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King of Chemicals Manufacturers Tryptophan or L-Tryptophan and API BP Ph Eur EP USP NF IP JP ChP PPRC Reagent FCC Food Grade Manufacturer |
Specifications, Properties, Uses, SDS of Tryptophan or L-Tryptophan API USP BP Ph Eur EP IP Grade Manufacturer Supplier Exporter Wholesale & Small Packs, CAS Number 73-22-3. | |
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We supply fine and speciality chemicals, pharmaceutical excipients, mineral fortifiers in chemically pure, analytical reagent grade, API IP BP USP Ph Eur EP JP ChP PPRC and other pharmaceutical grade monograph including FCC Food grade chemicals and Nutraceuticals at best prices. We and/or our associated units have all the facilities to supply as per cGMP standard observing good manufacturing practice and good laboratory practice. We can assure low microbial count and also offer a test certificate for the same. We maintain warehouses across USA, India, and UAE. Our group exports to USA, Canada, Mexico, Argentina, Brazil, Chile, Korea, Malaysia, Thailand, Indonesia, Europe, and several other parts of the world. We supply in wholesale container loads to small pack of few grams. Solid products may be specified for it size and shape as desired by the buyer.
Tryptophan or L-Tryptophan or (S)-2-Amino-3-(3-indolyl)propionic acid or L-α-Amino-3-indolepropionic acid CAS Number 73-22-3
For Properties Specifications Uses of Tryptophan or L-Tryptophan Click Properties, Specifications, Uses, Price, Process of Tryptophan or L-Tryptophan Manufacturer.
For For SDS MSDS Sheet of Tryptophan or L-Tryptophan Click SDS Safety Data Sheet MSDS Sheet of Tryptophan or L-Tryptophan Manufacturer.
The Properties, Specifications, Monograph and Uses of Tryptophan or L-Tryptophan:
Tryptophan or L-Tryptophan or (S)-2-Amino-3-(3-indolyl)propionic acid or L-α-Amino-3-indolepropionic acid serves as a critical building block for protein synthesis and acts as the sole precursor for synthesizing serotonin (a neurotransmitter that regulates mood and sleep), melatonin (a hormone controlling sleep-wake cycles), and niacin (Vitamin B3). People use L-tryptophan for severe PMS symptoms and for quitting smoking. It is also used for athletic performance, depression, insomnia, and many other conditions.
Tryptophan USP Grade Specifications:
C11H12N2O2 204.23
l-Tryptophan CAS 73-22-3
UNII: 8DUH1N11BX
DEFINITION
Tryptophan contains NLT 98.5% and NMT 101.5% of C11H12N2O2, asl-tryptophan, calculated on the dried basis.
IDENTIFICATION
Infrared Absorption
ASSAY
Procedure:
Sample solution: Place 200 mg of Tryptophan in a 125-mL flask. Dissolve in a mixture of 3 mL of formic acid and 50 mL of glacial acetic acid.
Analysis: Titrate with 0.1 N perchloric acid, determining the endpoint potentiometrically. Perform a blank determination and make any necessary correction. Each mL of 0.1 N perchloric acid is equivalent to 20.42 mg of C11H12N2O2.
Acceptance criteria: 98.5%–101.5% on the dried basis.
IMPURITIES
Residue on Ignition: NMT 0.1%
Chloride and Sulfate, Chloride: A 0.73-g portion shows no more chloride than corresponds to 0.50 mL of 0.020 N hydrochloric acid (0.05%). [Note— Gently heat the sample preparation to dissolve, if necessary.]
Chloride and Sulfate, Sulfate: A 0.33-g portion shows no more sulfate than corresponds to 0.10 mL of 0.020 N sulfuric acid (0.03%). [Note— Gently heat the sample preparation to dissolve, if necessary.]
Iron: NMT 30 ppm.
Organic Impurities: to pass the tests by chromatography.
Optical Rotation, Specific Rotation: −29.4° to −32.8°
Sample solution: 10 mg/mL, in water. [Note— Heat gently to dissolve, if necessary.]
pH: 5.5–7.0, in a solution (1 in 100).
Loss on Drying: Dry a sample at 105° for 3 h: it loses NMT 0.3% of its weight.
Tryptophan BP Ph Eur Grade Specifications:
C11H12N2O2 --- 204.2 - CAS 73-22-3
DEFINITION
(2S)-2-Amino-3-(1H-indol-3-yl)propanoic acid.
Product of fermentation or of protein hydrolysis.
Content: 98.5 per cent to 101.0 per cent (dried substance).
CHARACTERS
Appearance: White or almost white, crystalline or amorphous powder.
Solubility: Sparingly soluble in water, slightly soluble in ethanol (96 per cent). It dissolves in dilute solutions of mineral acids and alkali hydroxides.
IDENTIFICATION
First identification: A, B
Second identification: A, C, D
A. Specific optical rotation.
B. Infrared absorption spectrophotometry.
C. Thin-layer chromatography.
D. Dissolve about 20 mg in 10 mL of water. Add 5 mL of dimethylaminobenzaldehyde solution and 2 mL of hydrochloric acid. Heat on a water-bath. A purple blue colour develops.
TESTS
Appearance of solution: The solution is clear and not more intensely coloured than reference solution.
Dissolve 0.1 g in 1 M hydrochloric acid and dilute to 10 mL with the same acid.
Specific optical rotation: -33.0 to -30.0 (dried substance).
Dissolve 0.25 g in water, heating on a water-bath if necessary, and dilute to 25.0 mL with the same solvent.
Ninhydrin-positive substances: To pass the test.
Impurity A and other related substances: To pass the test.
Chlorides: Maximum 200 ppm.
Sulfates: Maximum 300 ppm.
Ammonium: To meet the requirement.
Iron: Maximum 20 ppm.
Loss on drying: Maximum 0.5 per cent, determined on 1.000 g by rying in an oven at 105C.
Sulfated ash: Maximum 0.1 per cent, determined on 1.0 g.
The MSDS-SDS Hazard Statement of Tryptophan or L-Tryptophan:
L-Tryptophan or (S)-2-Amino-3-(3-indolyl)propionic acid or L-α-Amino-3-indolepropionic acid SDS Sheet, Safety Data Sheet
MSDS Sheet, Material Safety Data Sheet
1. Product Identification
Product Name & Other Names: L-Tryptophan or (S)-2-Amino-3-(3-indolyl)propionic acid or L-α-Amino-3-indolepropionic acid.
CAS No.: 73-22-3
EINECS EC Code: 200-795-6
Molecular Weight: 204.23
Chemical Formula: C11H12N2O2
Relevant uses and uses advised against (if any): Industrial Manufacturing.
SUPPLIER: As per letterhead.
2. Hazards Identification
GHS, Globally Harmonized System Classification in accordance with 29 CFR 1910
Classification according to Regulation (EC) No 1272/2008
Not a hazardous substance or mixture according to Regulation (EC) No. 1272/2008.
This substance is not classified as dangerous according to Directive 67/548/EEC.
Labeling according to GHS & Regulation (EC) No 1272/2008
| GHS Label Elements NONE |
Signal Words: None
Precautionary statements:
P261: Avoid breathing dust/fume/gas/mist/vapors/spray.
P262: Do not get in eyes, on skin, or on clothing.
P281: Use personal protective equipment as required.
P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305+P351+ P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+313: If eye irritation persists get medical advice/attention.
3. Composition/Information on Ingredients
Product Name & Other Names: L-Tryptophan or (S)-2-Amino-3-(3-indolyl)propionic acid or L-α-Amino-3-indolepropionic acid.
CAS No.: 73-22-3
EINECS EC Code: 200-795-6
4. First Aid Measures
Always seek medical advice after the first aid treatment.
Inhalation: If inhaled, remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical attention.
Ingestion: Contact medical center quickly. Never give anything by mouth to an unconscious person. Get medical attention.
Skin Contact: Immediately flush skin with plenty of water for at least 15 minutes. Remove contaminated clothing and shoes. Get medical attention. Wash clothing before reuse. Thoroughly clean shoes before reuse.
Eye Contact: Check for and remove any contact lenses. Immediately flush your eyes with running water for at least 15 minutes, keeping eyelids open. Cold water may be used. Get medical attention.
5. Fire Fighting Measures
Combustible at high temperature. High heat or direct flame is necessary to cause ignition. Toxic fumes, carbon monoxide and nitrogen oxides may be formed in fire.
Explosion: At high temperature, explosive vapor-air mixtures may be formed.
Fire Extinguishing Media: Dry chemical, foam, water spray or carbon dioxide. Do not use a solid stream of water since the stream will scatter and spread the fire. Water spray may be used to keep fire exposed containers cool.
Special Information: In the event of a fire, wear full protective clothing and NIOSH-approved self-contained breathing apparatus with full face piece operated in the pressure demand or other positive pressure mode. At high temperatures under fire conditions, it may produce toxic or irritating fumes.
6. Accidental Release Measures
Personal precautions, protective equipment, and emergency procedures: Avoid breathing dust/fumes/gas/mist/vapors/spray. Use individual protective equipment (waterproof boots, suitable protective clothing, safety glasses, etc.).
Environmental precautions: Do not let the product enter drains, soil, or water sources.
Methods and materials used for containment cleanup procedures and Storage: Avoid dust formation. Keep away from heat. Keep away from sources of ignition. Provide ventilation. Contain spilled material. Cover with an inert, non-combustible absorbent material, (e.g., sand, earth, diatomaceous earth, vermiculite). Vacuum or sweep-up and remove to an approved disposal container.
7. Handling and Storage
Precautions for safe handling: Apply according to good manufacturing and industrial hygiene practices. Ensure proper ventilation. Wash thoroughly after handling. Do not drink, eat, or smoke while handling. Avoid contact with skin, eyes, and clothing. Minimize dust generation. Avoid breathing dust/fumes/gas/mist/vapors/spray. Keep container tightly closed. Avoid ingestion and inhalation. Use individual protective equipment (waterproof boots, suitable protective clothing, safety glasses, etc.).
Conditions for safe storage, including any incompatibilities: Keep away from heat and source of fire. Store in cold, dry, and ventilated area away from heat sources and protected from sunlight in tightly closed original container. Keep air contact to a minimum. Do not breathe dust. Do not leave the material container open. Store protected from heat, sparks and ignition sources and incompatible materials. Avoid inhalation of dust/mist/vapor. Do not store with incompatible materials like oxidizing material. Storage: Room temperature.
8. Exposure Controls/Personal Protection
Airborne Exposure Limits: Not established.
Ventilation System: A system of local and/or general exhaust is recommended to keep employee exposures as low as possible.
Personal Respirators (NIOSH Approved): For conditions of use where exposure to the substance is apparent and engineering controls are not feasible, consult an industrial hygienist.
Skin Protection: Wear impervious protective clothing, including boots, gloves, lab coat, apron, or coveralls, as appropriate, to prevent skin contact.
Eye Protection: Use chemical safety goggles and/or a full-face shield where splashing is possible. Maintain eye wash fountain and quick-drench facilities in work area.
Other Control Measures: Maintain good housekeeping in work area. Handle in accordance with good industrial hygiene and safety practice.
9. Physical and Chemical Properties
Appearance: White to off-white crystalline powder.
Odor: Odorless.
Odor threshold: Not applicable.
pH: 5.5 - 7.0
Melting point: 280C to 285C literature.
Boiling point: Not data found.
Relative density: Not data found.
Flash point: Not data found.
Auto-ignition temperature: Not data found.
Decomposition temperature: Not data found.
Upper/lower flammability or explosive limits: Not data found.
Vapor pressure: Not data found.
Vapor density: Not data found.
Evaporation rate: Not data found.
Flammability (solid, gas): Not data found.
Partition coefficient: n-octanol/water: Not data found.
Solubility: Soluble in water.
Viscosity: Not data found.
10. Stability and Reactivity
Stability: Stable under ordinary conditions of use and storage.
Hazardous Decomposition Products: Carbon dioxide, carbon monoxide, nitrogen oxides and toxic fumes may form when heated to decomposition.
Hazardous Polymerization: Not reported. However, it can explode under certain conditions.
Incompatibilities: Strong oxidizing agents, heat, and sparks.
Conditions to Avoid: Heat, flames, sunlight, ignition sources and incompatibles.
11. Toxicological Information
Oral LD50 – Rat - : > 2000 ( Rat ).
LC50 Inhalation - Rat - : > 5,17 mg/l - 4 h.
Carcinogenicity: No component of this product present at levels greater than or equal to 0.1% is identified as possible or confirmed human carcinogen by IARC, ACGIH, OSHA and NTP.
Teratogenic Effects: Not data found.
Mutagenic Effects: Not data found.
Developmental Toxicity: Not data found.
Reproductive Effects: Not data found.
12. Ecological Information
Toxicity to daphnia and other aquatic invertebrates: static test EC50 - Daphnia magna (Water flea) - > 100 mg/l - 48 h.
Mobility: Likely to be mobile due to water solubility.
Persistence and Degradability: Soluble in water. Persistence is unlikely due to water solubility.
Biodegradability: Expected to be biodegradable
Results of PBT and vPvB assessment: Not PBT or vPvB.
13. Disposal Considerations
Whatever cannot be saved for recovery or recycling should be managed in an appropriate and approved waste disposal facility. Dispose of containers and unused contents in accordance with federal, state, and local requirements. Follow all the pollution control rules.
14. Transport Information
DOT USA & ADR/RID Europe: Not dangerous goods.
IMDG/IMO: Not dangerous goods.
IATA/ICAO: Not dangerous goods.
15. Regulatory Information
USA:
SARA 311/312 Hazards: None.
California Prop. 65 Components: Not listed.
Disclaimer:
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Our company provides this MSDS sheet in good faith but makes no representation as to its comprehensiveness or accuracy. This SDS sheet is intended only as a guide to the appropriate precautionary handling of the material by a properly trained person using this product. The above information has been compiled from various sources and has the possibility of discrepancy and being out-dated information. Individuals receiving the information must exercise their independent judgment and do further search in determining its appropriateness for a particular purpose. In no case shall our company be liable to loss or damages by the product user.
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Tryptophan or L-Tryptophan Manufacturers, Suppliers, Exporters, Wholesalers:
King of Chemicals manufacturers
Plot No. 2900/46&47 + 2900/163to167, GIDC, Ankleshwar, Dist. Bharuch, India
India, USA, UAE
TEL: (Office) 91-22-65290111
email: info@kingofchemicals.com
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Our products are for industrial and laboratory use only. The user must test the material before use. We are not despensing chemists or druggist and do not offer over the counter type (OTC) products for medical use by individuals.
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