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King of Chemicals Manufacturers Doxylamine Succinate and API BP Ph Eur EP USP NF IP JP ChP PPRC Reagent FCC Food Grade Manufacturer |
Specifications, Properties, Uses, SDS of Doxylamine Succinate BP Ph Eur USP Grade Manufacturer Supplier Exporter Wholesale & Small Packs, CAS Number 562-10-7. | |
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Muby Chem Pvt. Ltd. is a several decades old group of companies, engaged in manufacturing, supplying, distributing, wholesale supplies of Doxylamine Succinate BP Ph Eur USP Grade for actual users, including retail or small pack supplies for research and development work.
We supply fine and speciality chemicals, pharmaceutical excipients, mineral fortifiers in chemically pure, analytical reagent grade, API IP BP USP Ph Eur EP JP ChP PPRC and other pharmaceutical grade monograph including FCC Food grade chemicals and Nutraceuticals at best prices. We and/or our associated units have all the facilities to supply as per cGMP standard observing good manufacturing practice and good laboratory practice. We can assure low microbial count and also offer a test certificate for the same. We maintain warehouses across USA, India, and UAE. Our group exports to USA, Canada, Mexico, Argentina, Brazil, Chile, Korea, Malaysia, Thailand, Indonesia, Europe, and several other parts of the world. We supply in wholesale container loads to small pack of few grams. Solid products may be specified for it size and shape as desired by the buyer.
Doxylamine Succinate CAS Number 562-10-7
For Properties Specifications Uses of Doxylamine Succinate Click Properties, Specifications, Uses, Price, Process of Doxylamine Succinate Manufacturer.
For For SDS MSDS Sheet of Doxylamine Succinate Click SDS Safety Data Sheet MSDS Sheet of Doxylamine Succinate Manufacturer.
The Properties, Specifications, Monograph and Uses of Doxylamine Succinate:
Doxylamine succinate is a first-generation antihistamine primarily used as a short-term sleep aid to treat insomnia and, in combination with vitamin B6 (pyridoxine), to treat nausea and vomiting during pregnancy. It has a pronounced sedative effect. I medecine it is used to treat Short-Term Sleep Aid, Pregnancy-Induced Nausea and Vomiting, Nighttime Cold and Flu Relief, Allergy Symptoms, etc.
Doxylamine Succinate BP Ph Eur Grade Specifications:
C21H28N2O5 --- 388.5 CAS 562-10-7
Action and use: Histamine H1 receptor antagonist; antihistamine.
DEFINITION
N,N-Dimethyl-2-[(1RS)-1-phenyl-1-(pyridin-2-yl)ethoxy]ethanamine hydrogen butanedioate.
Content: 99.0 per cent to 101.0 per cent (anhydrous substance).
CHARACTERS
Appearance: White or almost white powder.
Solubility: Very soluble in water, freely soluble in ethanol (96 per cent).
IDENTIFICATION
Infrared absorption spectrophotometry.
Related substances: To pass the test by Gas chromatography.
Water: Maximum 0.5 per cent, determined on 2.00 g.
Sulfated ash: Maximum 0.1 per cent, determined on 1.0 g.
Doxylamine Succinate USP Grade Specifications:
C17H22N2O-C4H6O4 --- 388.46
Ethanamine, N,N-dimethyl-2-[1-phenyl-1-(2-pyridinyl)ethoxy]-, butanedioate (1:1).
2-[α-[2-(Dimethylamino)ethoxy]-α-methylbenzyl]pyridine succinate (1:1) CAS 562-10-7
UNII: V9BI9B5YI2
UNII: 95QB77JKPL
Doxylamine Succinate contains not less than 98.0 percent and not more than 101.0 percent of C17H22N2O-C4H6O4 , calculated on the dried basis.
Packaging and storage: Preserve in well-closed, light-resistant containers.
Identification:
A: Ultraviolet absorption.
B: It meets the requirements under Identification—Organic Nitrogenous Bases.
C: To pass the test.
Melting range: between 103C and 108C, but the range between beginning and end of melting does not exceed 3C.
Loss on drying: Dry it in vacuum over phosphorus pentoxide for 5 hours: it loses not more than 0.5% of its weight.
Residue on ignition: not more than 0.1%.
Volatile related compounds: To pass the test.
The MSDS-SDS Hazard Statement of Doxylamine Succinate:
Doxylamine Succinate SDS, Safety Data Sheet
MSDS Sheet, Material Safety Data Sheet
1. Product Identification
Product Name/Synonyms: Doxylamine Succinate.
CAS No.: 562-10-7
EINECS EC Number: 209-228-7
Molecular Weight: 388.46
Chemical Formula: C17H22N2O·C4H6O4
Relevant uses and uses advised against (if any): Industrial Manufacturing.
Suppliers: As per letterhead.
2. Hazards Identification
GHS, Globally Harmonized System Classification in accordance with 29 CFR 1910
Classification according to Regulation (EC) No 1272/2008
Acute toxicity, oral Category 4
Labeling according to Regulation (EC) No 1272/2008
GHS Label Elements Harmful |
Signal Words: Warning
Hazard statements:
H302: Harmful if swallowed.
Precautionary statements:
P262: Do not get in eyes, on skin, or on clothing.
P264: Wash skin thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P270: Do not eat, drink or smoke when using this product.
P273: Avoid release to the environment.
P330: Rinse mouth.
P362: Take off contaminated clothing and wash before reuse.
P301+312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell.
P332+313: If skin irritation occurs: Get medical advice/attention.
P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+P313 If eye irritation persists: Get medical advice/ attention.
P501: Dispose of contents/container to authorized agents only.
Labeling in accordance with Directive 67/548/EEC:
Hazard Symbol:
Xn Harmful
Risk Phrase:
R22: Harmful if swallowed.
3. Composition/Information on Ingredients
Product Name/Synonyms:Doxylamine Succinate.
CAS No.:562-10-7
EINECS EC Number: 209-228-7
4. First Aid Measures
Inhalation:Remove to fresh air. Give oxygen if breathing is difficult; give artificial respiration if breathing has stopped. Keep person warm and quiet; get medical attention.
Ingestion:Induce vomiting immediately as directed by medical personnel. Never give anything by mouth to an unconscious person.
Skin Contact: Immediately flush skin with plenty of soap and water for at least 15 minutes. Remove contaminated clothing and shoes. Wash clothing before reuse. Thoroughly clean shoes before reuse. Get medical attention if irritation develops.
Eye Contact: Immediately flush eyes with plenty of water for at least 15 minutes, lifting upper and lower eyelids occasionally. Get medical attention.
Notes to Physician: Treat symptomatically.
5. Fire Fighting Measures
Fire: It is not considered to be a fire hazard. However, it will burn at high temperature.
Fire Extinguishing Media: Use water spray, alcohol-resistant foam, dry chemical, or carbon dioxide. Use water spray to cool fire-exposed containers.
Special hazards arising from the substance or mixture: Carbon oxides, Nitrogen oxides (NOx), and Fumes.
Special Information: In the event of a fire, wear full protective clothing and NIOSH-approved self-contained breathing apparatus with full face piece.
6. Accidental Release Measures
Personal precautions, protective equipment, and emergency procedures: Use personal protective equipment. Ventilate area of leak or spill. Avoid breathing dust/fumes/gas/mist/vapors/spray. Use individual protective equipment (waterproof boots, suitable protective clothing, safety glasses, etc.). Restrict unprotected personnel from the area. Prevent any contact with hot surfaces. Do not approach facing the wind. Do not touch the spilled material.
Environmental precautions: Do not let the product enter drains, soil, or water sources.
Methods and materials used for containment cleanup procedures and Storage: Contain spilled material. Pick up spills and place them in a suitable container for reclamation or disposal, using a method that does not generate dust.
7. Handling and Storage
Precautions for safe handling: Apply according to good manufacturing and industrial hygiene practices. Ensure proper ventilation. Wear personal protective equipment. Avoid ingestion and inhalation. Wash thoroughly after handling. Do not drink, eat, or smoke while handling. Avoid contact with skin, eyes, and clothing. Minimize dust generation. Avoid breathing dust/fumes/gas/mist/vapors/spray. Keep container tightly closed. Avoid ingestion and inhalation. Use individual protective equipment (waterproof boots, suitable protective clothing, safety glasses, etc.). Prevent any contact with hot surfaces.
Conditions for safe storage, including any incompatibilities: Store in cool, dry, and ventilated area away from heat sources and protected from sunlight in tightly closed original container. Keep air contact to a minimum. Do not leave the material container open. Store protected from heat, sparks and ignition sources and incompatible materials. Avoid contact with skin and eyes. Avoid inhalation of dust/mist/vapor. Do not store with incompatible materials like strong oxidizing agents. Avoid dust formation and control ignition sources. Storage: Preferably Frozen. <0C. Light Sensitive and Heat Sensitive.
8. Exposure Controls/Personal Protection
Airborne Exposure Limits: None established.
Ventilation System: In general, dilution ventilation is a satisfactory health hazard control for this substance. However, if conditions of use create discomfort to the worker, a local exhaust system should be considered.
Personal Respirators (NIOSH Approved): Not expected to require personal respirator usage. For conditions of use where exposure to dust or mist is apparent and engineering controls are not feasible, a particulate respirator (NIOSH type N95 or better filters) may be worn. If oil particles (e.g., lubricants, cutting fluids, glycerin, etc.) are present, use a NIOSH type R or P filter. For emergencies or instances where the exposure levels are not known, use a full-face positive-pressure, air-supplied respirator.
Skin Protection: Wear protective gloves and clean body-covering clothing.
Eye Protection: Use chemical safety goggles and/or full-face shield where dusting or splashing of solutions is possible. Maintain eye wash fountain and quick-drench facilities in work area.
9. Physical and Chemical Properties
Appearance: White or almost white powder.
Odor: Not available.
Odor threshold: Not available.
pH: Not available.
Relative density: Not available.
Boiling Point: Not available.
Melting Point: 103C to 108C.
Flash point: Not available.
Auto-ignition temperature: Not available.
Decomposition temperature: Not available.
Upper/lower flammability or explosive limits: Not available.
Vapor pressure: Not available.
Vapor density: Not available.
Evaporation rate: Not available.
Flammability (solid, gas): Not available.
Partition coefficient: n-octanol/water: Not available.
Solubility: Soluble in water. Soluble in Chloroform, Alcohol
Viscosity: Not available.
Molecular Weight: 388.46
Chemical Formula: C17H22N2O·C4H6O4
10. Stability and Reactivity
Stability: Stable under recommended conditions of use and storage.
Hazardous Decomposition Products: May produce oxides of nitrogen, carbon, along with fumes when heated to decomposition.
Hazardous Polymerization: Will not occur.
Incompatibilities: Strong oxidizing agents. Acids. Bases.
Conditions to Avoid: Heat, flame, ignition sources, dusting, and incompatibles.
11. Toxicological Information
Toxicity Data: Oral LD50 Mouse 470 mg/kg.
Carcinogenic Effects: Not a reported carcinogen by IARC, NTP, ACGIH, OSHA.
Mutagenic Effects: No information available
Reproductive Effects: No information available.
Developmental Effects: No information available.
12. Ecological Information
Environmental Fate: Not available. May cause long lasting harmful effects to aquatic life.
Persistence and degradability: No data available.
Toxicity: No data available.
Bioaccumulative potential: No data available.
Mobility in soil: No data available.
PBT and vPvB assessment: No data available.
13. Disposal Considerations
Whatever cannot be saved for recovery or recycling should be managed in an appropriate and approved waste disposal facility. Processing use or contamination of this product may change the waste management options. Dispose of containers and unused material in accordance with legal requirements.
14. Transport Information
Land Transport DOT USA, TDG Canada & ADR/RID Europe: Not dangerous goods.
Sea Transport IMDG/IMO: Not dangerous goods.
Air Transport IATA/ICAO: Not dangerous goods.
15. Regulatory Information
USA:
SARA 311/312 Hazardous Categorization: Acute Health Hazard.
California Proposition 65: This product does not contain any Proposition 65 chemicals.
16. Other Information
Xn Harmful
R22: Harmful if swallowed.
Disclaimer:
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Our company provides this MSDS sheet in good faith but makes no representation as to its comprehensiveness or accuracy. This SDS sheet is intended only as a guide to the appropriate precautionary handling of the material by a properly trained person using this product. The above information has been compiled from various sources and has the possibility of discrepancy and being out-dated information. Individuals receiving the information must exercise their independent judgment and do further search in determining its appropriateness for a particular purpose. In no case shall our company be liable to loss or damages by the product user.
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Doxylamine Succinate Manufacturers, Suppliers, Exporters, Wholesalers:
King of Chemicals manufacturers
Plot No. 2900/46&47 + 2900/163to167, GIDC, Ankleshwar, Dist. Bharuch, India
India, USA, UAE
TEL: (Office) 91-22-65290111
email: info@kingofchemicals.com
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Our products are for industrial and laboratory use only. The user must test the material before use. We are not despensing chemists or druggist and do not offer over the counter type (OTC) products for medical use by individuals.
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