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King of Chemicals Manufacturers Lamivudine or 3TC and API BP Ph Eur EP USP NF IP JP ChP PPRC Reagent FCC Food Grade Manufacturer |
Specifications, Properties, Uses, SDS of Lamivudine or 3TC API BP Ph Eur USP Grade Manufacturer Supplier Exporter Wholesale & Small Packs, CAS Number 134678-17-4. | |
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Muby Chem Pvt. Ltd. is a several decades old group of companies, engaged in manufacturing, supplying, distributing, wholesale supplies of Lamivudine or 3TC BP Ph Eur USP Grade for actual users, including retail or small pack supplies for research and development work.
We supply fine and speciality chemicals, pharmaceutical excipients, mineral fortifiers in chemically pure, analytical reagent grade, API IP BP USP Ph Eur EP JP ChP PPRC and other pharmaceutical grade monograph including FCC Food grade chemicals and Nutraceuticals at best prices. We and/or our associated units have all the facilities to supply as per cGMP standard observing good manufacturing practice and good laboratory practice. We can assure low microbial count and also offer a test certificate for the same. We maintain warehouses across USA, India, and UAE. Our group exports to USA, Canada, Mexico, Argentina, Brazil, Chile, Korea, Malaysia, Thailand, Indonesia, Europe, and several other parts of the world. We supply in wholesale container loads to small pack of few grams. Solid products may be specified for it size and shape as desired by the buyer.
Lamivudine or 3TC CAS Number 134678-17-4
For Properties Specifications Uses of Lamivudine Click Properties, Specifications, Uses, Price, Process of Lamivudine Manufacturer.
For For SDS MSDS Sheet of Lamivudine Click SDS Safety Data Sheet MSDS Sheet of Lamivudine Manufacturer.
The Properties, Specifications, Monograph and Uses of Lamivudine:
Lamivudine or 3TC is a prescription antiviral medication primarily used to manage human immunodeficiency virus (HIV) and chronic hepatitis B virus (HBV) infections. It belongs to a class of medications called nucleoside reverse transcriptase inhibitors (NRTIs). Rather than acting as a absolute cure, lamivudine works by blocking the enzymes that these viruses need to replicate, effectively slowing down viral reproduction and reducing the overall viral load in the body. In medecine it is used for Combination Therapy for HIV-1, Treatment of Chronic Hepatitis B (HBV), Management of HIV/HBV Co-Infection, etc.
Lamivudine BP Ph Eur Grade Specifications:
C8H11N3O3S --- 229.3 CAS 134678-17-4
Action and use: Nucleoside reverse transcriptase inhibitor; antiviral.
Preparations: Lamivudine Tablets, Zidovudine and Lamivudine Tablets, Abacavir Zidovudine and Lamivudine Tablets, Abacavir and Lamivudine Tablets
DEFINITION
4-Amino-1-[(2R,5S)-2-(hydroxymethyl)-1,3-oxathiolan-5-yl]pyrimidin-2(1H)-one.
Content: 97.5 per cent to 102.0 per cent (dried substance).
CHARACTERS
Appearance: White or almost white powder.
Solubility: Soluble in water, sparingly soluble in methanol, slightly soluble in ethanol (96 per cent).
IDENTIFICATION
First identification: B, C
Second identification: A, B
A. Specific optical rotation: -99 to -97 (dried substance). Dissolve 0.250 g in water R and dilute to 50.0 mL with the same solvent.
B. Infrared absorption spectrophotometry.
C. Enantiomeric purity (see Tests).
TESTS
Absorbance: Maximum 0.3 at 440 nm, using a path length of 4 cm.
Dissolve 1.00 g in water, using sonication if necessary, and dilute to 20.0 mL with the same solvent.
Related substances: To pass the test by Liquid chromatography.
Enantiomeric purity: To pass the test by Liquid chromatography.
Loss on drying: Maximum 0.5 per cent, determined on 1.000 g by drying in an oven at 105C.
Sulfated ash: Maximum 0.1 per cent, determined on 1.0 g.
Storage: Protected from light.
Lamivudine USP Grade Specifications:
C8H11N3O3S --- 229.26
C8H11N3O3S-0.2CH3OH 235.66
C8H11N3O3S-0.2H2O 232.86
2(1H)-Pyrimidinone, 4-amino-1-[2-(hydroxymethyl)-1,3-oxathiolan-5-yl]-, (2R -cis)-;
(–)-1-[(2R,5S)-2-(Hydroxymethyl)-1,3-oxathiolan-5-yl]cytosine CAS 134678-17-4
UNII: 2T8Q726O95
DEFINITION
Lamivudine contains NLT 98.0% and NMT 102.0% of lamivudine (C8H11N3O3S), calculated on an anhydrous and solvent-free basis. If labeled as a methanol solvate, it contains NLT 98.0% and NMT 102.0% of lamivudine (C8H11N3O3S), calculated on anhydrous, methanol-free, and solvent-free basis.
IDENTIFICATION
A. Infrared Absorption
B. The retention time of the major peak of the Sample solution corresponds to that of the System suitability solution, as obtained in the test for Limit of Lamivudine Enantiomer.
Assay: 98.0%–102.0% on the anhydrous, methanol-free, and solvent-free basis.
Content of Methanol (if labeled as lamivudine methanol solvate): To pass the test by chromatography.
Limit of Lamivudine Enantiomer: To pass the test by chromatography.
Other Related Compounds: To pass the test by chromatography.
Residual Solvents: To pass the test by chromatography.
Water Determination: NMT 2.0%
Light Absorption: To pass the test.
Packaging and Storage: Preserve in well-closed, light-resistant containers. Store at room temperature.
The MSDS-SDS Hazard Statement of Lamivudine:
Lamivudine or 3TC SDS, Safety Data Sheet
MSDS Sheet, Material Safety Data Sheet
Section 1: Product and Company Identification
Product Name & Other Names: Lamivudine or 3TC.
CAS No.: 134678-17-4
EINECS, EC Number: 603-844-3
Molecular Weight: 229.26
Chemical Formula: C8H11N3O3S
Relevant uses and uses advised against (if any): Laboratory chemicals, Manufacture of substances
Supplier: As per letterhead.
Section 2: Hazards Identification
GHS, Globally Harmonized System Classification in accordance with 29 CFR 1910
Classification according to Regulation (EC) No 1272/2008
Reproductive toxicity, (Category 2) H361d
Specific target organ toxicity - repeated exposure (Category 2), H373
Labeling according to GHS & Regulation (EC) No 1272/2008
GHS Label Elements Irritant | GHS Label Elements Health Hazard |
Signal Words: Danger
Hazard statements:
H361d: Suspected of damaging the unborn child.
H373: May cause damage to organs through prolonged or repeated exposure.
Precautionary statements:
P260: Do not breathe dust/fume/gas/mist/vapors/spray.
P264 Wash thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P271: Use only outdoors or in a well-ventilated area.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P314: Get Medical advice/attention if you feel unwell.
P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
Section 3: Composition / Information on Ingredients
Product Name & Other Names: Lamivudine or 3TC.
CAS No.: 134678-17-4
EINECS, EC Number: 603-844-3
Section 4: First Aid Measures
Always seek medical attention after first aid measures are provided.
Eyes: Immediately flush your eyes with excess water for 15 minutes, lifting lower and upper eyelids occasionally.
Skin: Immediately flush skin with excess water for 15 minutes while removing contaminated clothing.
Ingestion: Call Emergency Medical immediately. Rinse your mouth with cold water. Give the victim 1-2 cups of water or milk to drink. Induce vomiting immediately.
Inhalation: Remove to fresh air. If not breathing, give artificial respiration.
Section 5: Fire Fighting Measures
Suitable extinguishing media: Use water spray, alcohol-resistant foam, dry chemicals, or carbon dioxide. Avoid solid water jets as they can scatter fire.
Protective equipment and precautions for firefighters: Use water spray, foam, or dry chemicals to extinguish fire. Firefighters should wear full firefighting turn-out gear and respiratory protection. Cool container with water spray. Material is not sensitive to impact or static discharge.
Special hazards arising from the substance: Carbon oxides, Nitrogen oxides (NOx), Sulfur compounds, Fumes.
Special Information: In the event of a fire, wear full protective clothing and NIOSH-approved self-contained breathing apparatus with full face piece operated in the pressure demand or other positive pressure mode. At high temperatures under fire conditions, it may produce toxic or irritating fumes.
Section 6: Accidental Release Measures
Personal precautions, protective equipment, and emergency procedures: Avoid breathing dust/fumes/gas/mist/vapors/spray. Use individual protective equipment (waterproof boots, suitable protective clothing, safety glasses, etc.).
Environmental precautions: Do not let the product enter drains, soil, or water sources.
Methods and materials used for containment cleanup procedures and Storage: Do not inhale dust, vapor, mist, or gas. Avoid dust formation. Contain spilled material. Cover with an inert, non-combustible absorbent material, (e.g., sand, earth, diatomaceous earth, vermiculite). Use a shovel to put the material into a convenient waste disposal container.
Section 7: Handling and Storage Green
Precautions for safe handling: Apply according to good manufacturing and industrial hygiene practices. Ensure proper ventilation. In case of insufficient ventilation, wear suitable respiratory equipment. Do not drink, eat, or smoke while handling. Avoid contact with skin, eyes, and clothing. Minimize dust generation. Avoid breathing dust/fumes/gas/mist/vapors/spray. Keep the container tightly closed. Avoid ingestion and inhalation. Use individual protective equipment (waterproof boots, suitable protective clothing, safety glasses, etc.).
Conditions for safe storage, including any incompatibilities: Store in cool, dry, and ventilated area away from heat sources and protected from sunlight in tightly closed original container. Keep air contact to a minimum. Store protected from heat, sparks and ignition sources and incompatible materials. Avoid contact with skin and eyes. Avoid inhalation of dust/mist/vapor. Do not store with incompatible materials like strong oxidizing agents. Storage: Heat Sensitive. Store at room temperature. Ideally refrigerate.
Section 8: Exposure Controls / Personal Protection
Exposure guidelines: Not Available.
Ventilation System: A system of local and/or general exhaust is recommended to keep employee exposures as low as possible.
Personal Respirators (NIOSH Approved): For conditions of use where exposure to dust or mist is apparent and engineering controls are not feasible, a particulate respirator may be worn.
Skin Protection: Wear protective gloves and clean body-covering clothing.
Eye Protection: Use chemical safety goggles and/or full-face shield where dusting or splashing of solutions is possible. Maintain eye wash fountain and quick-drench facilities in work area.
Other Control Measures: Maintain good housekeeping in work area. Handle in accordance with good industrial hygiene and safety practice.
Section 9: Physical and Chemical Properties
Physical state and appearance: White to Almost white powder or crystals.
Odor: No data found.
Odor threshold: No data found.
pH (1% soln/water):No data found.
Relative density: No data found.
Melting Point: 175C to 179C. Also reported is 160C to 162C. Literature.
Initial boiling point and boiling range: No data found.
Flash point: No data found.
Auto-ignition temperature: No data found.
Decomposition temperature: No data found.
Upper/lower flammability or explosive limits: No data found.
Vapor pressure: No data found.
Vapor density: No data found.
Evaporation rate: No data found.
Flammability (solid, gas): No data found.
Partition coefficient: n-octanol/water: No data found.
Solubility: Soluble in water.
Viscosity: No data found.
Section 10: Stability and Reactivity
Stability: Stable under normal conditions of use and storage.
Incompatibility: Heat, light, and strong oxidizing agents.
Hazardous Decomposition Products: Carbon oxides, Nitrogen oxides (NOx), Sulfur compounds, Fumes.
Hazardous Polymerization: Has not been reported.
Section 11: Toxicology Information
LD50 Oral Rat: No data found.
Carcinogenicity: No component of this product present at levels greater than or equal to 0.1% is identified as probable, possible, or confirmed human carcinogen by IARC.
May cause damage to organs (Kidney) through prolonged or repeated exposure.
Reproductive Effects: Suspected of damaging the unborn child.
Developmental Effects: No information available.
Teratogenicity: No data found.
Inhalation - May cause damage to organs through prolonged or repeated exposure.
Section 12: Ecological Information
Toxicity to daphnia and other aquatic invertebrates: EC50 (Daphnia magna (Water flea)): > 100 mg/l in 48 h.
Results of PBT and vPvB assessment: This substance/mixture contains no components considered to be either persistent, bioaccumulative and toxic (PBT), or very persistent and very bioaccumulative (vPvB) at levels of 0.1% or higher.
Section 13: Disposal Considerations
Check with all applicable local, regional, and national laws and regulations.
Section 14: Transport Information
DOT USA, TDG Canada & ADR/RID Europe: Not dangerous goods.
IATA & IMDG/IMO: Not dangerous goods.
Section 15: Regulatory Information
USA:
SARA 311/312 Hazard Categories: See section 2.
Section 16: Other Information
Disclaimer:
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Our company provides this MSDS sheet in good faith but makes no representation as to its comprehensiveness or accuracy. This SDS sheet is intended only as a guide to the appropriate precautionary handling of the material by a properly trained person using this product. The above information has been compiled from various sources and has the possibility of discrepancy and being out-dated information. Individuals receiving the information must exercise their independent judgment and do further search in determining its appropriateness for a particular purpose. In no case shall our company be liable to loss or damages by the product user.
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Lamivudine Manufacturers, Suppliers, Exporters, Wholesalers:
King of Chemicals manufacturers
Plot No. 2900/46&47 + 2900/163to167, GIDC, Ankleshwar, Dist. Bharuch, India
India, USA, UAE
TEL: (Office) 91-22-65290111
email: info@kingofchemicals.com
Copyright and Usual Disclaimer is Applicable --- November 8, 2026
If I give you “My Word” Nobody can undo it.
If I sign an “Agreement” my Lawyer will undo it
Our products are for industrial and laboratory use only. The user must test the material before use. We are not despensing chemists or druggist and do not offer over the counter type (OTC) products for medical use by individuals.
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