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King of Chemicals Manufacturers Pyridostigmine Bromide and API BP Ph Eur EP USP NF IP JP ChP PPRC Reagent FCC Food Grade Manufacturer |
Specifications, Properties, Uses, SDS of Pyridostigmine Bromide API BP Ph Eur USP Grade Manufacturer Supplier Exporter Wholesale & Small Packs, CAS Number 101-26-8. | |
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Muby Chem Pvt. Ltd. is a several decades old group of companies, engaged in manufacturing, supplying, distributing, wholesale supplies of Pyridostigmine Bromide BP Ph Eur USP Grade for actual users, including retail or small pack supplies for research and development work.
We supply fine and speciality chemicals, pharmaceutical excipients, mineral fortifiers in chemically pure, analytical reagent grade, API IP BP USP Ph Eur EP JP ChP PPRC and other pharmaceutical grade monograph including FCC Food grade chemicals and Nutraceuticals at best prices. We and/or our associated units have all the facilities to supply as per cGMP standard observing good manufacturing practice and good laboratory practice. We can assure low microbial count and also offer a test certificate for the same. We maintain warehouses across USA, India, and UAE. Our group exports to USA, Canada, Mexico, Argentina, Brazil, Chile, Korea, Malaysia, Thailand, Indonesia, Europe, and several other parts of the world. We supply in wholesale container loads to small pack of few grams. Solid products may be specified for it size and shape as desired by the buyer.
Pyridostigmine Bromide CAS Number 101-26-8
For Properties Specifications Uses of Pyridostigmine Bromide Click Properties, Specifications, Uses, Price, Process of Pyridostigmine Bromide Manufacturer.
For For SDS MSDS Sheet of Pyridostigmine Bromide Click SDS Safety Data Sheet MSDS Sheet of Pyridostigmine Bromide Manufacturer.
The Properties, Specifications, Monograph and Uses of Pyridostigmine Bromide:
Pyridostigmine bromide is a prescription medication primarily used to improve muscle strength and treat myasthenia gravis. It is used in medecine for Myasthenia gravis, Reversal of muscle relaxants, Nerve agent pretreatment, Post-operative urinary retention, Paralytic ileus and severe constipation, Congenital myasthenic syndromes, Postural orthostatic tachycardia syndrome and orthostatic hypotension, etc.
Pyridostigmine Bromide BP Ph Eur Grade Specifications:
C9H13BrN2O2 --- 261.1 CAS 101-26-8
Action and use: Cholinesterase inhibitor.
DEFINITION
3-[(Dimethylcarbamoyl)oxy]-1-methylpyridinium bromide.
Content: 98.5 per cent to 101.0 per cent (dried substance).
CHARACTERS
Appearance: White or almost white, crystalline, deliquescent powder.
Solubility: Very soluble in water and in ethanol (96 per cent).
IDENTIFICATION
A. Infrared absorption spectrophotometry.
B. It gives reaction of bromides.
TESTS
Solution S: Dissolve 1.0 g in carbon dioxide-free water and dilute to 100 mL with the same solvent.
Appearance of solution: Solution S is clear and colourless.
Acidity or alkalinity: To 40 mL of solution S add a few drops of methyl red solution. To 20 mL of this solution add 0.2 mL of0.02 M sodium hydroxide. The solution is yellow. To the other 20 mL add 0.2 mL of 0.02 M hydrochloric acid. The solution is red.
Related substances: To pass the test by Liquid chromatography.
Sulfated ash: Maximum 0.1 per cent, determined on 1.0 g.
Storage: In an airtight container, protected from light. If the substance is sterile, store in a sterile, air-tight, tamper-proof container, protected from light.
Pyridostigmine Bromide USP Grade Specifications:
C9H13BrN2O2 --- 261.12
Pyridinium, 3-[[(dimethylamino)carbonyl]oxy]-1-methyl-, bromide.
3-Hydroxy-1-methylpyridinium bromide dimethylcarbamate
CAS 101-26-8
UNII: KVI301NA53
UNII: 19QM69HH21
Pyridostigmine Bromide contains not less than 98.5 percent and not more than 100.5 percent of C9H13BrN2O2, calculated on the dried basis.
Packaging and storage: Preserve in tight containers.
Identification:
A: Infrared Absorption.
B: Ultraviolet Absorption.
C: To about 100 mg in a test tube add 0.6 mL of 1 N sodium hydroxide: an orange color develops. When the mixture is heated, the color changes to yellow, and a strip of moistened red litmus paper held over the top of the test tube turns blue.
D: A solution (1 in 50) responds to tests for Bromide.
Melting range: between 154C and 157C, the test specimen having been previously dried.
Loss on drying: Dry it in a suitable vacuum drying tube, using phosphorus pentoxide as the desiccant, at 100C for 4 hours: it loses not more than 2.0% of its weight.
Residue on ignition: not more than 0.1%.
Ordinary impurities: To pass the test.
The MSDS-SDS Hazard Statement of Pyridostigmine Bromide:
Pyridostigmine Bromide SDS GHS, Safety Data Sheet
MSDS Sheet, Material Safety Data Sheet
1. Product Identification
Product Name & Other Names: Pyridostigmine Bromide.
CAS No.: 101-26-8
EINECS EC No.: 202-929-9
Molecular Formula: C9H13BrN2O2
Molecular Weight: 261.12
Relevant uses and uses advised against (if any): Industrial Manufacturing.
Suppliers: As per letterhead.
2. Hazards Identification
GHS, Globally Harmonized System Classification in accordance with 29 CFR 1910
Hazard Class and Category Code(s), Regulation (EC) No 1272/2008 (CLP):
Acute toxicity, Oral (Category 2), H300
Acute toxicity, Inhalation (Category 2), H330
Acute toxicity, Dermal (Category 1), H310
Skin sensitization, (Category 1), H317
Labeling according to Regulation (EC) No 1272/2008
GHS Label Elements Toxic |
GHS Label Elements Health Hazard |
Signal Words: Danger
Hazard statements:
H300: Fatal if swallowed.
H310: Fatal in contact with skin.
H330: Fatal if inhaled.
H317 May cause an allergic skin reaction.
Precautionary statements:
P261: Avoid breathing dust/fume/gas/mist/vapors/spray.
P262 Do not get in eyes, on skin, or on clothing.
P264: Wash … thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P271: Use only outdoors or in a well-ventilated area.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
P330: Rinse mouth.
P304+340+310: IF INHALED: Remove person to fresh air and keep comfortable for breathing. Immediately call a POISON CENTER/doctor.
P305+351+338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do – continue rinsing.
3. Composition/Information on Ingredients
Product Name & Other Names: Pyridostigmine Bromide.
CAS No.: 101-26-8
EINECS EC No.: 202-929-9
4. First Aid Measures
Always seek medical attention after first aid measures are provided.
Inhalation: Remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical attention.
Ingestion: Never give anything by mouth to an unconscious person. Get medical attention.
Skin Contact: Wipe off excess material from skin then immediately flush skin with plenty of water for at least 15 minutes. Remove contaminated clothing and shoes. Get medical attention. Wash clothing before reusing. Thoroughly clean shoes before reusing them. Get medical attention.
Eye Contact: Immediately flush eyes with plenty of water for at least 15 minutes, lifting lower and upper eyelids occasionally. Get medical attention immediately.
5. Fire Fighting Measures
Products of Combustion: Carbon dioxide, Carbon monoxide, Nitrogen oxide, Bromine, and fumes.
Explosion: May be explosive in presence of heat.
Fire Extinguishing Media: Use dry powder or dry sand should be preferred. Do not use solid water stream. Flammable liquid and vapor. For small (incipient) fires, use, media such as "alcohol" foam, dry chemical, or carbon dioxide. For large fires, apply water from as far as possible. Use large quantities (flooding) of water applied as mist or spray. Vapors are heavier than air and may travel to a source of ignition and flashback. Vapors can spread along the ground and collect in low or confined areas. Never direct a water jet in the container to prevent any splashing of the product which could cause spreading of the fire. Cool containing vessels with water jet to prevent pressure build-up, auto-ignition, or explosion.
Special Information: In the event of a fire, wear full protective clothing and NIOSH-approved self-contained breathing apparatus with full face piece operated in the pressure demand or other positive pressure mode. At high temperatures under fire conditions, it may produce toxic or irritating fumes.
6. Accidental Release Measures
Personal precautions, protective equipment, and emergency procedures: Avoid breathing dust/fumes/gas/mist/vapors/spray. Use individual protective equipment (waterproof boots, suitable protective clothing, safety glasses, etc.). Restrict unprotected personnel from the area. Prevent any contact with hot surfaces. Do not approach facing the wind. Do not touch the spilled material.
Environmental precautions: Do not let the product enter drains, soil, or water sources.
Methods and materials used for containment cleanup procedures and Storage: Remove all sources of ignition. Provide proper ventilation. Keep people away from upwind of spill/leak. Entry to non-involved personnel should be controlled around the leakage area by roping off. Absorb the material on a porous, inert material such as earth, sand, or vermiculite. Carefully sweep up the material without causing dust. Dispose it of in accordance with local regulations.
Large spillages should be contained by use of sand or another inert material. The spillage should be transferred to a suitable container and recovered or disposed of in accordance with local regulations. Because of the danger of spontaneous combustion, any combustible material, such as cloth, used for cleaning spillages, should be saturated with water, and disposed of promptly, preferably by incineration.
7. Handling and Storage
Precautions for safe handling: Apply according to good manufacturing and industrial hygiene practices. Ensure proper ventilation. Wash thoroughly after handling it. Do not drink, eat, or smoke while handling. Avoid contact with skin, eyes, and clothing. Minimize dust generation. Avoid breathing dust/fumes/gas/mist/vapors/spray. Keep container tightly closed. Avoid ingestion and inhalation. Use individual protective equipment (waterproof boots, suitable protective clothing, safety glasses, etc.). Wear suitable protective clothing. In case of insufficient ventilation, wear suitable respiratory equipment. Keep away from heat/sparks/open flame/hot surfaces.
Conditions for safe storage, including any incompatibilities: Store in cool, dry, and ventilated area away from heat sources and protected from sunlight in tightly closed original containers. Keep air contact to a minimum. Do not leave the material container open. Store protected from light, heat, sparks and ignition sources and incompatible materials. Avoid inhalation of dust/mist/vapor. Do not store with incompatible materials like oxidizing agents, acids, bases, reducing agents. Store locked up. Storage: In an airtight container, protected from light. If the substance is sterile, store in a sterile, air-tight, tamper-proof container, protected from light.
8. Exposure Controls/Personal Protection
Airborne Exposure Limits: Not Established by regulating bodies.
Ventilation System: A system of local and/or general exhaust is recommended to keep employee exposure as low as possible.
Personal Respirators (NIOSH Approved): For conditions of use where exposure to dust or mist is apparent and engineering controls are not feasible, a particulate respirator may be worn.
Skin Protection: Wear protective gloves and clean body-covering clothing.
Eye Protection: Use chemical safety goggles and/or full-face shield where dusting or splashing of solutions is possible. Maintain eye wash fountain and quick-drench facilities in work area.
Other Control Measures: Maintain good housekeeping in work area. Handle in accordance with good industrial hygiene and safety practice. Wash hands after handling.
9. Physical and Chemical Properties
Appearance: White or almost white, crystalline, deliquescent powder.
Odor: No data found.
Odor threshold: No data found.
pH: No data found.
Relative density: No data found.
Boiling Point: No data found.
Melting Point: 154C to 157C literature.
Flash Point: No data found.
Auto-ignition temperature: No data found.
Decomposition temperature: No data found.
Upper/lower flammability or explosive limits: No data found.
Vapor pressure: No data found.
Vapor density: No data found.
Evaporation rate: No data found.
Flammability (solid, gas): No data found.
Partition coefficient: n-octanol/water: No data found.
Viscosity: No data found.
Solubility: Freely soluble in water, alcohol. Insoluble in ether, acetone, benzene.
10. Stability and Reactivity
Stability: Stable under recommended conditions of use and storage. Vapour/air-mixtures are explosive at high temperature.
Hazardous Decomposition Products: It emits Carbon oxides, Nitrogen oxide, Bromine and Fumes.
Hazardous Polymerization: Will not occur.
Incompatibilities: Strong oxidizing agents, Acids, Bases, Reducing agents.
Conditions to Avoid: Incompatibles, oxidizing agents, heat flame & light.
11. Toxicological Information
Fatal if inhaled, swallowed and in skin contact.
LD50 Oral - Rat – 37500 µg/kg.
Carcinogenicity: Not listed by ACGIH, IARC, NTP, or CA Prop 65.
Epidemiology: No data found.
Teratogenicity: No data found.
Reproductive Effects: No data found.
Mutagenicity: No data found.
Neurotoxicity: No data found.
May cause sensitization by skin contact.
12. Ecological Information
Environmental Toxicity: No data found.
Environmental Fate: No data found.
Mobility: Will be mobile in the environment due to its water solubility.
Persistence and Degradability: Soluble in water Persistence is unlikely based on information available.
Toxicity of the Products of Biodegradation: No data found.
13. Disposal Considerations
Whatever cannot be saved for recovery, or recycling should be managed in an appropriate and approved waste disposal facility. Follow all the pollution control rules.
14. Transport Information
DOT USA, TDG Canada & ADR/RID Europe:
Shipping Name: Toxic solid, organic. (Pyridostigmine bromide).
Hazard Class: 6.1, Packing Group: II
UN Number: UN2811
IATA & IMDG/IMO:
Shipping Name: Toxic solid, organic. (Pyridostigmine bromide).
Hazard Class: 6.1(3), Packing Group: II
UN Number: UN2811
15. Regulatory Information
USA:
SARA 311/312 Hazards: See section 2.
California prop. 65: Not listed.
16. Other Information
Disclaimer:
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Our company provides this MSDS sheet in good faith but makes no representation as to its comprehensiveness or accuracy. This SDS sheet is intended only as a guide to the appropriate precautionary handling of the material by a properly trained person using this product. The above information has been compiled from various sources and has the possibility of discrepancy and being out-dated information. Individuals receiving the information must exercise their independent judgment and do further search in determining its appropriateness for a particular purpose. In no case shall our company be liable to loss or damages by the product user.
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Pyridostigmine Bromide Manufacturers, Suppliers, Exporters, Wholesalers:
King of Chemicals manufacturers
Plot No. 2900/46&47 + 2900/163to167, GIDC, Ankleshwar, Dist. Bharuch, India
India, USA, UAE
TEL: (Office) 91-22-65290111
email: info@kingofchemicals.com
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Our products are for industrial and laboratory use only. The user must test the material before use. We are not despensing chemists or druggist and do not offer over the counter type (OTC) products for medical use by individuals.
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