 |
King of Chemicals Manufacturers Diphenhydramine Hydrochloride or Diphenhydramine HCl and API BP Ph Eur EP USP NF IP JP ChP PPRC Reagent FCC Food Grade Manufacturer |
Specifications, Properties, Uses, SDS of Diphenhydramine Hydrochloride or Diphenhydramine HCl USP BP Ph Eur EP Grade Manufacturer Supplier Exporter Wholesale & Small Packs, CAS Number 147-24-0. | |
| King of Chemicals has several associated companies having accreditations like cGMP, GLP - FDA Approved Good Manufacturing Practice and Good Laboratory Practice of WHO standard, ISO-9001, ISO-14001, ISO/IEC 17025, ISO ISO-45000, HACCP, FSSC 220000, FSSAI, "REACH" Registered, Kosher & Halal Certified. e-CTD and DMF support can be made available if needed. We offer API USP NF BP Ph Eur EP IP JP ChP PPRC Analytical Reagent FCC Food Grade Chemicals & Nutraceuticals. | |
         | |
------ 
Muby Chem Pvt. Ltd. is a several decades old group of companies, engaged in manufacturing, supplying, distributing, wholesale supplies of Diphenhydramine Hydrochloride or Diphenhydramine HCl USP BP Ph Eur EP Grade for actual users, including retail or small pack supplies for research and development work.
We supply fine and speciality chemicals, pharmaceutical excipients, mineral fortifiers in chemically pure, analytical reagent grade, API IP BP USP Ph Eur EP JP ChP PPRC and other pharmaceutical grade monograph including FCC Food grade chemicals and Nutraceuticals at best prices. We and/or our associated units have all the facilities to supply as per cGMP standard observing good manufacturing practice and good laboratory practice. We can assure low microbial count and also offer a test certificate for the same. We maintain warehouses across USA, India, and UAE. Our group exports to USA, Canada, Mexico, Argentina, Brazil, Chile, Korea, Malaysia, Thailand, Indonesia, Europe, and several other parts of the world. We supply in wholesale container loads to small pack of few grams. Solid products may be specified for it size and shape as desired by the buyer.
Diphenhydramine Hydrochloride or Diphenhydramine HCl CAS Number 147-24-0
For Properties Specifications Uses of Diphenhydramine Hydrochloride or Diphenhydramine HCl Click Properties, Specifications, Uses, Price, Process of Diphenhydramine Hydrochloride or Diphenhydramine HCl Manufacturer.
For For SDS MSDS Sheet of Diphenhydramine Hydrochloride or Diphenhydramine HCl Click SDS Safety Data Sheet MSDS Sheet of Diphenhydramine Hydrochloride or Diphenhydramine HCl Manufacturer.
The Properties, Specifications, Monograph and Uses of Diphenhydramine Hydrochloride or Diphenhydramine HCl:
Diphenhydramine Hydrochloride or Diphenhydramine HCl is a first-generation antihistamine widely used to treat allergic reactions, relieve common cold symptoms, manage motion sickness, and serve as a short-term sleep aid. Its use in medecine are for Allergy and Cold Symptom Relief, Management of Motion Sickness, Short-Term Sleep Aid, Early-Stage Parkinson’s Disease, Topical Itch Relief etc.
Diphenhydramine Hydrochloride BP Ph Eur Grade Specifications:
C17H22ClNO --- 291.8 CAS 147-24-0
Action and use: Histamine H1 receptor antagonist; antihistamine.
Preparations:
Diphenhydramine Oral Solution
Diphenhydramine Tablets.
DEFINITION
2-(Diphenylmethoxy)-N,N-dimethylethanamine hydrochloride.
Content: 99.0 per cent to 101.0 per cent (dried substance).
CHARACTERS
Appearance: White or almost white, crystalline powder.
Solubility: Very soluble in water, freely soluble in ethanol (96 per cent).
IDENTIFICATION
First identification: C, D
Second identification: A, B, D
A. Melting point: 168C to 172C.
B. Ultraviolet and visible absorption spectrophotometry
C. Infrared absorption spectrophotometry.
D. It gives reaction of chlorides.
Solution S: Dissolve 1.0 g in carbon dioxide-free water and dilute to 20 mL with the same solvent.
Appearance of solution: Solution S and a fivefold dilution of solution S are clear. Solution S is not more intensely coloured than reference solution.
Acidity or alkalinity: To 10 mL of solution S add 0.15 mL of methyl red solution and 0.25 mL of 0.01 M hydrochloric acid. The solution is pink. Not more than 0.5 mL of 0.01 M sodium hydroxide is required to change the colour of the indicator to yellow.
Related substances: To pass the test by Liquid chromatography.
Loss on drying: Maximum 0.5 per cent, determined on 1.000 g by drying in an oven at 105C.
Sulfated ash: Maximum 0.1 per cent, determined on 1.0 g.
Diphenhydramine Hydrochloride USP Grade Specifications:
C17H21NO-HCl --- 291.82
Ethanamine, 2-(diphenylmethoxy)-N,N-dimethyl-, hydrochloride;
2-(Diphenylmethoxy)-N,N-dimethylethylamine hydrochloride CAS 147-24-0
UNII: TC2D6JAD40
UNII: 8GTS82S83M
DEFINITION
Diphenhydramine Hydrochloride contains NLT 98.0% and NMT 102.0% of diphenhydramine hydrochloride (C17H21NO ·HCl), calculated on the dried basis.
IDENTIFICATION
A. Infrared Absorption
B. The retention time of the major peak of the Sample solution corresponds to that of the Standard solution, as obtained in the Assay.
C. Identification Tests—General, Chloride.
Residue on Ignition: NMT 0.1%
Organic Impurities: To pass the test by chromatography.
Acidity or Alkalinity:
Sample solution: 50 mg/mL of Diphenhydramine Hydrochloride in carbon ioxide-free water
Analysis: To 10 mL of the Sample solution, add 0.15 mL of methyl red TS 2 and 0.25 mL of 0.01 N hydrochloric acid. The solution is pink. Titrate with 0.01 N sodium hydroxide.
Acceptance criteria: ;NMT 0.5 mL of 0.01 N sodium hydroxide is required to change the color of the solution to yellow.
Loss on Drying: Dry a sample at 105C for 3 h. Loss NMT 0.5%
Packaging and Storage: Preserve in tight, light-resistant containers. Store at room temperature.
We also manufacture Diphenhydramine Hydrochloride as per EP Grade Monograph.
The MSDS-SDS Hazard Statement of Diphenhydramine Hydrochloride or Diphenhydramine HCl:
Diphenhydramine HCl or Diphenhydramine Hydrochloride
SDS, Safety Data Sheet
MSDS Sheet, Material Safety Data Sheet
1. Product Identification
Product Name/Synonyms: Diphenhydramine HCl or Diphenhydramine Hydrochloride
CAS No.:147-24-0
EINECS EC Number: 205-687-2
Molecular Weight: 291.82
Chemical Formula: C17H21NOClH
Relevant uses and uses advised against (if any): Industrial Manufacturing.
Suppliers: As per letterhead.
2. Hazards Identification
GHS, Globally Harmonized System Classification in accordance with 29 CFR 1910
Classification according to Regulation (EC) No 1272/2008
Acute toxicity, oral Category 4
Labeling according to Regulation (EC) No 1272/2008
GHS Label Elements Harmful |
Signal Words: Warning
Hazard statements:
H302: Harmful if swallowed.
Precautionary statements:
P262: Do not get in eyes, on skin, or on clothing.
P264: Wash skin thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P270: Do not eat, drink or smoke when using this product.
P362: Take off contaminated clothing and wash before reuse.
P301+312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell.
P332+313: If skin irritation occurs: Get medical advice/attention.
P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+P313 If eye irritation persists: Get medical advice/ attention.
3. Composition/Information on Ingredients
Product Name/Synonyms: Diphenhydramine HCl or Diphenhydramine Hydrochloride
CAS No.: 147-24-0
EINECS EC Number: 205-687-2
4. First Aid Measures
Inhalation: Remove to fresh air. Give oxygen if breathing is difficult; give artificial respiration if breathing has stopped. Keep a person warm and quiet; get medical attention.
Ingestion: Induce vomiting immediately if directed by medical personnel. Never give anything by mouth to an unconscious person.
Skin Contact: Immediately flush skin with plenty of soap and water for at least 15 minutes. Remove contaminated clothing and shoes. Wash clothing before reusing. Thoroughly clean shoes before reusing them. Get medical attention if irritation develops.
Eye Contact: Immediately flush eyes with plenty of water for at least 15 minutes, lifting upper and lower eyelids occasionally. Get medical attention.
Notes to Physician: Treat symptomatically.
5. Fire Fighting Measures
Fire: It is not considered to be a fire hazard. However, it will burn at high temperature.
Fire Extinguishing Media: Use water spray, alcohol-resistant foam, dry chemicals, or carbon dioxide. Use water spray to cool fire-exposed containers. Avoid solid water jet as it can scatter the fire.
Special hazards arising from the substance or mixture: Carbon oxides, Nitrogen oxides (NOx), Chlorine compounds and Fumes.
Special Information: In the event of a fire, wear full protective clothing and NIOSH-approved self-contained breathing apparatus with full face piece.
6. Accidental Release Measures
Personal precautions, protective equipment, and emergency procedures: Use personal protective equipment. Ventilate area of leak or spill. Avoid breathing dust/fumes/gas/mist/vapors/spray. Use individual protective equipment (waterproof boots, suitable protective clothing, safety glasses, etc.).
Environmental precautions: Do not let the product enter drains, soil, or water sources.
Methods and materials used for containment, cleanup procedures, and Storage: Contain spilled material. Pick up spills and place them in a suitable container for reclamation or disposal, using a method that does not generate dust.
7. Handling and Storage
Precautions for safe handling: Apply according to good manufacturing and industrial hygiene practices. Ensure proper ventilation. Wear personal protective equipment. Avoid ingestion and inhalation. Wash thoroughly after handling it. Do not drink, eat, or smoke while handling. Avoid contact with skin, eyes, and clothing. Minimize dust generation. Avoid breathing dust/fumes/gas/mist/vapors/spray. Keep the container tightly closed. Avoid ingestion and inhalation. Use individual protective equipment (waterproof boots, suitable protective clothing, safety glasses, etc.).
Conditions for safe storage, including any incompatibilities: Store in cool, dry, and ventilated area away from heat sources and protected from sunlight in tightly closed original containers. Keep air contact to a minimum. Do not leave the material container open. Store protected from heat, sparks and ignition sources and incompatible materials. Avoid inhalation of dust/mist/vapor. Do not store with incompatible materials like strong oxidizing agents. Avoid dust formation and control ignition sources. Storage: Room temperature. Short-term shipping may be ambient.
8. Exposure Controls/Personal Protection
Airborne Exposure Limits: None established by regulating bodies.
Ventilation System: In general, dilution ventilation is a satisfactory health hazard control for this substance. However, if conditions of use create discomfort for the worker, a local exhaust system should be considered.
Personal Respirators (NIOSH Approved): Not expected to require personal respirator usage. For conditions of use where exposure to dust or mist is apparent and engineering controls are not feasible, a particulate respirator (NIOSH type N95 or better filters) may be worn.
Skin Protection: Wear protective gloves and clean body-covering clothing.
Eye Protection: Use chemical safety goggles and/or full-face shield where dusting or splashing of solutions is possible. Maintain eye wash fountain and quick-drench facilities in work area.
9. Physical and Chemical Properties
Appearance: White or almost-white crystalline powder.
Odor: Odorless.
Odor threshold: Not applicable.
pH: No data found.
Relative density: No data found.
Boiling Point:No data found.
Melting Point: 168C to 172C literature.
Flash point: Not available.
Auto-ignition temperature: No data found.
Decomposition temperature: No data found.
Upper/lower flammability or explosive limits: No data found.
Vapor pressure: No data found.
Vapor density: No data found.
Evaporation rate: No data found.
Flammability (solid, gas): No data found.
Partition coefficient: n-octanol/water: No data found.
Solubility: Soluble in water. Soluble in Chloroform, Acetone, Alcohol.
Viscosity: No data found.
10. Stability and Reactivity
Stability: Stable under recommended conditions of use and storage.
Hazardous Decomposition Products: May produce oxides of nitrogen, carbon, chlorine compounds along with fumes when heated to decomposition.
Hazardous Polymerization: Will not occur.
Incompatibilities: Strong oxidizing agents.
Conditions to Avoid: Heat, flame, ignition sources, dusting, and incompatibles.
11. Toxicological Information
Toxicity Data: LD50 Oral - Rat - 500 mg/kg.
Carcinogenic Effects: Not a reported carcinogen by IARC, NTP, ACGIH, OSHA.
Mutagenic Effects: No data found.
Reproductive Effects: No data found.
Developmental Effects: No data found.
12. Ecological Information
Environmental Fate:No data found.
Persistence and degradability: Unlikely to persist.
Toxicity: No data found.
Bioaccumulative potential: No data found.
Mobility in soil: Likely to be mobile.
PBT and vPvB assessment: Not PBT or vPvB.
13. Disposal Considerations
Whatever cannot be saved for recovery, or recycling should be managed in an appropriate and approved waste disposal facility. Dispose of containers and unused material in accordance with legal requirements. Follow all the pollution control rules.
14. Transport Information
Land Transport DOT USA, TDG Canada & ADR/RID Europe: Not regulated.
Sea Transport IMDG/IMO: Not regulated.
Air Transport IATA/ICAO: Not regulated.
15. Regulatory Information
USA:
SARA 311/312 Hazardous Categorization: See section 2.
California Proposition 65: Not listed.
16. Other Information
Disclaimer:
**************************
Our company provides this MSDS sheet in good faith but makes no representation as to its comprehensiveness or accuracy. This SDS sheet is intended only as a guide to the appropriate precautionary handling of the material by a properly trained person using this product. The above information has been compiled from various sources and has the possibility of discrepancy and being out-dated information. Individuals receiving the information must exercise their independent judgment and do further search in determining its appropriateness for a particular purpose. In no case shall our company be liable to loss or damages by the product user.
**************************
Diphenhydramine Hydrochloride or Diphenhydramine HCl Manufacturers, Suppliers, Exporters, Wholesalers:
King of Chemicals manufacturers
Plot No. 2900/46&47 + 2900/163to167, GIDC, Ankleshwar, Dist. Bharuch, India
India, USA, UAE
TEL: (Office) 91-22-65290111
email: info@kingofchemicals.com
Copyright and Usual Disclaimer is Applicable --- November 2, 2026
If I give you “My Word” Nobody can undo it.
If I sign an “Agreement” my Lawyer will undo it
Our products are for industrial and laboratory use only. The user must test the material before use. We are not despensing chemists or druggist and do not offer over the counter type (OTC) products for medical use by individuals.
| We and our associates manufacture pure chemicals surpassing Monograph Specifications of Analytical Reagent Standards, British & European Pharmacopoeia BP Ph Eur EP Standard, US Pharmacopoeia USP NF Standard, Indian Pharmacopoeia IP Standard, Japan Pharmacopoeia JP Standard, FCC Food Grade Standard. | |
Diphenhydramine Hydrochloride or Diphenhydramine HCl | |