Specifications, Uses, SDS of Citric Acid Manufacturers

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Specifications, Properties, Uses, SDS of Citric Acid Monohydrate Anhydrous USP BP Ph Eur Analytical Reagent FCC Food Grade Manufacturer Supplier Exporter Wholesale & Small Packs, CAS Number 5949-29-1 & 77-92-9.
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Muby Chem Pvt. Ltd. is a several decades old group of companies, engaged in manufacturing, supplying, distributing, wholesale supplies of Citric Acid Monohydrate Anhydrous for actual users, including retail or small pack supplies for research and development work.

We supply fine and speciality chemicals, pharmaceutical excipients, mineral fortifiers in chemically pure, analytical reagent grade, IP BP USP Ph Eur EP JP and other pharmaceutical grade monograph including FCC Food grade chemicals and Nutraceuticals at best prices. We and/or our associated units have all the facilities to supply as per cGMP standard observing good manufacturing practice and good laboratory practice. We can assure low microbial count and also offer a test certificate for the same. We maintain warehouses across USA, India, and UAE. Our group exports to USA, Canada, Mexico, Argentina, Brazil, Chile, Korea, Malaysia, Thailand, Indonesia, Europe, and several other parts of the world. We supply in wholesale container loads to small pack of few grams. Solid products may be specified for it size and shape as desired by the buyer.

The Properties, Specifications, Monograph and Uses of Citric Acid Monohydrate Anhydrous :

Citric Acid Monohydrate CAS Number 5949-29-1, EINECS EC number 201-069-1, HS Code: 29181400, Molecular Weight 210.14, Chemical Formula C6H8O7.H2O
Citric Acid Anhydrous CAS Number 77-92-9, EINECS EC number 201-069-1, HS Code: 29181400, Molecular Weight 192.13, Chemical Formula C6H8O7

Citric acid is an organic compound with the chemical formula HOC(CO2H)(CH2CO2H)2. Usually encountered as a white solid, it is a weak organic acid. It occurs naturally in citrus fruits. Because it is one of the stronger edible acids, the dominant use of citric acid is as a flavoring and preservative in food and beverages, especially soft drinks and candies. Within the European Union it is denoted by E number E330. Citric acid can be added to ice cream as an emulsifying agent to keep fats from separating, to caramel to prevent sucrose crystallization, or in recipes in place of fresh lemon juice. Citric acid is an excellent chelating agent, binding metals by making them soluble. It is used to remove and discourage the buildup of limescale from boilers and evaporators. Citric acid is used as an acidulant in creams, gels, and liquids. The buffering properties of citrates are used to control pH in household cleaners and pharmaceuticals.

Anhydrous Citric Acid USP Grade Specifications:
C6H8O7 --- 192.1
1,2,3-Propanetricarboxylic acid, 2-hydroxy-;
Citric acid CAS 77-92-9

DEFINITION
Anhydrous Citric Acid contains NLT 99.5% and NMT 100.5% of C6H8O7, calculated on the anhydrous basis.

IDENTIFICATION
A. Infrared Absorption: Dry the substance to be examined at 105C for 2 h.

ASSAY
Procedure
Sample: 0.550 g of Anhydrous Citric Acid; record weight accurately.
Analysis: Dissolve the Sample in 50 mL of water. Add 0.5 mL of phenolphthalein TS. Titrate with 1 N sodium hydroxide VS. Each mL of 1 N sodium hydroxide is equivalent to 64.03 mg of C6H8O7.
Acceptance criteria: 99.5% to 100.5% on the anhydrous basis.

Residue on Ignition: NMT 0.1%, determined on 1.0 g
Sulfate: To pass the test. --- (0.015%).
Limit of Aluminum (where it is labeled as intended for use in dialysis): To pass the test. --- (0.2 ppm).
Limit of Oxalic Acid: To pass the test.
Bacterial Endotoxins Test: The level of bacterial endotoxins is such that the requirement in the relevant dosage form monograph(s) in which Anhydrous Citric Acid is used can be met. Where the label states that Anhydrous& Citric Acid must be subjected to further processing during the preparation of injectable dosage forms, the level of bacterial endotoxins is such that the requirement in the relevant dosage form monograph(s) in which Anhydrous Citric Acid is used can be met.
Clarity of Solution: To pass the test.
Color of Solution: To pass the test.
Readily Carbonizable Substances:
Sample: 1.0 g of powdered Anhydrous Citric Acid
Analysis: Transfer the Sample to a 22-mm x 175-mm test tube previously rinsed with 10 mL of sulfuric acid and allowed to drain for 10 min. Add 10 mL of sulfuric acid, agitate until solution is complete, and immerse in a water bath at 90±1C for 60±0.5 min, keeping the level of the acid below the level of the water during the entire period. Cool the tube in running water and transfer the acid to a color-comparison tube.
Acceptance criteria: The color of the acid is not darker than that of a similar volume of Matching Fluid K in a matching tube, the tubes being observed vertically against a white background.
Sterility Tests: Where the label states that Anhydrous Citric Acid is sterile, it meets the requirements for Sterility Tests in the relevant dosage form monograph(s) in which Anhydrous Citric Acid is used.
Water Determination:
Sample: 2.0 g of Anhydrous Citric Acid
Acceptance criteria: NMT 1.0%
Packaging and Storage: Preserve in tight containers. No storage requirements specified.

Citric Acid Monohydrate USP Grade Specifications:
C6H8O7-H2O --- 210.14
1,2,3-Propanetricarboxylic acid, 2-hydroxy-, monohydrate CAS 5949-29-1

DEFINITION
Citric Acid Monohydrate contains one molecule of water of hydration. It contains NLT 99.5% and NMT 100.5% of C6H8O7, calculated on the anhydrous basis.

IDENTIFICATION
A. Infrared Absorption: Dry the substance to be examined at 105C for 2 h.

ASSAY
Procedure
Sample: 0.550 g of Citric Acid Monohydrate. Record the weight accurately.
Analysis: Dissolve the Sample in 50 mL of water and add 0.5 mL of phenolphthalein. Titrate with 1 N sodium hydroxide. Each mL of 1 N sodium hydroxide is equivalent to 64.03 mg of C6H8O7.
Acceptance criteria: 99.5% to 100.5% on the anhydrous basis.

Specifications of Citric Acid Monohydrate BP Ph Eur Grade
C6H8O7-H2O -- 210 -- CAS 5949-29-1
Citric Acid BP Monohydrate

DEFINITION
2-Hydroxypropane-1,2,3-tricarboxylic acid monohydrate.
Content: 99.5 per cent to 100.5 per cent (anhydrous substance).

CHARACTERS
Appearance: White or almost white, crystalline powder, colourless crystals or granules, efflorescent.
Solubility: Very soluble in water, freely soluble in ethanol (96 per cent).

IDENTIFICATION
First identification B, E.
Second identification A, C, D, E.
A. Dissolve 1 g in 10 ml of water. The solution is strongly acidic.
B. Infrared absorption spectrophotometry.
C. Add about 5 mg to a mixture of 1 ml of acetic anhydride and 3 ml of pyridine. A red colour develops.
D. Dissolve 0.5 g in 5 ml of water, neutralize using 1 M sodium hydroxide (about 7 ml), add 10 ml of calcium chloride solution R and heat to boiling. A white precipitate is formed.
E. Water (see Tests).

TESTS
Appearance of solution: The solution is clear and not more intensely coloured than reference.
Dissolve 2.0 g in water and dilute to 10 ml with the same solvent.
Readily carbonizable substances: To 1.0 g in a cleaned test tube add 10 ml of sulphuric acid and immediately heat the mixture in a water-bath at 90±1C for 60 min. Cool rapidly immediately afterwards. The solution is not more intensely coloured than a mixture of 1 ml of red primary solution and 9 ml of yellow primary solution.
Oxalic acid: Maximum 360 ppm, calculated as anhydrous oxalic acid.
Sulphates: Maximum 150 ppm.
Aluminium: Maximum 0.2 ppm, if intended for use in the manufacture of dialysis solutions.
Heavy metals: Maximum 10 ppm.
Water: 7.5 per cent to 9.0 per cent, determined on 0.500 g.
Sulphated ash: Maximum 0.1 per cent, determined on 1.0 g.
Bacterial endotoxins: Less than 0.5 IU/mg, if intended for use in the manufacture of parenteral dosage forms without a further appropriate procedure for the removal of bacterial endotoxins.

Specifications of Citric Acid FCC Food Grade
C6H8O7 Formula wt, anhydrous 192.13
C6H8O7-H2O Formula wt, monohydrate 210.14
INS: 330 CAS: anhydrous 77-92-9
CAS: monohydrate 5949-29-1

DESCRIPTION
Citric Acid occurs as colorless, translucent crystals or as a white, granular to fine, crystalline powder. It is anhydrous or contains one molecule of water of hydration. The hydrous form is efflorescent in dry air. It is odorless and has a strongly acid taste. One gram is soluble in about 0.5 mL of water, in about 2 mL of alcohol, and in about 30 mL of ether.
Function: Sequestrant; dispersing agent; acidifier; flavoring agent.

REQUIREMENTS
Labeling: Indicate whether it is anhydrous or hydrous.
Identification: A 1:10 aqueous solution gives positive tests for Citrate.
Assay: Not less than 99.5% and not more than 100.5% of C6H8O7, calculated on the anhydrous basis.
Lead: Not more than 0.5 mg/kg.
Oxalate: Passes test.
Readily Carbonizable: Substances Passes test.
Residue on Ignition: Not more than 0.05%.
Tridodecylamine (for solvent-extracted Citric Acid only): Not more than 0.1 mg/kg.
Water: Anhydrous: Not more than 0.5%; Monohydrate: Not more than 8.8%.

Specifications of Citric Acid Analytical Reagent
Citric Acid, Anhydrous, and Citric Acid, Monohydrate
2-Hydroxy-1,2,3-propanetricarboxylic Acid
HOCOCH2C(OH)(COOH)CH2COOH; Formula Wt. 192.13
HOCOCH2C(OH)(COOH)CH2COOH-H2O; Formula Wt. 210.14
CAS Number 77-92-9 (Anhydrous); 5949-29-1 (Monohydrate)

MAXIMUM ALLOWABLE
Insoluble matter: 0.005%
Residue after ignition: 0.02%
Chloride (Cl): 0.001%
Oxalate (C2O4): Passes test
Phosphate (PO4): 0.001%
Sulfate (SO4): 0.002%
Iron (Fe): 3 ppm
Lead (Pb): 2 ppm
Substances carbonizable by hot sulfuric acid: Passes test.

We also manufacture Micro-Encapsulated Citric Acid, having core of Citric Acid and coating of vegetable oil or mono and diglycerides or as desired by the buyer. Encapsulation will make it slow release or extended release.

Product Name & Other Names: Citric Acid or 2-Hydroxy-1,2,3-propanetricarboxylic acid
CAS#: 77-92-9 for anhydrous and 5949-29-1 for monohydrate.
EINECS EC Number: 201-069-1
Molecular Weight: 192.13 for anhydrous and 210.14 for monohydrate.
Chemical Formula: C6H8O7 for anhydrous and C6H8O7-H2O for monohydrate.
Relevant uses and uses advised against (if any): Industrial, Laboratory and Fracturing use.
Supplier: As per letterhead.

GHS, Globally Harmonized System Classification in accordance with 29 CFR 1910
Classification according to Regulation (EC) No 1272/2008

Acute toxicity, Dermal (Category 5)
Skin irritation (Category 3)
Eye irritation (Category 2A)

Hazard statements:
H313: May be harmful in contact with skin.
H316: Causes mild skin irritation
H319: Causes serious eye irritation

Precautionary statements:
P262: Do not get in eyes, on skin, or on clothing.
P264: Wash skin thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P270: Do not eat, drink or smoke when using this product.
P273: Avoid release to the environment.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
P332+313: If skin irritation occurs: Get medical advice/attention.
P302+ P352 - IF ON SKIN: Wash with plenty of soap and water.
P305+ P351 + P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+P313 If eye irritation persists: Get medical advice/ attention.

Product Name & Other Names: Citric Acid or 2-Hydroxy-1,2,3-propanetricarboxylic acid
CAS#: 77-92-9 for anhydrous and 5949-29-1 for monohydrate.
EINECS EC Number: 201-069-1

Eyes: Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid. Do NOT allow victim to rub or keep eyes closed.
Skin: Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes. Get medical aid if irritation develops or persists. Wash clothing before reuse.
Ingestion: Do NOT induce vomiting. If victim is conscious and alert, give 2-4 cupful of milk or water. Never give anything by mouth to an unconscious person. Get medical aid.
Inhalation: Remove from exposure to fresh air immediately. If breathing is difficult, give oxygen. Get medical aid. Do NOT use mouth-to-mouth resuscitation. If breathing has ceased apply artificial respiration using oxygen and a suitable mechanical device such as a bag and a mask.
Notes to Physician: Treat symptomatically and supportively.

General Information: As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion.
Extinguishing Media: Use water spray, dry chemical, carbon dioxide, or chemical foam. Use agent most appropriate to extinguish fire. Do NOT get water inside containers.
Suitable extinguishing media: Water, Foam, Carbon dioxide (CO2), Dry powder. No limitation of extinguishing media is specified.
Extinguishing Media Not recommended: Avoid using solid water jet as it may scatter the fire.
Special Information: In the event of a fire, wear full protective clothing and NIOSH-approved self-contained breathing apparatus with full face piece operated in the pressure demand or other positive pressure mode. At high temperatures under fire conditions, it may produce toxic or irritating fumes. Fire-extinguishing work is done from the windward and the suitable fire-extinguishing method according to the surrounding situation is used. Uninvolved persons should evacuate to a safe place.

Personal precautions, protective equipment, and emergency procedures: Ventilate area of leak or spill. Avoid breathing dust/fumes/gas/mist/vapors/spray. Use individual protective equipment (waterproof boots, suitable protective clothing, safety glasses, etc.). Restrict unprotected personnel from the area. Prevent any contact with hot surfaces. Do not approach facing the wind. Do not touch the spilled material.
Environmental precautions: Do not let the product enter drains, soil, or water sources.
Methods and materials used for containment Cleanup procedures and Storage: Contain spilled material. Cover with an inert, non-combustible absorbent material, (e.g. sand, earth, diatomaceous earth, vermiculite). Vacuum or sweep-up and remove to an approved disposal container. Finish cleaning by spreading water on the contaminated surface and allow to evacuate as per law. Eliminate all ignition sources. Spill of Citric acid may be neutralized with lime.

Precautions for safe handling: Apply according to good manufacturing and industrial hygiene practices. Ensure proper ventilation. In case of insufficient ventilation, wear suitable respiratory equipment. Wash thoroughly after handling. Do not drink, eat, or smoke while handling. Avoid contact with skin, eyes, and clothing. Minimize dust generation. Avoid breathing dust/fumes/gas/mist/vapors/spray. Avoid contact with eyes, skin, and clothing. Keep container tightly closed. Avoid ingestion and inhalation. Use individual protective equipment (waterproof boots, suitable protective clothing, safety glasses, etc.). Prevent any contact with hot surfaces.
Conditions for safe storage, including any incompatibilities: Store in cool, dry, and ventilated area away from heat sources and protected from sunlight in tightly closed original container. Keep air contact to a minimum. Store protected from heat, sparks and ignition sources and incompatible materials. Avoid contact with skin and eyes. Avoid inhalation of dust/mist/vapor. Do not store with incompatible materials like strong oxidizing agents, sulfides, metal nitrates, alkali carbonates, alkalis, potassium tartrate, acetates, bicarbonates. Store protected from moisture.

Airborne Exposure Limits: None established.
Ventilation System: A system of local and/or general exhaust is recommended to keep employee exposures as low as possible. Local exhaust ventilation is generally preferred because it can control the emissions of the contaminant at its source, preventing dispersion of it into the general work area. Please refer to the ACGIH document, Industrial Ventilation, A Manual of Recommended Practices, most recent edition, for details.
Personal Respirators (NIOSH Approved): For conditions of use where exposure to dust or mist is apparent and engineering controls are not feasible, a particulate respirator (NIOSH type N95 or better filters) may be worn. If oil particles (e.g. lubricants, cutting fluids, glycerin, etc.) are present, use a NIOSH type R or P filter. For emergencies or instances where the exposure levels are not known, use a full-face positive-pressure, air-supplied respirator. WARNING: Air-purifying respirators do not protect workers in oxygen-deficient atmospheres.
Skin Protection: Wear impervious protective clothing, including boots, gloves, lab coat, apron or coveralls, as appropriate, to prevent skin contact.
Eye Protection: Use chemical safety goggles and/or full face shield where dusting or splashing of solutions is possible. Maintain eye wash fountain and quick-drench facilities in work area of Citric acid.
Other Control Measures: Maintain good housekeeping in work area. Dust deposits on floors and other surfaces may pick up moisture and cause the surfaces to become slippery and present safety hazards. Handle in accordance with good industrial hygiene and safety practice. Wash hands after handling.

Appearance: White crystals, granules or powder.
Odor: Odorless.
Odor threshold: Not available.
pH: 2.2 (0.1 N sol)
Relative density: around 1.54
Melting Point: ca. 100C (ca. 212F).
Initial boiling point and boiling range: Not available.
Flash point: Not available.
Auto-ignition temperature: Not available.
Decomposition temperature: Not available.
Upper/lower flammability or explosive limits: Not available.
Vapor pressure: Not available.
Vapor density: Not available.
Evaporation rate: Not available.
Flammability (solid, gas): Not available.
Partition coefficient: n-octanol/water: Not available.
Solubility: ca. 60 g/100 ml @ 20C (Anhydrous)
Viscosity: Not available.
Molecular Weight: 192.13 for anhydrous and 210.14 for monohydrate.
Chemical Formula: C6H8O7 for anhydrous and C6H8O7-H2O for monohydrate.

Chemical Stability: Stable under normal temperatures and pressures.
Conditions to Avoid: Incompatible materials, dust generation, moisture, exposure to moist air or water.
Incompatibilities with Other Materials: Oxidizing agents, sulfides (inorganic, e.g. ferric sulfide, lead sulfide, sodium sulfide), metal nitrates, alkali carbonates, alkalis, potassium tartrate, acetates, bicarbonates.
Hazardous Decomposition Products: Carbon monoxide, irritating and toxic fumes and gases, carbon dioxide.
Hazardous Polymerization: Will not occur.

Oral rat LD50: 3 gm/kg; Irritation skin rabbit: 500 mg/24H mild; Eye rabbit: 750 µg/24H severe.
Carcinogenicity: No component of this product present at levels greater than or equal to 0.1% is identified as probable, possible or confirmed human carcinogen by IARC, ACGIH, OSHA and NTP.
Mutagenic Effects: Not available.
Teratogenic Effects: Not available.
Developmental Toxicity: Not available.
Reproductive Effects: No information available.

Toxicity to fish LC50 Leuciscus idus (Golden orfe): 440 - 760 mg/l; 96 h.
Toxicity to daphnia and other aquatic invertebrates: EC50 Daphnia magna (Water flea): ca. 120 mg/l; 72 h.
Persistence and Degradability: It is water soluble and unlikely to persist.
Mobility: It is water soluble and mobile.
Bioaccumulation/ Accumulation: Will not bioaccumulate.
Results of PBT and vPvB assessment: No data available for assessment.

Whatever cannot be saved for recovery or recycling should be managed in an appropriate and approved waste disposal facility. Processing use or contamination of this product may change the waste management options. State and local disposal regulations may differ from federal disposal regulations. Dispose of container of Citric acid and unused contents in accordance with local requirements.

Land Transport DOT USA, TDG Canada & ADR/RID Europe: Not dangerous goods.
Sea Transport IMO/IMDG: Not dangerous goods.
Air Transport ICAO/IATA: Not dangerous goods.

USA:
California Proposition 65: Not listed.
SARA 311/312: Immediate health hazard. See section 2.

Citric Acid Monohydrate Anhydrous Manufacturers, Suppliers, Exporters, Wholesalers:

Plot No. 2900/46&47 + 2900/163to167, GIDC, Ankleshwar, Dist. Bharuch, India
India, USA, UAE
TEL: (Office) 91-22-23774610, 91-22-23723564

If I give you “My Word” Nobody can undo it.
If I sign an “Agreement” my Lawyer will undo it

Our products are for industrial and laboratory use only. The user must test the material before use. We are not dispensing chemists or druggist and do not offer over the counter type (OTC) products for medical use by individuals. Check.

Specifications, Properties, Uses, SDS of Citric Acid Monohydrate Anhydrous USP BP Ph Eur Analytical Reagent FCC Food Grade Manufacturer Supplier Exporter Wholesale & Small Packs, CAS Number 5949-29-1 & 77-92-9.

Citric Acid Monohydrate Anhydrous Manufacturers, Suppliers, Exporters, Wholesalers: