Specifications, Uses, SDS of Ergocalciferol or Vitamin D2 Manufacturers

	King of Chemicals Manufacturers
Specifications, Properties, Uses, Ergocalciferol or Vitamin D2 or Calciferol USP BP Ph Eur FCC Food Grade Manufacturer Supplier Exporter Wholesale & Small Packs, CAS Number 50-14-6.
King of Chemicals has several associated companies having accreditations like cGMP, GLP - FDA Approved Good Manufacturing Practice and Good Laboratory Practice of WHO standard, ISO-9001, ISO-14001, ISO/IEC 17025, ISO ISO-45000, HACCP, FSSC 220000, FSSAI, "REACH" Registered, Kosher & Halal Certified. e-CTD and DMF support can be made available if needed. We offer USP NF BP Ph Eur EP IP JP Analytical Reagent FCC Food Grade Chemicals & Nutraceuticals.

Muby Chem Pvt. Ltd. is a several decades old group of companies, engaged in manufacturing, supplying, distributing, wholesale supplies of Ergocalciferol or Vitamin D2 or Calciferol USP BP Ph Eur FCC Food Grade for actual users, including retail or small pack supplies for research and development work.

We supply fine and speciality chemicals, pharmaceutical excipients, mineral fortifiers in chemically pure, analytical reagent grade, IP BP USP Ph Eur EP JP and other pharmaceutical grade monograph including FCC Food grade chemicals and Nutraceuticals at best prices. We and/or our associated units have all the facilities to supply as per cGMP standard observing good manufacturing practice and good laboratory practice. We can assure low microbial count and also offer a test certificate for the same. We maintain warehouses across USA, India, and UAE. Our group exports to USA, Canada, Mexico, Argentina, Brazil, Chile, Korea, Malaysia, Thailand, Indonesia, Europe, and several other parts of the world. We supply in wholesale container loads to small pack of few grams. Solid products may be specified for it size and shape as desired by the buyer.

The Properties, Specifications, Monograph and Uses of Ergocalciferol or Vitamin D2 or Calciferol:

Ergocalciferol or Vitamin D2 or Calciferol, is a type of vitamin D found in food and used as a dietary supplement. It works by helping the body to use more of the calcium found in foods or supplements.

Ergocalciferol BP Ph Eur Grade Specifications:
C28H44O --- 396.7 CAS 50-14-6
Action and use: Vitamin D analogue (Vitamin D2).

DEFINITION
(5Z,7E,22E)-9,10-Secoergosta-5,7,10(19),22-tetraen-3β-ol.
Content: 96.5 per cent to 102.0 per cent.
A suitable antioxidant may be added.
A reversible isomerisation to pre-ergocalciferol takes place in solution, depending on temperature and time. The activity is due to both compounds.
1 mg of ergocalciferol is equivalent to 40 000 IU of antirachitic activity (vitamin D) in rats.

CHARACTERS
Appearance: White or slightly yellowish, crystalline powder or white or almost white crystals.
Solubility: Practically insoluble in water, freely soluble in ethanol (96 per cent) and in methanol, soluble in fatty oils.
It is sensitive to air, heat and light. Solutions in volatile solvents are unstable and are to be used immediately.

IDENTIFICATION
Infrared absorption spectrophotometry.
Specific optical rotation: + 103 to + 107.
Dissolve 0.200 g rapidly and without heating in aldehyde-free alcohol and dilute to 25.0 mL with the same solvent. Examine within 30 min of preparing the solution.
Reducing substances: to pass the test.
Impurity B: To pass the test by Liquid chromatography. --- 0.2 per cent.
Related substances: To pass the test by Liquid chromatography.
Storage: Under an inert gas, in an airtight container, protected from light, at a temperature of 2C to 8C. The contents of an opened container are to be used immediately.

Ergocalciferol USP Grade Specifications:
C28H44O --- 396.65
9,10-Secoergosta-5,7,10 (19),22-tetraen-3-ol, (3β,5Z ,7E ,22E )-;
Ergocalciferol CAS 50-14-6
UNII: VS041H42XC

DEFINITION
Ergocalciferol contains NLT 97.0% and NMT 103.0% of ergocalciferol (C28H44O).

IDENTIFICATION
A. Infrared Absorption
B. Ultraviolet Absorption
C.
Sample solution: 0.5 mg in 5 mL of chloroform.
Analysis: Add 0.3 mL of acetic anhydride and 0.1 mL of sulfuric acid to the Sample solution and shake vigorously.
Acceptance criteria: A bright red color is produced and rapidly changes through violet and blue to green.
D. Thin-Layer Chromatography: To pass the test.

Reducing Substances: To pass the test.
Melting Range or Temperature: 115C to 119C.
Optical Rotation, Specific Rotation:
Sample solution: 15 mg/mL in alcohol. [Note— Prepare and use the solution without delay. Use Ergocalciferol from a container opened not longer than 30 min.]
Acceptance criteria: +103° to +106°
Packaging and Storage: Preserve in hermetically sealed containers under nitrogen, and store in a cool place protected from light.

Ergocalciferol FCC Food Grade Specifications
Vitamin D2
Ergocalciferol; Vitamin D
C28H44O --- Formula weight 396.66
CAS 50-14-6

DESCRIPTION
Vitamin D2 occurs as white crystals. It is affected by air and by light. It is insoluble in water, but it is soluble in alcohol, in chloroform, in ether, and in fatty oils.
Function: Nutrient.

REQUIREMENTS
Identification:
A. To pass the chromatographic test.
B. The infrared absorption spectrum of a potassium bromide dispersion of the sample, in the range of 2 to 12 µm, exhibits maxima only at the same wavelengths as those of a similar preparation of USP Ergocalciferol Reference Standard.
C. The ultraviolet absorption spectrum of the sample in alcohol solution exhibits inflections at the same wavelengths as that of USP Ergocalciferol Reference Standard, similarly measured, and the respective absorptivities at 265 nm do not differ by more than 3.0%.

Assay: Not less than 97.0% and not more than 103.0% of C28H44O.
Ergosterol: Passes test.
Melting Range: Between 115° and 119°.
Optical (Specific) Rotation [α]D25°: Between +103° and +106°.
Reducing Substances: Passes test.

The MSDS-SDS Hazard Statement of Ergocalciferol or Vitamin D2 or Calciferol:

Ergocalciferol or Vitamin D2 or Calciferol SDS GHS, Safety Data Sheet
MSDS Sheet, Material Safety Data Sheet 09-April-25

Product Name & Other Names: Ergocalciferol or Vitamin D2 or Calciferol.
CAS No.: 50-14-6
EINECS EC No.: 200-014-9
Relevant uses and uses advised against (if any): Industrial Manufacturing.

GHS, Globally Harmonized System Classification in accordance with 29 CFR 1910
Hazard Class and Category Code(s), Regulation (EC) No 1272/2008 (CLP):

Acute toxicity, Oral (Category 3), H301
Acute toxicity, Dermal (Category 3), H311
Acute toxicity, Inhalation (Category 2), H330
Specific target organ toxicity - repeated exposure, Oral (Category 1), H372

Hazard statements:
H301: Toxic if swallowed.
H311: Toxic in contact with skin.
H330: Fatal if inhaled.
H372 Causes damage to organs through prolonged or repeated exposure if swallowed.

P261: Avoid breathing dust/fume/gas/mist/vapors/spray.
P262 Do not get in eyes, on skin, or on clothing.
P264: Wash --- thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P271: Use only outdoors or in a well-ventilated area.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
P330: Rinse mouth.
P304+340+310: IF INHALED: Remove person to fresh air and keep comfortable for breathing. Immediately call a POISON CENTER/doctor.
P305+351+338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do – continue rinsing.

Product Name & Other Names: Ergocalciferol or Vitamin D2 or Calciferol.
CAS No.: 50-14-6
EINECS EC No.: 200-014-9

Inhalation: Remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical attention.
Ingestion: Never give anything by mouth to an unconscious person. Get medical attention.
Skin Contact: Wipe off excess material from skin then immediately flush skin with plenty of water for at least 15 minutes. Remove contaminated clothing and shoes. Get medical attention.
Eye Contact: Immediately flush eyes with plenty of water for at least 15 minutes, lifting lower and upper eyelids occasionally. Get medical attention immediately.

Products of Combustion: Carbon dioxide, Carbon monoxide and fumes.
Explosion: May be explosive in presence of heat.
Fire Extinguishing Media: Use dry powder or dry sand should be preferred. Do not use solid water stream. Flammable liquid and vapor. For small (incipient) fires, use media such as "alcohol" foam, dry chemical, or carbon dioxide. For large fires, apply water from as far as possible. Use large quantities (flooding) of water applied as a mist or spray. Vapors are heavier than air and may travel to a source of ignition and flash back. Vapors can spread along the ground and collect in low or confined areas. Never direct a water jet in the container to prevent any splashing of the product which could cause spreading of the fire. Cool containing vessels with water jet to prevent pressure build-up, auto-ignition, or explosion.
Special Information: In the event of a fire, wear full protective clothing and NIOSH-approved self-contained breathing apparatus with full face piece operated in the pressure demand or other positive pressure mode. At high temperatures under fire conditions, it may produce toxic or irritating fumes.

Personal precautions, protective equipment, and emergency procedures: Avoid breathing dust/fumes/gas/mist/vapors/spray. Use individual protective equipment (waterproof boots, suitable protective clothing, safety glasses, etc.).
Environmental precautions: Do not let the product enter drains, soil, or water sources.
Methods and materials used for containment cleanup procedures and Storage:
Remove all sources of ignition. Provide proper ventilation. Keep people away from upwind of spill/leak. Entry to non-involved personnel should be controlled around the leakage area by roping off. Absorb the material on a porous, inert material such as earth, sand, or vermiculite. Carefully sweep up the material without causing dust. Dispose it of in accordance with local regulations.
Large spillages should be contained by use of sand or another inert material. The spillage should be transferred to a suitable container and recovered or disposed of in accordance with local regulations. Because of the danger of spontaneous combustion, any combustible material, such as cloth, used for cleaning spillages, should be saturated with water, and disposed of promptly, preferably by incineration.

Precautions for safe handling: Apply according to good manufacturing and industrial hygiene practices. Ensure proper ventilation. Wash thoroughly after handling. Do not drink, eat, or smoke while handling. Avoid contact with skin, eyes, and clothing. Minimize dust generation. Avoid breathing dust/fumes/gas/mist/vapors/spray. Keep container tightly closed. Avoid ingestion and inhalation. Use individual protective equipment (waterproof boots, suitable protective clothing, safety glasses, etc.). Wear suitable protective clothing. In case of insufficient ventilation, wear suitable respiratory equipment. Keep away from heat/sparks/open flame/hot surfaces.
Conditions for safe storage, including any incompatibilities: Store in cool, dry, and ventilated area away from heat sources and protected from sunlight in tightly closed original container. Keep air contact to a minimum. Do not leave the material container open. Store protected from light, heat, sparks and ignition sources and incompatible materials. Avoid inhalation of dust/mist/vapor. Do not store with incompatible materials like oxidizing agents, acids, bases. Store locked up. Storage: 2C to 8C.

Airborne Exposure Limits: Not Established.
Ventilation System: A system of local and/or general exhaust is recommended to keep employee exposures as low as possible.
Personal Respirators (NIOSH Approved): For conditions of use where exposure to dust or mist is apparent and engineering controls are not feasible, a particulate respirator may be worn.
Skin Protection: Wear protective gloves and clean body-covering clothing.
Eye Protection: Use chemical safety goggles and/or full-face shield where dusting or splashing of solutions is possible. Maintain eye wash fountain and quick-drench facilities in work area.
Other Control Measures: Maintain good housekeeping in work area. Handle in accordance with good industrial hygiene and safety practice.

Appearance: White or slightly yellowish, crystalline powder or white or almost white crystals..
Odor: No data found.
Odor threshold: No data found.
pH: No data found.
Relative density: No data found.
Boiling Point: No data found.
Melting Point: 115C to 119C.
Flash Point: No data found.
Auto-ignition temperature: No data found.
Decomposition temperature: No data found.
Upper/lower flammability or explosive limits: No data found.
Vapor pressure: No data found.
Vapor density: No data found.
Evaporation rate: No data found.
Flammability (solid, gas): No data found.
Partition coefficient: n-octanol/water: No data found.
Solubility: No data found.
Viscosity: No data found.

Stability: Stable under ordinary conditions of use and storage. Vapour/air-mixtures are explosive at high temperature.
Hazardous Decomposition Products: It emits Carbon oxides and Fumes.
Hazardous Polymerization: Will not occur.
Incompatibilities: Strong oxidizing agents, Acids, Bases.
Conditions to Avoid: Incompatibles, heat flame & light.

Fatal if inhaled, swallowed and in skin contact.
LD50 Oral - Rat – 10 mg/kg.
Carcinogenicity: No data found.
Epidemiology: No data found.
Teratogenicity: No data found.
Reproductive Effects: No data found.
Mutagenicity: No data found.
Neurotoxicity: No data found.

Environmental Toxicity: No data found.
Environmental Fate: No data found.
Mobility: No data found.
Persistence and Degradability: No data found.
Toxicity of the Products of Biodegradation: No data found.

Whatever cannot be saved for recovery or recycling should be managed in an appropriate and approved waste disposal facility. Follow all the pollution control rules.

DOT USA, TDG Canada & ADR/RID Europe:
Shipping Name: Toxic solid, organic. (ergocalciferol; Vitamin D2).
Hazard Class: 6.1, Packing Group: II.
UN Number: UN2811
IATA & IMDG/IMO:
Shipping Name: Toxic solid, organic. (ergocalciferol; Vitamin D2).
Hazard Class: 6.1, Packing Group: II.

USA:
SARA 311/312 Hazards: Chronic Health Hazard.
California prop. 65: Not listed.

Disclaimer:
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Our company provides this MSDS sheet in good faith but makes no representation as to its comprehensiveness or accuracy. This SDS sheet is intended only as a guide to the appropriate precautionary handling of the material by a properly trained person using this product. The above information has been compiled from various sources and has the possibility of discrepancy and being out-dated information. Individuals receiving the information must exercise their independent judgment and do further search in determining its appropriateness for a particular purpose. In no case shall our company be liable to loss or damages by the product user.
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Ergocalciferol or Vitamin D2 or Calciferol Manufacturers, Suppliers, Exporters, Wholesalers:

Plot No. 2900/46&47 + 2900/163to167, GIDC, Ankleshwar, Dist. Bharuch, India
India, USA, UAE
TEL: (Office) 91-22-23774610, 91-22-23723564

If I give you “My Word” Nobody can undo it.
If I sign an “Agreement” my Lawyer will undo it

Our products are for industrial and laboratory use only. The user must test the material before use. We are not dispensing chemists or druggist and do not offer over the counter type (OTC) products for medical use by individuals.

Specifications, Properties, Uses, Ergocalciferol or Vitamin D2 or Calciferol USP BP Ph Eur FCC Food Grade Manufacturer Supplier Exporter Wholesale & Small Packs, CAS Number 50-14-6.

Ergocalciferol or Vitamin D2 or Calciferol Manufacturers, Suppliers, Exporters, Wholesalers: