5 mL of a 0.2% v/v solution of absolute ethanol (internal standard). For solution (2) add 5 mL of water to 0.5 g of the substance being examined and mix with the aid of ultrasound until solution is complete. For solution (3) add 5 mL of a 0.2% v/v solution of the internal standard to 0.5 g of the substance being examined and mix with the aid of ultrasound until solution is complete.
The chromatographic procedure may be carried out using a glass column (1.5 m × 4 mm) packed with porous polymer beads (80 to 100 mesh) (Porapak Q and Chromosorb 101 are suitable) and maintained at 130C.
Calculate the percentage w/w of methanol taking 0.792 g as its weight per mL at 20C.
Loss on drying: When dried to constant weight at 130C at a pressure not exceeding 0.7 kPa, loses not more than 15.0% of its weight. Use 1 g.

Sodium Stibogluconate SDS, Safety Data Sheet
MSDS, Material Safety Data Sheet 26-Jul-21

Product Name & Other Names: Sodium Stibogluconate.
CAS No.: 16037-91-5
Relevant uses and uses advised against (if any): Industrial Manufacturing.
Suppliers: As per letterhead.

GHS, Globally Harmonized System Classification in accordance with 29 CFR 1910
Classification according to Regulation (EC) No 1272/2008
Acute toxicity, Oral Category 4, H302
Acute toxicity, inhalation Category 4, H332
Chronic aquatic toxicity Category 2, H411

Hazard statements:
H302: Harmful if swallowed.
H332: Harmful if inhaled.
H411: Toxic to aquatic life with long lasting effects.

Precautionary statements:
P261: Avoid breathing dust/ fume/ gas/ mist/ vapors/ spray.
P262: Do not get in eyes, on skin, or on clothing.
P264: Wash skin thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P271: Use only outdoors or in a well-ventilated area.
P273: Avoid release to the environment.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P330: Rinse mouth
P301+P312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell.
P304+340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P314: Get Medical advice/attention if you feel unwell.
P330: Rinse mouth.
P360: Rinse immediately contaminated clothing and skin with plenty of water before removing clothes.
P391: Collect spillage.
P501: Dispose of contents/ container to an approved waste disposal plant.

Inhalation: Remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical attention.
Ingestion: Never give anything by mouth to an unconscious person. Get medical attention.
Skin Contact: Wipe off excess material from skin then immediately flush skin with plenty of water for at least 15 minutes. Remove contaminated clothing and shoes. Get medical attention. Wash clothing before reuse. Thoroughly clean shoes before reuse.
Eye Contact: Immediately flush eyes with plenty of water for at least 15 minutes, lifting lower and upper eyelids occasionally. Get medical attention immediately.

Flammability of the Product: Non-flammable.
Products of Combustion: Carbon oxides, Sodium oxides, Antimony oxide.
Fire: Not considered to be a fire hazard.
Fire Extinguishing Media: Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide. Use means suitable for extinguishing surrounding fire.
Extinguishing Media Not recommended: Avoid using solid water jet as it may scatter the fire.
Special Information: In the event of a fire, wear full protective clothing and NIOSH-approved self-contained breathing apparatus with full face piece operated in the pressure demand or other positive pressure mode. At high temperatures under fire conditions, it may produce toxic or irritating fumes. Fire-extinguishing work is done from the windward and the suitable fire-extinguishing method according to the surrounding situation is used. Uninvolved persons should evacuate to a safe place.

Personal precautions, protective equipment, and emergency procedures: Avoid breathing dust/fumes/gas/mist/vapors/spray. Use individual protective equipment (waterproof boots, suitable protective clothing, safety glasses, etc.). Restrict unprotected personnel from the area. Prevent any contact with hot surfaces. Do not approach facing the wind. Do not touch the spilled material.
Environmental precautions: Do not let the product enter drains, soil, or water sources.
Methods and materials used for containment cleanup procedures and Storage: Avoid touching the spilled material. Contain spilled material. Do not let the product enter drains. Use a shovel to put the material into a convenient waste disposal container. Do not contaminate the environment.

Precautions for safe handling: Apply according to good manufacturing and industrial hygiene practices. Ensure proper ventilation. Do not ingest. Do not breathe dust. Wear suitable protective clothing. In case of insufficient ventilation, wear suitable respiratory equipment. Wash thoroughly after handling. Do not drink, eat, or smoke while handling. Avoid contact with skin, eyes, and clothing. Minimize dust generation. Avoid breathing dust/fumes/gas/mist/vapors/spray. Avoid contact with eyes, skin, and clothing. Keep container tightly closed. Avoid ingestion and inhalation. Use individual protective equipment (waterproof boots, suitable protective clothing, safety glasses, etc.). Prevent any contact with hot surfaces.
Conditions for safe storage, including any incompatibilities: Store in cool, dry, and ventilated area away from heat sources and protected from sunlight in tightly closed original container. Keep air contact to a minimum. Do not leave the material container open. Store protected from heat, sparks and ignition sources and incompatible materials. Avoid contact with skin and eyes. Avoid inhalation of dust/mist/vapor. Do not store with incompatible materials like strong oxidizing agents.

Airborne Exposure Limits: TWA 0.5 mg/m3 USA, Occupational Exposure Limits, (OSHA) - Table Z-1 Limits for Air Contaminants.
Ventilation System: A system of local and/or general exhaust is recommended to keep employee exposures as low as possible. Local exhaust ventilation is generally preferred because it can control the emissions of the contaminant at its source, preventing dispersion of it into the general work area.
Personal Respirators (NIOSH Approved): For conditions of use where exposure to dust or mist is apparent and engineering controls are not feasible, a particulate respirator may be worn. For emergencies or instances where the exposure levels are not known, use a full-face positive-pressure, air-supplied respirator.
Skin Protection: Wear protective gloves and clean body-covering clothing.
Eye Protection: Use chemical safety goggles and/or full face shield where dusting or splashing of solutions is possible. Maintain eye wash fountain and quick-drench facilities in work area.
Other Control Measures: Maintain good housekeeping in work area. Dust deposits on floors and other surfaces may pick up moisture and cause the surfaces to become slippery and present safety hazards. Handle in accordance with good industrial hygiene and safety practice. Wash hands after handling.

Appearance: Solid white powder or lumps.
Odor: It is odorless.
Odor threshold: Not available.
pH: <1 @ 50g/liter.
Relative density: Not available.
Melting point/freezing point: Not available.
Initial boiling point and boiling range: Not available.
Flash point: Not available.
Auto-ignition temperature: Not available.
Decomposition temperature: Not available.
Upper/lower flammability or explosive limits: Not available.
Vapor pressure: Not available.
Vapor density: Not available.
Evaporation rate: Not available.
Flammability (solid, gas): Not available.
Partition coefficient: n-octanol/water: Not available.
Solubility(ies): Not available.
Viscosity: Not available.

Stability: Stable under ordinary conditions of use and storage.
Hazardous Decomposition Products: It emits fumes, oxides of carbon and antimony oxide when heated to decomposition.
Hazardous Polymerization: Will not occur.
Incompatibilities: Strong oxidizing agents.
Conditions to Avoid: Incompatibles heat and moisture.

Toxicity data
LD50 Intraperitoneal - Mouse - 33 mg/kg
Carcinogenic Effects: No component of this product present at levels greater than or equal to 0.1% is identified as probable, possible, or confirmed human carcinogen by IARC, ACGIH, NTP, OSHA.
Mutagenic Effects: Not available.
Teratogenic Effects: Not available.
Developmental Toxicity: Not available.

Environmental Toxicity: It is toxic to fish. Harmful to aquatic life in exceptionally low concentrations.
Persistence and Degradability: No information available.
Mobility: No information available.
Bioaccumulation/ Accumulation: No information available.
Results of PBT and vPvB assessment: No data available for assessment.

Whatever cannot be saved for recovery or recycling should be managed in an appropriate and approved waste disposal facility. Processing use or contamination of this product may change the waste management options. State and local disposal regulations may differ from federal disposal regulations. Dispose of container and unused contents in accordance with law.

Land Transport DOT USA, TDG Canada & ADR/RID Europe: Not dangerous goods.
Sea Transport IMO/IMDG: Not dangerous goods.
Air Transport ICAO/IATA: Not dangerous goods.

USA:
SARA 311/312 Hazards: Acute Health Hazard. See section 2.
California Prop. 65 Components: This product does not contain any chemicals known to State of California to cause cancer, birth defects, or any other reproductive harm.

Sodium Stibogluconate Manufacturers, Suppliers, Exporters, Wholesalers:

Plot No. 2900/46&47 + 2900/163to167, GIDC, Ankleshwar, Dist. Bharuch, India
India, USA, UAE
TEL: (Office) 91-22-23774610, 91-22-23723564

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If I sign an “Agreement” my Lawyer will undo it

Our products are for industrial and laboratory use only. The user must test the material before use. We are not dispensing chemists or druggist and do not offer over the counter type (OTC) products for medical use by individuals. Check.

Specifications, Properties, Uses, SDS of Sodium Stibogluconate BP Ph Eur Grade Manufacturer Supplier Exporter Wholesale & Small Packs, CAS Number 16037-91-5.

Sodium Stibogluconate Manufacturers, Suppliers, Exporters, Wholesalers: