Specifications, Uses, SDS of Frusemide or Furosemide Manufacturers

	King of Chemicals Manufacturers
Specifications, Properties, Uses, SDS of Frusemide or Furosemide USP BP Ph Eur EP JP IP Grade Manufacturer Supplier Exporter Wholesale & Small Packs, CAS Number 54-31-9.
King of Chemicals has several associated companies having accreditations like cGMP, GLP - FDA Approved Good Manufacturing Practice and Good Laboratory Practice of WHO standard, ISO-9001, ISO-14001, ISO/IEC 17025, ISO ISO-45000, HACCP, FSSC 220000, FSSAI, "REACH" Registered, Kosher & Halal Certified. e-CTD and DMF support can be made available if needed. We offer USP NF BP Ph Eur EP IP JP Analytical Reagent FCC Food Grade Chemicals & Nutraceuticals.

Muby Chem Pvt. Ltd. is a several decades old group of companies, engaged in manufacturing, supplying, distributing, wholesale supplies of Frusemide or Furosemide USP BP Ph Eur EP JP IP Grade for actual users, including retail or small pack supplies for research and development work.

We supply fine and speciality chemicals, pharmaceutical excipients, mineral fortifiers in chemically pure, analytical reagent grade, IP BP USP Ph Eur EP JP and other pharmaceutical grade monograph including FCC Food grade chemicals and Nutraceuticals at best prices. We and/or our associated units have all the facilities to supply as per cGMP standard observing good manufacturing practice and good laboratory practice. We can assure low microbial count and also offer a test certificate for the same. We maintain warehouses across USA, India, and UAE. Our group exports to USA, Canada, Mexico, Argentina, Brazil, Chile, Korea, Malaysia, Thailand, Indonesia, Europe, and several other parts of the world. We supply in wholesale container loads to small pack of few grams. Solid products may be specified for it size and shape as desired by the buyer.

The Properties, Specifications, Monograph and Uses of Frusemide or Furosemide:

Furosemide or Frusemide is an odorless white to slightly yellow crystalline powder. It is used as a diuretic drug. It is almost tasteless.

Furosemide BP Ph Eur Grade Specifications:
C12H11ClN2O5S --- 330.7 CAS54-31-9
Action and use: Loop diuretic.

DEFINITION
4-Chloro-2-[(furan-2-ylmethyl)amino]-5-sulfamoylbenzoic acid.
Content: 98.5 per cent to 101.0 per cent (dried substance).

CHARACTERS
Appearance: White or almost white, crystalline powder.
Solubility: Practically insoluble in water, soluble in acetone, sparingly soluble in ethanol (96 per cent), practically insoluble in methylene chloride. It dissolves in dilute solutions of alkali hydroxides.

IDENTIFICATION
First identification: B
Second identification: A, C
A. Ultraviolet and visible absorption spectrophotometry.
B. Infrared absorption spectrophotometry.
C. Dissolve about 25 mg in 10 mL of ethanol (96 per cent). Mix 5 mL of the solution and 10 mL of water. To 0.2 mL of this solution add 10 mL of dilute hydrochloric acid and heat under a reflux condenser for 15 min. Allow to cool and add 18 mL of 1 M sodium hydroxide and 1 mL of a 5& g/L solution of sodium nitrite. Allow to stand for 3 min, add 2 mL of a 25 g/L solution of sulfamic acid and mix. Add 1 mL of a 5 g/L solution of naphthyl ethylenediamine dihydrochloride. A violet-red colour develops.

Furosemide USP Grade Specifications:
C12H11ClN2O5S -- 330.74
Benzoic acid, 5-(aminosulfonyl)-4-chloro-2-[(2-furanylmethyl)amino]-;
4-Chloro-N-furfuryl-5-sulfamoylanthranilic acid CAS 54-31-9
UNII: 7LXU5N7ZO5

DEFINITION
Furosemide contains NLT 98.0% and NMT 102.0 of furosemide (C12H11ClN2O5S), calculated on the dried basis.

IDENTIFICATION
A. Infrared Absorption
B. The retention time of the major peak of the Sample solution corresponds to that of the Standard solution, as obtained in the Assay.
C. The UV spectrum of the major peak of the Sample solution corresponds to that of the Standard solution, as obtained in the Assay.
Residue on Ignition: NMT 0.1%
Organic Impurities: To pass the test by Chromatography.
Loss on Drying: NMT 1.0% at 105C for 3 h.

Furosemide or Frusemide or 4-chloro-2-((furan-2-ylmethyl)amino)-5-sulfamoylbenzoic acid SDS GHS Safety Data Sheet
MSDS Sheet, Material Safety Data Sheet 28-March-25

Product Name & Other Names: Furosemide or Frusemide or 4-chloro-2-((furan-2-ylmethyl)amino)-5-sulfamoylbenzoic acid.
CAS Number: 54-31-9
EINECS EC Number: 200-203-6
Relevant uses and uses advised against (if any): Fracturing and Industrial Manufacturing Use.
Supplier: As per letterhead.

GHS, Globally Harmonized System Classification in accordance with 29 CFR 1910
Classification according to Regulation (EC) No 1272/2008

Acute toxicity, Oral (Category 4), H302
Reproductive toxicity Category 1B - H360

Hazard Statements:
H302 Harmful if swallowed.
H360: May damage the unborn child. May damage fertility.

Precautionary Statements:
P201: Obtain special instructions before use.
P260: Do not breathe dust/fume/gas/mist/vapors/spray.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P281: Use personal protective equipment as required.
P301+330+331: IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P302 + P352: IF ON SKIN: Wash with plenty of soap and water.
P304+340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305+351+338: IF IN EYES: Rinse cautiously with water for several minutes.
P308 + P310: IF exposed or concerned: immediately call a POISON CENTER or doctor/ physician.

Product Name & Other Names: Furosemide or Frusemide or 4-chloro-2-((furan-2-ylmethyl)amino)-5-sulfamoylbenzoic acid.
CAS Number: 54-31-9
EINECS EC Number: 200-203-6

Inhalation: If inhaled, remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical attention.
Ingestion: Never give anything by mouth to an unconscious person. Get medical attention.
Skin Contact: Immediately flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes. Get medical attention.
Eye Contact: Check for and remove any contact lenses. In case of contact, immediately flush your eyes with plenty of water for at least 15 minutes. Get medical attention if irritation occurs.

Fire: Combustible at high temperature. Vapors are heavier than air and may spread along floors. Forms explosive mixtures with air on intense heating. Development of hazardous combustion gases or vapors is possible in the event of fire. In a fire or if heated, a pressure increase will occur and the container may burst.
Suitable extinguishing media: Water spray, dry powder, foam, carbon dioxide. Avoid solid water stream as it can scatter the fire.
Products of Combustion: Oxides of carbon and sulfur, chlorine compounds, along with toxic fumes will be formed.
Fire Extinguishing Media: Use water spray, alcohol-resistant foam, dry chemical, or carbon dioxide. Use means suitable for extinguishing surrounding fire.
Special Information: In the event of a fire, wear full protective clothing and NIOSH-approved self-contained breathing apparatus with full face piece operated in the positive pressure mode.

Personal precautions, protective equipment, and emergency procedures: Avoid breathing dust/fumes/gas/mist/vapors/spray. Use individual protective equipment (waterproof boots, suitable protective clothing, safety glasses, etc.).
Environmental precautions: Do not let the product enter drains, soil, or water sources.
Methods and materials used for containment cleanup procedures and Storage:
Small Spill: For small spills use appropriate tools to put the spilled solid in a convenient waste disposal container.
Large Spill: Contain spilled material. Cover with an inert, non-combustible absorbent material, (e.g., sand, earth, diatomaceous earth, vermiculite). Use a shovel to put into a convenient waste disposal container.

Precautions for safe handling: Apply according to good manufacturing and industrial hygiene practices. Ensure proper ventilation. Product should be worked up in closed equipment as far as possible. Wash thoroughly after handling. Do not drink, eat, or smoke while handling. Avoid contact with skin, eyes, and clothing. Minimize dust generation. Avoid breathing dust/fumes/gas/mist/vapors/spray. Keep container tightly closed. Avoid ingestion and inhalation. Use individual protective equipment (waterproof boots, suitable protective clothing, safety glasses, etc.).
Conditions for safe storage, including any incompatibilities: Store in cool, dry, and ventilated area away from heat sources and protected from sunlight in tightly closed original container. Keep air contact to a minimum. Do not leave the material container open. Store protected from heat, sparks and ignition sources and incompatible materials. Avoid inhalation of dust/mist/vapor. Do not store with incompatible materials like oxidizing agents. Containers of this material may be hazardous when empty. Storage: Room temperature.

Airborne Exposure Limits: Contains no substances with occupational exposure limit values. Ensure minimum contact.
Ventilation System: A system of local and/or general exhaust is recommended to keep employee exposures below the Airborne Exposure Limits.
Personal Respirators (NIOSH Approved): If the exposure limit is exceeded and engineering controls are not feasible, a full face piece particulate respirator (NIOSH type N100 filters) may be worn for up to 50 times the exposure limit or the maximum use concentration specified by the appropriate regulatory agency or respirator supplier, whichever is lowest.
Skin Protection: Wear impervious protective clothing, including boots, gloves, lab coat, apron or coveralls, as appropriate, to prevent skin contact.
Eye Protection: Use chemical safety goggles and/or full-face shield where dusting or splashing of solutions is possible. Maintain eye wash fountain and quick-drench facilities in work area.

Appearance: Off - white powder.
Odor: Odorless.
Odor threshold: Not applicable.
pH: No information found.
Relative density: No information found.
Melting point/freezing point: 210C to 220C literature.
Initial boiling point and boiling range: 582C predicted.
Flash Point: No information found.
Auto-ignition temperature: No information found.
Decomposition temperature: No information found.
Upper/lower flammability or explosive limits: No information found.
Vapor pressure: No information found.
Vapor density: No information found.
Evaporation rate: No information found.
Flammability (solid, gas): No information found.
Partition coefficient: n-octanol/water: No information found.
Solubility: Very slightly soluble in Water.
Viscosity: No information found.

Stability: It is stable under ordinary conditions of use and storage. Forms explosive mixtures with air on intense heating. Dust explosion for fine distribution, when whirled up in air.
Hazardous Decomposition Products: Toxic gases and vapors may be released if involved in a fire. Oxides of carbon and sulfur, chlorine compounds, along with toxic fumes will be formed.
Hazardous Polymerization: Will not occur.
Incompatibilities: Oxidizing agents.
Conditions to Avoid: Incompatibles, heat, sunlight.

LD50 Oral Rabbit: > 800 mg/kg.
Carcinogenic Effects: Not a reported carcinogen.
Reproductive Toxicity: May damage the unborn child. May damage fertility.
Developmental Toxicity: No information found.

Toxicity to fish: No information found.
Persistence and Degradability: No information found.
Mobility: No information found.
Bioaccumulation/ Accumulation: No information found.
Results of PBT and vPvB assessment: No information found for assessment.

Whatever cannot be saved for recovery or recycling should be managed in an appropriate and approved waste disposal facility. See section 2.

USA:
SARA 311/312: See section 2.
California Proposition 65: Not listed for causing cancer, reproductive harm or birth defects.

Disclaimer:
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Our company provides this MSDS sheet in good faith but makes no representation as to its comprehensiveness or accuracy. This SDS sheet is intended only as a guide to the appropriate precautionary handling of the material by a properly trained person using this product. The above information has been compiled from various sources and has the possibility of discrepancy and being out-dated information. Individuals receiving the information must exercise their independent judgment and do further search in determining its appropriateness for a particular purpose. In no case shall our company be liable to loss or damages by the product user.
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Frusemide or Furosemide Manufacturers, Suppliers, Exporters, Wholesalers:

Plot No. 2900/46&47 + 2900/163to167, GIDC, Ankleshwar, Dist. Bharuch, India
India, USA, UAE
TEL: (Office) 91-22-23774610, 91-22-23723564

If I give you “My Word” Nobody can undo it.
If I sign an “Agreement” my Lawyer will undo it

Our products are for industrial and laboratory use only. The user must test the material before use. We are not dispensing chemists or druggist and do not offer over the counter type (OTC) products for medical use by individuals.

Specifications, Properties, Uses, SDS of Frusemide or Furosemide USP BP Ph Eur EP JP IP Grade Manufacturer Supplier Exporter Wholesale & Small Packs, CAS Number 54-31-9.

Frusemide or Furosemide Manufacturers, Suppliers, Exporters, Wholesalers: