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Specifications, Properties, Uses, SDS of Methylparaben or Methyl Hydroxybenzoate or Methyl Paraben USP NF BP Ph Eur FCC Food Grade Manufacturer Supplier Exporter Wholesale & Small Packs, CAS Number 99-76-3. |
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Muby Chem Pvt. Ltd. is a several decades old group of companies, engaged in manufacturing, supplying, distributing, wholesale supplies of Methylparaben or Methyl Hydroxybenzoate or Methyl Paraben for actual users, including retail or small pack supplies for research and development work.
We supply fine and speciality chemicals, pharmaceutical excipients, mineral fortifiers in chemically pure, analytical reagent grade, IP BP USP Ph Eur EP JP and other pharmaceutical grade monograph including FCC Food grade chemicals and Nutraceuticals at best prices. We and/or our associated units have all the facilities to supply as per cGMP standard observing good manufacturing practice and good laboratory practice. We can assure low microbial count and also offer a test certificate for the same. We maintain warehouses across USA, India, and UAE. Our group exports to USA, Canada, Mexico, Argentina, Brazil, Chile, Korea, Malaysia, Thailand, Indonesia, Europe, and several other parts of the world. We supply in wholesale container loads to small pack of few grams. Solid products may be specified for it size and shape as desired by the buyer.
Methylparaben or Methyl Hydroxybenzoate or Methyl Paraben CAS Number 99-76-3
For Properties Specifications Uses of Methylparaben or Methyl Hydroxybenzoate or Methyl Paraben Click Properties, Specifications, Uses, Price, Process of Methylparaben or Methyl Hydroxybenzoate or Methyl Paraben Manufacturer.
For For SDS MSDS Sheet of Methylparaben or Methyl Hydroxybenzoate or Methyl Paraben Click SDS Safety Data Sheet MSDS Sheet of Methylparaben or Methyl Hydroxybenzoate or Methyl Paraben Manufacturer.
The Properties, Specifications, Monograph and Uses of Methylparaben or Methyl Hydroxybenzoate or Methyl Paraben:
CAS Number: 99-76-3, EINECS EC Number: 202-785-7, Molecular Formula: C8H8O3, Molecular Weight: 152.15, HS Code 29181190 or 29182990 or 29163190
Methylparaben or Methyl Hydroxybenzoate or Methyl Paraben is a 4-hydroxybenzoate ester resulting from the formal condensation of the carboxy group of 4-hydroxybenzoic acid with methanol. It is the most frequently used antimicrobial preservative in cosmetics. It has a role as a plant metabolite, an antimicrobial food preservative, a neuroprotective agent and an antifungal agent. Methylparaben is a type of paraben that is used as preservatives to give products a longer shelf life. It is also used as a food preservative and has the E number E218.
Methylparaben USP NF Grade Specifications:
C8H8O3 --- 152.15
Benzoic acid, 4-hydroxy-, methyl ester;
Methyl p-hydroxybenzoate --- CAS 99-76-3
DEFINITION
Methylparaben contains NLT 98.0% and NMT 102.0% of C8H8O3.
IDENTIFICATION
A. Infrared Absorption
B. Melting Range or Temperature: 125C to 128C.
Organic Impurities: To pass the test by Chromatography.
Color of Solution:
Sample solution: 100 mg/mL in alcohol
Comparison solution: Mix 2.4 mL of ferric chloride CS, 1.0 mL of cobaltous chloride CS, and 0.4 mL of cupric sulfate CS with 0.3 N hydrochloric acid to make 10 mL. Dilute 5 mL of this solution with 0.3 N hydrochloric acid to make 100 mL. [Note: Prepare and use this solution immediately.]
Analysis
Samples: Alcohol, Sample solution, and Comparison solution
Make the comparison by viewing the solutions downward in matched color-comparison tubes against a white surface.
Acceptance criteria: The Sample solution is clear and not more intensely colored than alcohol or the Comparison solution.
Acidity:
Sample solution: To 2 mL of the Sample solution prepared in the test for Color of Solution, add 3 mL of alcohol, 5 mL of carbon dioxide-free water, and 0.1 mL of bromocresol green.
Analysis: Titrate with 0.10 N sodium hydroxide.
Acceptance criteria: NMT 0.1 mL is required to produce a blue color.
Packaging and Storage: Preserve in well-closed containers.
Methyl Hydroxybenzoate BP Grade Specifications
Methylparaben
Methyl Parahydroxybenzoate, Ph Eur
C8H8O3 --- 152.1 --- CAS 99-763-3
Action and use: Antimicrobial preservative.
DEFINITION
Methyl 4-hydroxybenzoate.
Content: 98.0 per cent to 102.0 per cent.
CHARACTERS
Appearance: White or almost white, crystalline powder or colourless crystals.
Solubility: Very slightly soluble in water, freely soluble in alcohol and in methanol.
IDENTIFICATION
First identification A, B.
Second identification A, C, D.
A. Melting point: 125C to 128C.
B. Infrared absorption spectrophotometry. Comparison methyl parahydroxybenzoate CRS.
C. Examine the chromatograms obtained in the test for related substances.
Results: The principal spot in the chromatogram obtained with test solution (b) is similar in position and size to the principal spot in the chromatogram obtained with reference solution (b).
D. To about 10 mg in a test-tube add 1 ml of sodium carbonate solution, boil for 30 s and cool (solution A). To a further 10 mg in a similar test-tube add 1 ml of sodium carbonate solution; the substance partly dissolves (solution B). Add at the same time to solution A and solution B 5 ml of aminopyrazolone solution and 1 ml of potassium ferricyanide solution and mix. Solution B is yellow to orange-brown. Solution A is orange to red, the colour being clearly more intense than any similar colour which may be obtained with solution B.
TESTS
Solution S: Dissolve 1.0 g in alcohol and dilute to 10 ml with the same solvent.
Appearance of solution: Solution S is clear and not more intensely coloured than reference solution.
Acidity: To 2 ml of solution S add 3 ml of alcohol, 5 ml of carbon dioxide-free water and 0.1 ml of bromocresol green solution. Not more than 0.1 ml of 0.1 M sodium hydroxide is required to change the colour of the indicator to blue.
Related substances: To pass the test (0.5 per cent).
Sulphated ash: Maximum 0.1 per cent, determined on 1.0 g.
IMPURITIES
A. R = H: 4-hydroxybenzoic acid,
B. R = CH2-CH3: ethyl 4-hydroxybenzoate,
C. R = CH2-CH2-CH3: propyl 4-hydroxybenzoate,
D. R = CH2-CH2-CH2-CH3: butyl 4-hydroxybenzoate.
Specifications of Methylparaben FCC Food Grade
Methyl p-Hydroxybenzoate
HO COOCH3
C8H8O3 Formula wt 152.15
INS: 218 CAS: 99-76-3
DESCRIPTION
Methylparaben occurs as small, colorless crystals or as a white, crystalline powder. One gram dissolves in about 400 mL of water at 25C, in about 50 mL of water at 80C, in about 2.5 mL of alcohol, in about 7 mL of ether, and in about 4 mL of propylene glycol. It is slightly soluble in glycerin and in fixed oils.
Function: Preservative; antimicrobial agent.
Identification: Dissolve 500 mg of sample in 10 mL of 1 N sodium hydroxide, boil for 30 min, allow the solution to evaporate to a volume of about 5 mL, and cool. Acidify the solution with 2 N sulfuric acid, collect the crystals on a filter, wash several times with small portions of water, and dry in a desiccator over silica gel. The p-hydroxybenzoic acid so obtained melts between 212C and 217C.
Assay: Not less than 99.0% and not more than 100.5% of C8H8O3, calculated on the dried basis.
Acidity: Passes test.
Lead: Not more than 2 mg/kg.
Loss on Drying: Not more than 0.5%.
Melting Range: Between 125C and 128C.
Residue on Ignition: Not more than 0.05%.
The MSDS-SDS Hazard Statement of Methylparaben or Methyl Hydroxybenzoate or Methyl Paraben:
Methyl Paraben or Methylparaben SDS, Safety Data Sheet
MSDS Sheet, Material Safety Data Sheet 21-Jul-21
1. Product Identification
Product Name & Other Names: Methyl Paraben, Methylparaben, Methyl 4-Hydroxybenzoate.
CAS No.: 99-76-3
EINECS EC Number: 202-785-7
Molecular Formula: C8H8O3
Molecular Weight: 152.15
Relevant uses and uses advised against (if any): Industrial Manufacturing.
Suppliers: As per letterhead.
2. Hazards Identification
GHS, Globally Harmonized System Classification in accordance with 29 CFR 1910
Classification according to Regulation (EC) No 1272/2008
Skin irritation Category 2, H315
Serious eye damage/eye irritation Category 2A, H319
Specific target organ toxicity - single exposure, Target Organs - Respiratory system. Category 3, H335
Labelling according to Regulation (EC) No 1272/2008
GHS Label Elements  Irritant |
Signal Words: Warning
Hazard statements:
H315: Causes skin irritation.
H319: Causes serious eye irritation.
H335: May cause respiratory irritation.
Precautionary statements:
P264: Wash … thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P332+P313: If skin irritation occurs: Get medical advice/attention.
P337+P313: If eye irritation persists: Get medical advice/ attention.
P362: Take off contaminated clothing and wash before reuse.
3. Composition/Information on Ingredients
Product Name & Other Names: Methyl Paraben, Methylparaben, Methyl 4-Hydroxybenzoate.
CAS No.: 99-76-3
EINECS EC Number: 202-785-7
4. First Aid Measures
Always seek medical attention after first aid measures are provided.
Inhalation: If inhaled, remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen and get medical attention immediately.
Ingestion: Never give anything by mouth to an unconscious person. Get medical attention.
Skin Contact: Immediately flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes. Get medical attention. Wash clothing and shoes before reuse.
Eye Contact: Immediately flush eyes with plenty of water for at least 15 minutes, lifting lower and upper eyelids occasionally. Get medical attention immediately.
5. Fire Fighting Measures
Fire: As with most organic solids, fire is possible at elevated temperatures or by contact with an ignition source.
Explosion: Fine dust dispersed in air in sufficient concentrations, and in the presence of an ignition source is a potential dust explosion hazard.
Fire Extinguishing Media: Water spray, dry chemical, alcohol foam, or carbon dioxide.
Hazardous decomposition products formed under fire conditions: Carbon oxides.
Extinguishing Media Not recommended: Avoid using solid water jet as it may scatter the fire.
Special Information: In the event of a fire, wear full protective clothing and NIOSH-approved self-contained breathing apparatus with full face piece operated in the pressure demand or other positive pressure mode. At high temperatures under fire conditions, it may produce toxic or irritating fumes. Fire-extinguishing work is done from the windward and the suitable fire-extinguishing method according to the surrounding situation is used. Uninvolved persons should evacuate to a safe place.
6. Accidental Release Measures
Personal precautions, protective equipment, and emergency procedures: Avoid breathing dust/fumes/gas/mist/vapors/spray. Ensure adequate ventilation. Use individual protective equipment (waterproof boots, suitable protective clothing, safety glasses, etc.). Restrict unprotected personnel from the area. Prevent any contact with hot surfaces. Do not approach facing the wind. Do not touch the spilled material.
Environmental precautions: Do not let the product enter drains, soil, or water sources.
Methods and materials used for containment cleanup procedures and Storage: Contain spilled material. Pick up or sweep and place in suitable disposal container. Stop leak if without risk. Do not get water inside container. Do not touch spilled material. Use water spray to reduce vapors. Prevent entry into sewers, basements, or confined areas; dike if needed. Eliminate all ignition sources.
7. Handling and Storage
Precautions for safe handling: Apply according to good manufacturing and industrial hygiene practices. Ensure proper ventilation. Wash thoroughly after handling. Do not drink, eat, or smoke while handling. Avoid contact with skin, eyes, and clothing. Minimize dust generation. Avoid breathing dust/fumes/gas/mist/vapors/spray. Avoid contact with eyes, skin, and clothing. Keep container tightly closed. Avoid ingestion and inhalation. Use individual protective equipment (waterproof boots, suitable protective clothing, safety glasses, etc.). Prevent any contact with hot surfaces.
Conditions for safe storage, including any incompatibilities: Store in cool, dry, and ventilated area away from heat sources and protected from sunlight in tightly closed original container. Keep air contact to a minimum. Do not leave the material container open. Store protected from heat, sparks and ignition sources and incompatible materials. Avoid contact with skin and eyes. Avoid inhalation of dust/mist/vapor. Do not store with incompatible materials like strong oxidizers, acids, and bases. May form combustible dust concentrations in air. Use care during processing to minimize generation of dust. Containers may be hazardous when empty. Avoid dust formation and control ignition sources. Employ grounding, venting and explosion relief provisions in accord with accepted engineering practices in any process capable of generating dust and/or static electricity.
8. Exposure Controls/Personal Protection
Airborne Exposure Limits: None established.
Ventilation System: A system of local and/or general exhaust is recommended to keep employee exposures as low as possible. Local exhaust ventilation is generally preferred because it can control the emissions of the contaminant at its source, preventing dispersion of it into the general work area. Please refer to the ACGIH document, Industrial Ventilation, A Manual of Recommended Practices, most recent edition, for details.
Personal Respirators (NIOSH Approved): For conditions of use where exposure to dust or mist is apparent and engineering controls are not feasible, a particulate respirator (NIOSH type N95 or better filters) may be worn. If oil particles (e.g., lubricants, cutting fluids, glycerin, etc.) are present, use a NIOSH type R or P filter. For emergencies or instances where the exposure levels are not known, use a full-face positive-pressure, air-supplied respirator. WARNING: Air-purifying respirators do not protect workers in oxygen-deficient atmospheres.
Skin Protection: Wear impervious protective clothing, including boots, gloves, lab coat, apron, or coveralls, as appropriate, to prevent skin contact.
Eye Protection: Use chemical safety goggles and/or full-face shield where dusting or splashing of solutions is possible. Maintain eye wash fountain and quick-drench facilities in work area.
Other Control Measures: Maintain good housekeeping in work area. Dust deposits on floors and other surfaces may pick up moisture and cause the surfaces to become slippery and present safety hazards. Handle in accordance with good industrial hygiene and safety practice. Wash hands after handling.
9. Physical and Chemical Properties
Appearance: White crystals or powder.
Odor: Odorless.
Odor threshold: Not available.
pH: 1.0 - 2 at 150 g/l at 25C (77F).
Relative density: 1.38
Boiling Point: 270-280C
Melting Point: 125-131C
Flash point: Not available.
Auto-ignition Temperature: > 403C
Decomposition temperature: Not available.
Upper/lower flammability or explosive limits: Not available.
Vapor pressure: Not available.
Vapor Density (Air=1): 5.23
Evaporation rate: Not available.
Flammability (solid, gas): Not available.
Partition coefficient: n-octanol/water: Not available.
Solubility: Slightly soluble in water.
Viscosity: Not available.
Molecular Formula: C8H8O3
Molecular Weight: 152.15
10. Stability and Reactivity
Stability: Stable under ordinary conditions of use and storage.
Hazardous Decomposition Products: Carbon dioxide and carbon monoxide may form when heated to decomposition.
Hazardous Polymerization: Will not occur.
Incompatibilities: Strong oxidizers, acids, and bases.
Conditions to Avoid: Direct sunlight. Extremely high or low temperatures, Heat, dusting, and incompatibles.
11. Toxicological Information
LD50 oral rat: 2100 mg/kg
LD50 Oral mouse: > 8,000 mg/kg
LD50 dermal rat: NA
LD50 Intravenous - mouse - 485 mg/kg
LD 50 Oral Rabbit: 6000 mg/kg
Carcinogenicity: Not know to be or anticipated to be a carcinogen.
Mutagenic Effects: Not available.
Developmental Toxicity: Not available.
Reproductive Effects: No information available.
Teratogenicity: no data available.
12. Ecological Information
EC50 Daphnia: 0.56 mg/l.
LC50 Fish: 59.5 mg/l
Results of PBT and vPvB assessment: This substance/mixture contains no components considered to be either persistent, bioaccumulative and toxic (PBT), or very persistent and very bioaccumulative (vPvB) at levels of 0.1% or higher.
Mobility in soil: No data available.
13. Disposal Considerations
Whatever cannot be saved for recovery or recycling should be managed in an appropriate and approved waste disposal facility. Processing use or contamination of this product may change the waste management options. State and local disposal regulations may differ from federal disposal regulations. Dispose of container and unused material in accordance with legal requirements.
14. Transport Information
Land Transport DOT USA, TDG Canada & ADR/RID Europe: Not dangerous goods.
Sea Transport IMO/IMDG: Not dangerous goods.
Air Transport ICAO/IATA: Not dangerous goods.
15. Regulatory Information
USA:
SARA 311/312 Hazards: Acute Health Hazard
California Prop. 65 Components: This product does not contain any chemicals known to State of California to cause cancer, birth defects, or any other reproductive harm.
Section 16 - Additional Information
DISCLAIMER: The information and recommendations set forth herein are presented in good faith and believed correct as of the date hereof. It is compiled from various sources, and it is not necessarily all inclusive nor fully adequate in every circumstance. In addition, these suggestions should not be confused with nor followed in violation of applicable laws, regulations, rules, or insurance requirements applicable. This SDS MSDS sheet is intended only as a guide to the appropriate precautionary handling of the material by a professionally trained person using this product. Individuals receiving the information must exercise their independent judgment in determining its appropriateness for a particular purpose. This shall not constitute a guarantee for any specific product features and shall not establish a legally valid contractual relationship. In no case shall our company be liable to loss or damages by the product user.
Methylparaben or Methyl Hydroxybenzoate or Methyl Paraben Manufacturers, Suppliers, Exporters, Wholesalers:
King of Chemicals manufacturers
Plot No. 2900/46&47 + 2900/163to167, GIDC, Ankleshwar, Dist. Bharuch, India
India, USA, UAE
TEL: (Office) 91-22-23774610, 91-22-23723564
e-mail: info@kingofchemicals.com
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