Specifications, Uses, SDS of Dorzolamide Hydrochloride Manufacturers

	King of Chemicals Manufacturers
Specifications, Properties, Uses, SDS of Dorzolamide Hydrochloride USP BP Ph Eur EP Grade Manufacturer Supplier Exporter Wholesale & Small Packs, CAS Number 130693-82-2.
King of Chemicals has several associated companies having accreditations like cGMP, GLP - FDA Approved Good Manufacturing Practice and Good Laboratory Practice of WHO standard, ISO-9001, ISO-14001, ISO/IEC 17025, ISO ISO-45000, HACCP, FSSC 220000, FSSAI, "REACH" Registered, Kosher & Halal Certified. e-CTD and DMF support can be made available if needed. We offer USP NF BP Ph Eur EP IP JP Analytical Reagent FCC Food Grade Chemicals & Nutraceuticals.

Muby Chem Pvt. Ltd. is a several decades old group of companies, engaged in manufacturing, supplying, distributing, wholesale supplies of Dorzolamide Hydrochloride USP BP Ph Eur EP for actual users, including retail or small pack supplies for research and development work.

We supply fine and speciality chemicals, pharmaceutical excipients, mineral fortifiers in chemically pure, analytical reagent grade, IP BP USP Ph Eur EP JP and other pharmaceutical grade monograph including FCC Food grade chemicals and Nutraceuticals at best prices. We and/or our associated units have all the facilities to supply as per cGMP standard observing good manufacturing practice and good laboratory practice. We can assure low microbial count and also offer a test certificate for the same. We maintain warehouses across USA, India, and UAE. Our group exports to USA, Canada, Mexico, Argentina, Brazil, Chile, Korea, Malaysia, Thailand, Indonesia, Europe, and several other parts of the world. We supply in wholesale container loads to small pack of few grams. Solid products may be specified for it size and shape as desired by the buyer.

The Properties, Specifications, Monograph and Uses of Dorzolamide Hydrochloride:

Dorzolamide is commonly used to lower pressure inside the eye in people with open-angle glaucoma or ocular hypertension. Dorzolamide hydrochloride is used in ophthalmic solutions.

General Properties and Specifications of Dorzolamide Hydrochloride or Dorzolamide HCl:
Appearance: White or almost white crystalline powder.
Assay: >99%
Melting Point: 285C literature.
Solubility: Soluble in water.
Storage: Room Temperature. Recommended in a cool and dark place, <15C. Refrigeration should be preferred. Short-term shipping may be ambient.

Dorzolamide Hydrochloride USP Grade Specifications:
C10H16N2O4S3-HCl --- 360.90
4H -Thieno[2,3-b]thiopyran-2-sulfonamide, 4-(ethylamino)-5,6-dihydro-6-methyl-, 7,7-dioxide, monohydrochloride, (4S -trans)-;
(4S ,6S )-4-(Ethylamino)-5,6-dihydro-6-methyl-4H -thieno[2,3-b]thiopyran-2-sulfonamide 7,7-dioxide, monohydrochloride CAS 130693-82-2
UNII: QZO5366EW7
UNII: 9JDX055TW1

DEFINITION
Dorzolamide Hydrochloride contains NLT 99.0% and NMT 101.0% of dorzolamide hydrochloride (C10H16N2O4S3-HCl), calculated on anhydrous basis.

IDENTIFICATION
A. Infrared Absorption
B. The retention time of the major peak of the Sample solution corresponds to that of the Standard solution, as obtained in the Assay.
C. Identification Tests - General, Chloride.

Residue on Ignition: NMT 0.1%, an ignition temperature of 600C being used.
Organic Impurities: To pass the test by chromatography.
Limit of Dorzolamide Hydrochloride Related Compound A: To pass the test by chromatography. Acceptance criteria: NMT 0.5%
Water Determination: on 0.4 g. Acceptance criteria: NMT 0.5%
Packaging and Storage: Preserve in well-closed containers, protected from light, and store at 15C to 30.

Dorzolamide Hydrochloride BP Ph Eur Grade Specifications:
C10H17ClN2O4S3 --- 360.9 CAS 130693-82-2
Action and use: Carbonic anhydrase inhibitor; treatment of glaucoma and ocular hypertension.

DEFINITION
(4S,6S)-4-(Ethylamino)-6-methyl-5,6-dihydro-4H-thieno[2,3-b]thiopyran-2-sulfonamide 7,7-dioxide hydrochloride.
Content: 99.0 per cent to 101.0 per cent (dried substance).

CHARACTERS
Appearance: White or almost white, crystalline powder.
Solubility: Soluble in water, slightly soluble in methanol, very slightly soluble in anhydrous ethanol. It shows polymorphism.

IDENTIFICATION
A. Infrared absorption spectrophotometry.
B. It complies with the test for impurity A (see Tests).
C. It gives reaction (a) of chlorides.

TESTS
Impurity A: To pass the test by Liquid chromatography. --- maximum 0.5 per cent.
Related substances: To pass the test by Liquid chromatography.
Loss on drying: Maximum 0.5 per cent, determined on 1.000 g by drying in an oven at 105C.
Sulfated ash: Maximum 0.1 per cent, determined on 1.0 g.

Dorzolamide Hydrochloride or Dorzolamide HCl SDS, Safety Data Sheet
MSDS Sheet, Material Safety Data Sheet 17-Mar-25

Product Name & Other Names: Dorzolamide Hydrochloride or Dorzolamide HCl.
CAS No.: 130693-82-2
EINECS, EC Number: 620-304-2
Relevant uses and uses advised against (if any): Manufacture of substances
Supplier: As per letterhead.

GHS, Globally Harmonized System Classification in accordance with 29 CFR 1910
Classification according to Regulation (EC) No 1272/2008

Acute toxicity, Oral (Category 4), H302
Specific target organ toxicity - repeated exposure (Category 2), H373

Hazard Statements:
H302: Harmful if swallowed.
H373: May cause damage to organs through prolonged or repeated exposure.

Precautionary Statements:
P260: Do not breathe dust/fume/gas/mist/vapors/spray.
P270: Do not eat, drink or smoke when using this product.
P271: Use only outdoors or in a well-ventilated area.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312: IF SWALLOWED: Call a POISON CENTER or doctor/ physician if you feel unwell.
P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.

Product Name & Other Names: Dorzolamide Hydrochloride or Dorzolamide HCl.
CAS No.: 130693-82-2
EINECS, EC Number: 620-304-2

Eyes: Immediately flush your eyes with excess water for 15 minutes, lifting lower and upper eyelids occasionally.
Skin: Immediately flush skin with excess water for 15 minutes while removing contaminated clothing.
Ingestion: Call Emergency Medical immediately. Rinse your mouth with cold water. Give the victim 1-2 cups of water or milk to drink. Induce vomiting immediately.
Inhalation: Remove to fresh air. If not breathing, give artificial respiration.

Suitable extinguishing media: Use water spray, alcohol-resistant foam, dry chemicals, or carbon dioxide. Avoid solid water jets as it can scatter the fire.
Protective equipment and precautions for firefighters: Use water spray, foam, or dry chemicals to extinguish fire. Firefighters should wear full firefighting turn-out gear and respiratory protection. Cool container with water spray.
Special hazards arising from the substance: Carbon oxides, Nitrogen oxides (NOx), Sulfur oxides, Chlorine compounds.
Special Information: In the event of a fire, wear full protective clothing and NIOSH-approved self-contained breathing apparatus with full face piece operated in the pressure demand or other positive pressure mode.

Personal precautions, protective equipment, and emergency procedures: Avoid breathing dust/fumes/gas/mist/vapors/spray. Use individual protective equipment (waterproof boots, suitable protective clothing, safety glasses, etc.).
Environmental precautions: Do not let the product enter drains, soil, or water sources.
Methods and materials used for containment cleanup procedures and Storage: Do not inhale dust, vapor, mist, or gas. Avoid dust formation. Contain spilled material. Cover with an inert, non-combustible absorbent material, (e.g., sand, earth, diatomaceous earth, vermiculite). Use a shovel to put the material into a convenient waste disposal container.

Precautions for safe handling: Apply according to good manufacturing and industrial hygiene practices. Ensure proper ventilation. In case of insufficient ventilation, wear suitable respiratory equipment. Do not drink, eat, or smoke while handling. Avoid contact with skin, eyes, and clothing. Minimize dust generation. Avoid breathing dust/fumes/gas/mist/vapors/spray. Avoid ingestion and inhalation. Use individual protective equipment (waterproof boots, suitable protective clothing, safety glasses, etc.).
Conditions for safe storage, including any incompatibilities: Store in cool, dry, and ventilated area away from heat sources and protected from sunlight in tightly closed original container. Keep air contact to a minimum. Store protected from heat, sparks and ignition sources and incompatible materials. Avoid inhalation of dust/mist/vapor. Do not store with incompatible materials. Storage: Room Temperature. Recommended in a cool and dark place, <15C. Refrigeration should be preferred.

Exposure guidelines: Not Available.
Ventilation System: A system of local and/or general exhaust is recommended to keep employee exposures as low as possible.
Personal Respirators (NIOSH Approved): For conditions of use where exposure to dust or mist is apparent and engineering controls are not feasible, a particulate respirator may be worn.
Skin Protection: Wear protective gloves and clean body-covering clothing.
Eye Protection: Use chemical safety goggles and/or full-face shield where dusting or splashing of solutions is possible. Maintain eye wash fountain and quick-drench facilities in work area.
Other Control Measures: Maintain good housekeeping in work area. Handle in accordance with good industrial hygiene and safety practice.

Physical state and appearance: Crystalline white to off-white powder.
Odor: No data found.
Odor threshold: No data found.
pH (1% soln/water): No data found.
Relative density: No data found.
Melting Point: 285C literature.
Initial boiling point and boiling range: No data found.
Flash point: No data found.
Auto-ignition temperature: No data found.
Decomposition temperature: No data found.
Upper/lower flammability or explosive limits: No data found.
Vapor pressure: No data found.
Vapor density: No data found.
Evaporation rate: No data found.
Flammability (solid, gas): No data found.
Partition coefficient: n-octanol/water: No data found.
Solubility: Soluble in water.
Viscosity: No information found.

Stability: Stable under normal conditions of use and storage.
Incompatibility: Heat and strong oxidizing agents.
Hazardous Decomposition Products: Carbon oxides, Nitrogen oxides (NOx), Sulfur oxides, Chlorine compounds.
Hazardous Polymerization: Has not been reported.

LD50 Oral - Rat - 1927 mg/kg.
Carcinogenicity: No component of this product present at levels greater than or equal to 0.1% is identified as probable, possible or confirmed human carcinogen by IARC.
May causes damage to organs (Kidney) through prolonged or repeated exposure.
Reproductive Effects: No No data found.
Developmental Effects: No No data found.
Teratogenicity: No data found.

Toxicity to fish: No information found.
Results of PBT and vPvB assessment: This substance/mixture contains no components considered to be either persistent, bioaccumulative and toxic (PBT), or very persistent and very bioaccumulative (vPvB) at levels of 0.1% or higher.

Check with all applicable local, regional, and national laws and regulations. Follow all the pollution control rules.

DOT USA, TDG Canada & ADR/RID Europe: Not Regulated.
IATA & IMDG/IMO: Not Regulated.

USA:
SARA 311/312 Hazard Categories: See section 2.
California Proposition 65: Not listed.

DISCLAIMER: The information and recommendations set forth herein are presented in good faith and believed correct as of the date hereof. It is compiled from various sources, and it is not necessarily all inclusive nor fully adequate in every circumstance. In addition, these suggestions should not be confused with nor followed in violation of applicable laws, regulations, rules, or insurance requirements applicable. This MSDS sheet is intended only as a guide to the appropriate precautionary handling of the material by a professionally trained person using this product. Individuals receiving the information must exercise their independent judgment in determining its appropriateness for a particular purpose.

Dorzolamide Hydrochloride Manufacturers, Suppliers, Exporters, Wholesalers:

Plot No. 2900/46&47 + 2900/163to167, GIDC, Ankleshwar, Dist. Bharuch, India
India, USA, UAE
TEL: (Office) 91-22-23774610, 91-22-23723564

If I give you “My Word” Nobody can undo it.
If I sign an “Agreement” my Lawyer will undo it

Our products are for industrial and laboratory use only. The user must test the material before use. We are not dispensing chemists or druggist and do not offer over the counter type (OTC) products for medical use by individuals.

Specifications, Properties, Uses, SDS of Dorzolamide Hydrochloride USP BP Ph Eur EP Grade Manufacturer Supplier Exporter Wholesale & Small Packs, CAS Number 130693-82-2.

Dorzolamide Hydrochloride Manufacturers, Suppliers, Exporters, Wholesalers: