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King of Chemicals Manufacturers Etodolac and API BP Ph Eur EP USP NF IP JP ChP PPRC Reagent FCC Food Grade Manufacturer |
Specifications, Properties, Uses, SDS of Etodolac API BP Ph Eur USP EP Grade Manufacturer Supplier Exporter Wholesale & Small Packs, CAS Number 41340-25-4. | |
| King of Chemicals has several associated companies having accreditations like cGMP, GLP - FDA Approved Good Manufacturing Practice and Good Laboratory Practice of WHO standard, ISO-9001, ISO-14001, ISO/IEC 17025, ISO ISO-45000, HACCP, FSSC 220000, FSSAI, "REACH" Registered, Kosher & Halal Certified. e-CTD and DMF support can be made available if needed. We offer API USP NF BP Ph Eur EP IP JP ChP PPRC Analytical Reagent FCC Food Grade Chemicals & Nutraceuticals. | |
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Muby Chem Pvt. Ltd. is a several decades old group of companies, engaged in manufacturing, supplying, distributing, wholesale supplies of Etodolac BP Ph Eur USP EP Grade for actual users, including retail or small pack supplies for research and development work.
We supply fine and speciality chemicals, pharmaceutical excipients, mineral fortifiers in chemically pure, analytical reagent grade, API IP BP USP Ph Eur EP JP ChP PPRC and other pharmaceutical grade monograph including FCC Food grade chemicals and Nutraceuticals at best prices. We and/or our associated units have all the facilities to supply as per cGMP standard observing good manufacturing practice and good laboratory practice. We can assure low microbial count and also offer a test certificate for the same. We maintain warehouses across USA, India, and UAE. Our group exports to USA, Canada, Mexico, Argentina, Brazil, Chile, Korea, Malaysia, Thailand, Indonesia, Europe, and several other parts of the world. We supply in wholesale container loads to small pack of few grams. Solid products may be specified for it size and shape as desired by the buyer.
Etodolac CAS Number 41340-25-4
For Properties Specifications Uses of Etodolac Click Properties, Specifications, Uses, Price, Process of Etodolac Manufacturer.
For For SDS MSDS Sheet of Etodolac Click SDS Safety Data Sheet MSDS Sheet of Etodolac Manufacturer.
The Properties, Specifications, Monograph and Uses of Etodolac:
Etodolac is a prescription nonsteroidal anti-inflammatory drug (NSAID) primarily used to manage acute pain and reduce inflammation, swelling, and stiffness caused by arthritis. It works by blocking cyclooxygenase (COX) enzymes—showing a higher selectivity for COX-2—which decreases the production of prostaglandins, the chemical messengers responsible for pain and swelling at the site of inflammation. It is used in medecine for Osteoarthritis, Rheumatoid Arthritis, Acute Pain Relief, Postoperative Pain, etc.
Etodolac BP Ph Eur Grade Specifications:
C17H21NO3 --- 287.4 CAS 41340-25-4
Action and use: Cyclo-oxygenase inhibitor; analgesic; anti-inflammatory.
DEFINITION
[(1RS)-1,8-Diethyl-1,3,4,9-tetrahydropyrano[3,4-b]indol-1-yl]acetic acid.
Content: 98.0 per cent to 102.0 per cent (anhydrous substance).
CHARACTERS
Appearance: White or almost white, crystalline powder.
Solubility: Practically insoluble in water, freely soluble in acetone and in ethanol (96 per cent).
IDENTIFICATION
First identification: B
Second identification: A, C
A. Melting point: 144C to 150C.
B. Infrared absorption spectrophotometry.
C. Thin-layer chromatography
TESTS
Related substances: To pass the test by Liquid chromatography.
Chlorides: Maximum 300 ppm.
Water: Maximum 0.5 per cent, determined on 1.00 g.
Sulfated ash: Maximum 0.1 per cent, determined on 1.0 g.
Etodolac USP Grade Specifications:
C17H21NO3 --- 287.35
Pyrano[3,4-b]indole-1-acetic acid, 1,8-diethyl-1,3,4,9-tetrahydro-(±)-.
(±)-1,8-Diethyl-1,3,4,9-tetrahydropyrano [3,4-b]indole-1-acetic acid CAS 41340-25-4
UNII: 2M36281008
Etodolac contains not less than 98.0 percent and not more than 102.0 percent of C17H21NO3, calculated on the anhydrous basis.
Packaging and storage: Preserve in tight containers.
Identification: Infrared Absorption.
Water Determination: not more than 0.5%.
Residue on ignition: not more than 0.1%.
Limit of chloride: To pass the test. --- the limit is not more than 0.3 mg per g.
Limit of alcohol and methanol: To pass the test.
Etodolac EP Grade is also supplied as per monograph.
The MSDS-SDS Hazard Statement of Etodolac:
Etodolac SDS, Safety Data Sheet
MSDS Sheet, Material Safety Data Sheet
1. Product Identification
Product Name & Other Names: Etodolac.
CAS No.: 41340-25-4
EINECS EC Code: 629-689-1
Molecular Weight: 287.36
Molecular Formula: C17H21NO3
Relevant uses and uses advised against (if any): Industrial Manufacturing.
Suppliers: As per letterhead.
2. Hazards Identification
GHS, Globally Harmonized System Classification in accordance with 29 CFR 1910
Classification according to Regulation (EC) No 1272/2008
Acute toxicity, Oral (Category 3) H301
Labeling according to GHS USA & Regulation (EC) No 1272/2008
GHS Label Elements Toxic |
Signal Word: Danger
Hazard Statements:
H301: Toxic if swallowed.
Precautionary Statements
P260: Do not breathe dust/fume/gas/mist/vapors/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P271: Use only outdoors or in a well-ventilated area.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P284: Wear respiratory protection.
P301+P310+330: IF SWALLOWED: Rinse mouth and immediately call a POISON CENTER or doctor/physician.
P302+P352: IF ON SKIN: Wash with soap and water.
P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P405: Store locked up.
3. Composition/Information on Ingredients
Product Name & Other Names: Etodolac.
CAS No.: 41340-25-4
EINECS EC Code: 629-689-1
4. First Aid Measures
Always seek medical attention after first aid measures are provided.
Inhalation: If inhaled, it may cause irritation and damage to nose, throat, and respiratory system. Remove the victim to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical attention.
Ingestion: It will cause irritation to mouth, digestive tract and stomach. Contact medical center quickly. Never give anything by mouth to an unconscious person. Get medical attention.
Skin Contact: On contact, it may be harmful. Immediately flush skin with plenty of water for at least 15 minutes. Remove contaminated clothing and shoes. Get medical attention. Wash clothing before reusing. Thoroughly clean shoes before reuse.
Eye Contact: It may cause severe irritation to eyes. Check for and remove any contact lenses. Immediately flush your eyes with running water for at least 15 minutes, keeping eyelids open. Cold water may be used. Get medical attention.
Notes to Physician: Treat symptomatically.
5. Fire Fighting Measures
Toxic fumes, carbon dioxide, carbon monoxide and nitrogen oxides may be formed in fire.
Explosion: Not known.
Fire Extinguishing Media: Dry chemical, foam or carbon dioxide and water spray jet. Avoid solid streams of water.
Special Information: In the event of a fire, wear full protective clothing and NIOSH-approved self-contained breathing apparatus with full face piece operated in the pressure demand or other positive pressure mode. Fire-extinguishing work is done from the windward and a suitable fire-extinguishing method according to the surrounding situation is used.
6. Accidental Release Measures
Personal precautions, protective equipment, and emergency procedures: Avoid breathing dust/fumes/gas/mist/vapors/spray. Use individual protective equipment (waterproof boots, suitable protective clothing, safety glasses, etc.).
Environmental precautions: Do not let the product enter drains, soil, or water sources.
Methods and materials used for containment cleanup procedures and Storage: Do not inhale dust, vapors, mist, or gas. Avoid dust formation. Contain spilled material. Cover with an inert, non-combustible absorbent material, (e.g., sand, earth, diatomaceous earth, vermiculite). Use a shovel to put the material into a convenient waste disposal container.
7. Handling and Storage
Precautions for safe handling: Apply according to good manufacturing and industrial hygiene practices. Ensure proper ventilation. In case of insufficient ventilation, wear suitable respiratory equipment. Wash thoroughly after handling it. Do not drink, eat, or smoke while handling. Avoid contact with skin, eyes, and clothing. Minimize dust generation. Avoid breathing dust/fumes/gas/mist/vapors/spray. Keep container tightly closed. Avoid ingestion and inhalation. Use individual protective equipment (waterproof boots, suitable protective clothing, safety glasses, etc.).
Conditions for safe storage, including any incompatibilities: Store in cool, dry, and ventilated area away from heat sources and protected from sunlight in tightly closed original container. Keep air contact to a minimum. Store protected from heat, sparks and ignition sources and incompatible materials. Avoid inhalation of dust/mist/vapor. Do not store with incompatible materials like strong oxidizing agents. Storage: Refrigerated (2C-8C). Heat Sensitive. Short term shipping may be at room temperature.
8. Exposure Controls/Personal Protection
Airborne Exposure Limits: Not established.
Ventilation System: A system of local and/or general exhaust is recommended to keep employee exposures as low as possible.
Personal Respirators (NIOSH Approved): For conditions of use where exposure to the substance is apparent and engineering controls are not feasible, consult an industrial hygienist.
Skin Protection: Wear impervious protective clothing, including boots, gloves, lab coat, apron or coveralls, as appropriate, to prevent skin contact.
Eye Protection: Use chemical safety goggles and/or a full-face shield where splashing is possible. Maintain eye wash fountain and quick-drench facilities in work area.
Other Control Measures: Maintain good housekeeping in work area. Handle in accordance with good industrial hygiene and safety practice.
9. Physical and Chemical Properties
Appearance: White or almost white, crystalline powder.
Odor:No data found.
Odor threshold: No data found.
pH: No data found.
Relative density: about 0.96
Boiling Point:No data found.
Melting Point: 144C to150C literature.
Flash point: No data found.
Auto-ignition temperature: No data found.
Decomposition temperature: No data found.
Upper/lower flammability or explosive limits: No data found.
Vapor pressure: No data found.
Vapor density: No data found.
Evaporation rate: No data found.
Flammability (solid, gas): No data found.
Partition coefficient: n-octanol/water: No data found.
Solubility: Practically insoluble in water, Soluble in Methanol, thanol, Acetone, DMSO.
Viscosity: No data found.
10. Stability and Reactivity
Stability: Stable under ordinary conditions of use and storage. Forms explosive mixtures with air on intense heating.
Hazardous Decomposition Products: Carbon dioxide, carbon monoxide, nitrogen oxides, and toxic fumes may form when heated to decomposition.
Hazardous Polymerization: Not reported.
Incompatibilities: Strong oxidizing, heat and sparks.
Conditions to Avoid: Sunlight, heat, flames, ignition sources and incompatibles.
11. Toxicological Information
LD50 Oral - Rat - 94 mg/kg.
Carcinogenicity: No component of this product present at levels greater than or equal to 0.1% is identified as probable, possible or confirmed human carcinogen by IARC, ACGIH, OSHA & NTP.
Mutagenic Effects: No data found.
Reproductive Effects: No data found.
Developmental Effects: No data found.
Teratogenicity: No data found.
12. Ecological Information
Toxic to fish: No data found.
Persistence and Degradability: No data found.
Bioaccumulation/ Accumulation: No data found.
Mobility: No data found.
13. Disposal Considerations
Whatever cannot be saved for recovery, or recycling should be managed in an appropriate and approved waste disposal facility. Follow all the pollution control rules.
14. Transport Information
DOT USA & ADR/RID Europe
UN Number: 2811
Proper shipping name: Toxic solid, organic, n.o.s. (Etodolac)
Class: 6.1, Packing group: III.
IMDG & IATA
UN Number: 2811
Proper shipping name: Toxic solid, organic, n.o.s. (Etodolac)
Class: 6.1, Packing group: III.
15. Regulatory Information
USA:
SARA 311/312: See section 2.
Section 16 - Additional Information
Disclaimer:
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Our company provides this MSDS sheet in good faith but makes no representation as to its comprehensiveness or accuracy. This SDS sheet is intended only as a guide to the appropriate precautionary handling of the material by a properly trained person using this product. The above information has been compiled from various sources and has the possibility of discrepancy and being out-dated information. Individuals receiving the information must exercise their independent judgment and do further search in determining its appropriateness for a particular purpose. In no case shall our company be liable to loss or damages by the product user.
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Etodolac Manufacturers, Suppliers, Exporters, Wholesalers:
King of Chemicals manufacturers
Plot No. 2900/46&47 + 2900/163to167, GIDC, Ankleshwar, Dist. Bharuch, India
India, USA, UAE
TEL: (Office) 91-22-65290111
email: info@kingofchemicals.com
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Our products are for industrial and laboratory use only. The user must test the material before use. We are not despensing chemists or druggist and do not offer over the counter type (OTC) products for medical use by individuals.
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