Specifications, Uses, SDS of Methylene Blue Manufacturers

	King of Chemicals
Specifications, Properties, Uses, SDS of Methylene Blue or Methylthioninium Chloride USP BP Ph Eur Grade Manufacturer Supplier Exporter Wholesale & Small Packs, CAS Number Pentahydrate 32680-41-4, Trihydrate 7220-79-3, Monohydrate 122965-43-9 & Anhydrous 61-73-4.
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Muby Chem Pvt. Ltd. is a several decades old group of companies, engaged in manufacturing, supplying, distributing, wholesale supplies of Methylene Blue or Methylthioninium Chloride for actual users, including retail or small pack supplies for research and development work.

We supply fine and speciality chemicals, pharmaceutical excipients, mineral fortifiers in chemically pure, analytical reagent grade, IP BP USP Ph Eur EP JP and other pharmaceutical grade monograph including FCC Food grade chemicals and Nutraceuticals at best prices. We and/or our associated units have all the facilities to supply as per cGMP standard observing good manufacturing practice and good laboratory practice. We can assure low microbial count and also offer a test certificate for the same. We maintain warehouses across USA, India, and UAE. Our group exports to USA, Canada, Mexico, Argentina, Brazil, Chile, Korea, Malaysia, Thailand, Indonesia, Europe, and several other parts of the world. We supply in wholesale container loads to small pack of few grams. Solid products may be specified for it size and shape as desired by the buyer.

Methylene Blue Manufacturer Supplier Exporter

Methylene Blue or Methylthioninium Chloride CAS Number Pentahydrate 32680-41-4, Trihydrate 7220-79-3, Monohydrate 122965-43-9 & Anhydrous 61-73-4, EC EINECS 200-515-2

The Properties, Specifications, Monograph and Uses of Methylene Blue or Methylthioninium Chloride:

CAS Number Trihydrate 7220-79-3 & Anhydrous 61-73-4, EC EINECS 200-515-2, HS Code 32041351 or 38220090,Molecular Weight 373.9, Chemical Formula: C16H18ClN3S-3H2O

Methylene Blue USP Grade Specifications:
C16H18ClN3S-xH2O
Phenothiazin-5-ium, 3,7-bis(dimethylamino)-, chloride;
3,7-Bis(dimethylamino)phenothiazin-5-ium chloride;
Pentahydrate --- 409.93 --- CAS 32680-41-4
Trihydrate --- 373.90 --- CAS 7220-79-3
Monohydrate --- 337.90 --- 122965-43-9
Anhydrous --- 319.85 --- 61-73-4.

DEFINITION
Methylene Blue contains NLT 97.0% ;and NMT 103.0% of methylene blue (C16H18ClN3S), calculated on the dried basis.

IDENTIFICATION
A. Infrared Absorption.
B. The retention time of the major peak of the Sample solution corresponds to that of the Standard solution, as obtained in the Assay.
C. Identification Tests—General Chloride.

Methylthioninium Chloride BP Ph Eur Grade Specifications:
C16H18ClN3S,xH2O --- 319.9 (anhydrous substance)
Action and use: Reducing agent; antidote to methaemoglobinaemia.

DEFINITION
3,7-Bis(dimethylamino)phenothiazin-5-ylium chloride (methylene blue).
Content: 93.0 per cent to 102.0 per cent (dried substance).
It contains a variable quantity of water.

CHARACTERS
Appearance: Dark blue or dark green crystalline powder with a metallic sheen, hygroscopic.
Solubility: Slightly soluble in water and in ethanol (96 per cent).

IDENTIFICATION
A. Ultraviolet and visible absorption spectrophotometry. To pass the test.
B. Thin-layer chromatography. To pass the test.
C. Ignite 50 mg with 0.5 g of anhydrous sodium carbonate. Cool and dissolve the residue in 10 mL of dilute nitric acid. Filter. The filtrate, without further addition of dilute nitric acid, gives reaction (a) of chlorides.

TESTS
Related substances: To pass the test by Liquid chromatography.
Metals: To pass the test.
Loss on drying: 8.0 per cent to 24.0 per cent, determined on 1.000 g by drying in an oven at 105C for 5 h.
Sulfated ash: Maximum 0.25 per cent, determined on 1.0 g.

The MSDS-SDS Hazard Statement of Methylene Blue or Methylthioninium Chloride:

Methylene Blue or Methylthioninium Chloride SDS, Safety Data Sheet
MSDS Sheet, Material Safety Data Sheet 21-Jul-21

Product Name & Other Names: Methylene Blue or Basic Blue 9,trihydrate or Methylene blue trihydrate or 3,7-Bis(dimethylamino)phenazathionium chloride trihydrate or Methylthioninium Chloride.
CAS No.: Pentahydrate 32680-41-4, Trihydrate 7220-79-3, Monohydrate 122965-43-9 & Anhydrous 61-73-4
EINECS EC Number: 200-515-2
Molecular Weight: 373.91 for Trihydrate
Chemical Formula: C16H18ClN3S-3H2O
Relevant uses and uses advised against (if any): Industrial Manufacturing.
Suppliers: As per letterhead.

GHS, Globally Harmonized System Classification in accordance with 29 CFR 1910
Classification according to Regulation (EC) No 1272/2008

Acute toxicity, oral Category 4, H302
Skin corrosion/irritation Category 2, H315
Serious eye damage/eye irritation Category 2A, H319
Specific target organ toxicity, single exposure; Respiratory tract irritation Category 3, H335

Hazard statements:
H302: Harmful if swallowed.
H315: Causes skin irritation.
H319: Causes serious eye irritation.
H335: May cause respiratory irritation.

P262: Do not get in eyes, on skin, or on clothing.
P264: Wash skin thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P270: Do not eat, drink or smoke when using this product.
P273: Avoid release to the environment.
P330: Rinse mouth.
P362: Take off contaminated clothing and wash before reuse.
P301+312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell.
P332+313: If skin irritation occurs: Get medical advice/attention.
P302+ P352 - IF ON SKIN: Wash with plenty of soap and water.
P305+ P351 + P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P332+313: If skin irritation occurs: Get medical advice/attention.
P337+P313 If eye irritation persists: Get medical advice/ attention.
P501: Dispose of contents/container to authorized agents only.

Inhalation: Remove to fresh air. Give oxygen if breathing is difficult; give artificial respiration if breathing has stopped. Keep person warm and quiet; get medical attention.
Ingestion: Induce vomiting immediately as directed by medical personnel. Never give anything by mouth to an unconscious person.
Skin Contact: Immediately flush skin with plenty of soap and water for at least 15 minutes. Remove contaminated clothing and shoes. Wash clothing before reuse. Thoroughly clean shoes before reuse. Get medical attention if irritation develops.
Eye Contact: Immediately flush eyes with plenty of water for at least 15 minutes, lifting upper and lower eyelids occasionally. Get medical attention.

Fire: May become a fire hazard at high temperatures.
Fire Extinguishing Media: Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.
Special hazards arising from the substance or mixture: Carbon oxides, Nitrogen oxides (NOx), Sulfur oxides, Hydrogen chloride gas.
Extinguishing Media Not recommended: Avoid using solid water jet as it may scatter the fire.
Special Information: In the event of a fire, wear full protective clothing and NIOSH-approved self-contained breathing apparatus with full face piece operated in the pressure demand or other positive pressure mode. At high temperatures under fire conditions, it may produce toxic or irritating fumes. Fire-extinguishing work is done from the windward and the suitable fire-extinguishing method according to the surrounding situation is used. Uninvolved persons should evacuate to a safe place.

Personal precautions, protective equipment, and emergency procedures: Use personal protective equipment. Avoid dust formation. Avoid breathing dust/fumes/gas/mist/vapors/spray. Use individual protective equipment (waterproof boots, suitable protective clothing, safety glasses, etc.). Restrict unprotected personnel from the area. Prevent any contact with hot surfaces. Do not approach facing the wind. Do not touch the spilled material.
Environmental precautions: Do not let the product enter drains, soil, or water sources.
Methods and materials used for containment cleanup procedures and Storage: Contain spilled material. Cover with an inert, non-combustible absorbent material, (e.g., sand, earth, diatomaceous earth, vermiculite). Vacuum or sweep-up and remove to an approved disposal container.

Precautions for safe handling: Apply according to good manufacturing and industrial hygiene practices. Ensure proper ventilation. Wash thoroughly after handling. Do not drink, eat, or smoke while handling. Avoid contact with skin, eyes, and clothing. Minimize dust generation. Avoid breathing dust/fumes/gas/mist/vapors/spray. Avoid contact with eyes, skin, and clothing. Keep container tightly closed. Avoid ingestion and inhalation. Use individual protective equipment (waterproof boots, suitable protective clothing, safety glasses, etc.). Prevent any contact with hot surfaces.
Conditions for safe storage, including any incompatibilities: Store in cool, dry, and ventilated area away from heat sources and protected from sunlight in tightly closed original container. Keep air contact to a minimum. Do not leave the material container open. Store protected from heat, sparks and ignition sources and incompatible materials. Avoid contact with skin and eyes. Avoid inhalation of dust/mist/vapor. Do not store with incompatible materials like strong oxidizing agents, alkali, dichromates, alkali iodides, reducing agents. Avoid dust formation and control ignition sources. Containers may be hazardous when empty.

Airborne Exposure Limits: None established.
Ventilation System: In general, dilution ventilation is a satisfactory health hazard control for this substance. However, if conditions of use create discomfort to the worker, a local exhaust system should be considered.
Personal Respirators (NIOSH Approved): Not expected to require personal respirator usage. For conditions of use where exposure to dust or mist is apparent and engineering controls are not feasible, a particulate respirator (NIOSH type N95 or better filters) may be worn. If oil particles (e.g., lubricants, cutting fluids, glycerin, etc.) are present, use a NIOSH type R or P filter. For emergencies or instances where the exposure levels are not known, use a full-face positive-pressure, air-supplied respirator.
Skin Protection: Wear protective gloves and clean body-covering clothing.
Eye Protection: Use chemical safety goggles and/or full-face shield where dusting or splashing of solutions is possible. Maintain eye wash fountain and quick-drench facilities in work area.
Other Control Measures: Maintain good housekeeping in work area. Dust deposits on floors and other surfaces may pick up moisture and cause the surfaces to become slippery and present safety hazards. Handle in accordance with good industrial hygiene and safety practice. Wash hands after handling.

Appearance: Methylene Blue is dark green crystals with bronze luster or crystalline powder.
Odor: Odorless.
Odor threshold: Not available.
pH: Not available.
Relative density: Not available.
Boiling Point: Decomposes.
Melting Point: 190C
Flash point: Not available.
Auto-ignition temperature: Not available.
Decomposition temperature: Not available.
Upper/lower flammability or explosive limits: Not available.
Vapor pressure: Not available.
Vapor density: Not available.
Evaporation rate: Not available.
Flammability (solid, gas): Not available.
Partition coefficient: n-octanol/water: Not available.
Solubility: Soluble in water.
Viscosity: Not available.
Molecular Weight: 373.91
Chemical Formula: C16H18ClN3S-3H2O

Stability: Methylene Blue is stable under ordinary conditions of use and storage.
Hazardous Decomposition Products: May produce oxides of nitrogen, sulfur, and carbon along with chlorine compounds when heated to decomposition.
Hazardous Polymerization: Will not occur.
Incompatibilities: Strong oxidizing agents, alkali, dichromates, alkali iodides, reducing agents.
Conditions to Avoid: Heat, flame, ignition sources, dusting and incompatibles.

11. Toxicological InformationMethylene Blue: 1180 mg/kg LD50 oral rat. Investigated as a mutagen, reproductive effector.
Carcinogenic Effects: Not a reported carcinogen by IARC, NTP, ACGIH, OSHA.

Environmental Fate: When released into the soil, this material is not expected to evaporate significantly. When released into water, this material is not expected to evaporate significantly. This material has an estimated bioconcentration factor (BCF) of less than 100. This material is not expected to significantly bioaccumulate. When released into the air, this material is expected to be readily degraded by reaction with photochemically produced hydroxyl radicals. When released into the air, this material may be removed from the atmosphere to a moderate extent by wet deposition. When released into the air, this material may be removed from the atmosphere to a moderate extent by dry deposition.
Results of PBT and vPvB assessment: This substance/mixture contains no components considered to be either persistent, bioaccumulative and toxic (PBT), or very persistent and very bioaccumulative (vPvB) at levels of 0.1% or higher.

Whatever cannot be saved for recovery or recycling should be managed in an appropriate and approved waste disposal facility. Processing use or contamination of this product may change the waste management options. Dispose of container and unused Methylene Blue in accordance with legal requirements.

Land Transport DOT USA, TDG Canada & ADR/RID Europe: Not regulated.
Air Transport IATA/ICAO: Not regulated.
Sea Transport IMDG/IMO: Not regulated.

USA:
SARA 311/312 Hazardous Categorization: Acute Health Hazard, Chronic Health Hazard.
California Proposition 65: This product does not contain any Proposition 65 chemicals.

Methylene Blue or Methylthioninium Chloride Manufacturers, Suppliers, Exporters, Wholesalers:

Plot No. 2900/46&47 + 2900/163to167, GIDC, Ankleshwar, Dist. Bharuch, India
India, USA, UAE
TEL: (Office) 91-22-23774610, 91-22-23723564

If I give you “My Word” Nobody can undo it.
If I sign an “Agreement” my Lawyer will undo it

Our products are for industrial and laboratory use only. The user must test the material before use. We are not dispensing chemists or druggist and do not offer over the counter type (OTC) products for medical use by individuals. Check.

Specifications, Properties, Uses, SDS of Methylene Blue or Methylthioninium Chloride USP BP Ph Eur Grade Manufacturer Supplier Exporter Wholesale & Small Packs, CAS Number Pentahydrate 32680-41-4, Trihydrate 7220-79-3, Monohydrate 122965-43-9 & Anhydrous 61-73-4.

Methylene Blue or Methylthioninium Chloride Manufacturers, Suppliers, Exporters, Wholesalers: