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Specifications, Properties, Uses, SDS of HPMCAS or Hypromellose Acetate Succinate USP NF Grade Hydroxypropyl Methyl Cellulose Acetate Succinate Manufacturer Supplier Exporter Wholesale & Small Packs, CAS Number 71138-97-1. |
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Muby Chem Pvt. Ltd. is a several decades old group of companies, engaged in manufacturing, supplying, distributing, wholesale supplies of Hypromellose Acetate Succinate or Hydroxypropyl Methyl Cellulose Acetate Succinate for actual users, including retail or small pack supplies for research and development work.
We supply fine and speciality chemicals, pharmaceutical excipients, mineral fortifiers in chemically pure, analytical reagent grade, IP BP USP Ph Eur EP JP and other pharmaceutical grade monograph including FCC Food grade chemicals and Nutraceuticals at best prices. We and/or our associated units have all the facilities to supply as per cGMP standard observing good manufacturing practice and good laboratory practice. We can assure low microbial count and also offer a test certificate for the same. We maintain warehouses across USA, India, and UAE. Our group exports to USA, Canada, Mexico, Argentina, Brazil, Chile, Korea, Malaysia, Thailand, Indonesia, Europe, and several other parts of the world. We supply in wholesale container loads to small pack of few grams. Solid products may be specified for it size and shape as desired by the buyer.
HPMCAS or Hypromellose Acetate Succinate or Hydroxypropyl Methyl Cellulose Acetate Succinate CAS Number 71138-97-1
For Properties Specifications Uses of HPMCAS or Hypromellose Acetate Succinate or Hydroxypropyl Methyl Cellulose Acetate Succinate Click Properties, Specifications, Uses, Price, Process of HPMCAS or Hypromellose Acetate Succinate or Hydroxypropyl Methyl Cellulose Acetate Succinate Manufacturer.
For For SDS MSDS Sheet of HPMCAS or Hypromellose Acetate Succinate or Hydroxypropyl Methyl Cellulose Acetate Succinate Click SDS Safety Data Sheet MSDS Sheet of HPMCAS or Hypromellose Acetate Succinate or Hydroxypropyl Methyl Cellulose Acetate Succinate Manufacturer.
The Properties, Specifications, Monograph and Uses of HPMCAS or Hypromellose Acetate Succinate or Hydroxypropyl Methyl Cellulose Acetate Succinate:
Hydroxypropyl methylcellulose acetate succinate or hypromellose acetate succinate or HPMC-AS is an enteric coating material used for both regular enteric coating and sustained release formulations and solid dispersion. There are several types of HPMC-AS, which dissolve at different pH levels. Hypromellose Acetate Succinate or HPMC-AS is recogonized as GRAS (Generally Recognized as Safe) for use in foods.
Specifications of HPMCAS or Hypromellose Acetate Succinate or Hydroxypropyl Methyl Cellulose Acetate Succinate:
Appearance: White to off-white powder or granules.
Loss on drying: 5% maximum.
Residue on ignition: 0.2% maximum.
Heavy metals: 10 ppm maximum.
Arsenic: 2 ppm maximum.
Specifications of Hypromellose Acetate Succinate USP NF Grade:
Hydroxypropyl methylcellulose acetate succinate;
Cellulose, 2-hydroxypropyl methyl ether, acetate hydrogen butanedioate;
Cellulose, 2-hydroxypropyl methyl ether, acetate succinate --- [CAS 71138-97-1].
DEFINITION
Hypromellose Acetate Succinate is a mixture of acetic acid and monosuccinic acid esters of hydroxypropyl methylcellulose. It contains NLT 12.0% and NMT 28.0% of methoxy groups (– OCH3 ), NLT 4.0% and NMT 23.0% of hydroxypropoxy groups (– OCH2CHOHCH3 ), NLT 2.0% and NMT 16.0% of acetyl groups (– COCH3 ), and NLT 4.0% and NMT 28.0% of succinoyl groups (– COC2H4COOH), calculated on the dried basis.
IDENTIFICATION
A. Infrared Absorption:
To pass the test.
Acceptance criteria: The IR spectrum of the Sample exhibits maxima only at the same wavelengths as a similarly obtained spectrum of USP Hypromellose Acetate Succinate.
ASSAY
Acetyl and Succinoyl Groups:
To pass the test by Chromatography
Acceptance criteria:
Acetyl groups (– COCH3 ): 2.0%–16.0% on the dried basis
Succinoyl groups (– COC2H4COOH): 4.0%–28.0% on the dried basis
Content of Methoxy and 2-Hydroxypropoxy Groups:
To pass the test by Chromatography
Acceptance criteria
Methoxy groups (– OCH3 ): 12.0%–28.0% on the dried basis
Hydroxypropoxy groups (– OCH2CHOHCH3 ): 4.0%–23.0% on the dried basis
Analysis: Determine at 600 ± 50C.
Acceptance criteria: NMT 0.20%
Limit of Free Acetic and Succinic Acids:
To pass the test.
Acceptance criteria: The sum of free acetic acid and free succinic acid is NMT 1.0%.
Loss on Drying:
Analysis: Dry at 105C for 1 h.
Acceptance criteria: NMT 5.0%
Viscosity—Capillary Methods:
To pass the test.
Acceptance criteria: 80%–120% of that stated on the label
Packaging and Storage: Preserve in tight containers. No storage requirements specified.
Labeling: Label it to indicate its nominal viscosity type.
The MSDS-SDS Hazard Statement of HPMCAS or Hypromellose Acetate Succinate or Hydroxypropyl Methyl Cellulose Acetate Succinate:
HPMCAS or Hypromellose Acetate Succinate or Hydroxypropyl Methyl Cellulose Acetate Succinate SDS GHS, Safety Data Sheet
MSDS Sheet, Material Safety Data Sheet 18-Apr-22
Section 1: Chemical Product and Company Identification
Product Name & Other Names: HPMCAS or Hypromellose Acetate Succinate or Hydroxypropyl Methyl Cellulose Acetate Succinate.
CAS Number: 71138-97-1
EINECS EC Code: 615-255-9
Relevant uses and uses advised against (if any): Industrial Manufacturing.
Suppliers: As per letterhead.
Section 2: Hazards Identification
GHS, Globally Harmonized System Classification in accordance with 29 CFR 1910
Hazard Class and Category Code(s), Regulation (EC) No 1272/2008 (CLP)
Not a hazardous substance or mixture according to Regulation (EC) No. 1272/2008.
This substance is not classified as dangerous according to Directive 67/548/EEC.
Labeling Regulation as per GHS & EC 1272/2008 (CLP) & GHS
GHS Label Elements NONE |
Signal Word: None
Precautionary statements:
P261: Avoid breathing dust/fume/gas/mist/vapors/spray.
P281: Use personal protective equipment as required.
P302+P352 - IF ON SKIN: Wash with plenty of soap and water.
P304 + P340 - IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338 - IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
Section 3: Composition and Information on Ingredients
Product Name & Other Names: HPMCAS or Hypromellose Acetate Succinate or Hydroxypropyl Methyl Cellulose Acetate Succinate.
CAS Number: 71138-97-1
EINECS EC Code: 615-255-9
Section 4: First Aid Measures
Always seek medical advice after the first aid treatment.
Skin: Rinse with water. Soap may be used. Seek Medical Aid.
Eyes: Wash eyes with plenty of water for at least 15 minutes, lifting lids occasionally. Seek Medical Aid.
Inhalation: Remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen.
Ingestion: If swallowed, induce vomiting immediately after giving two glasses of water. Never give anything by mouth to an unconscious person.
Section 5: Fire and Explosion Data
Products of Combustion: Oxides of Carbon.
Fire Fighting Media and Instructions: Use water spray, alcohol-resistant foam, dry chemical, or carbon dioxide. Wear self-contained breathing apparatus for firefighting if necessary.
Extinguishing Media Not recommended: Avoid using solid water jet as it may scatter the fire.
Special Information: In the event of a fire, wear full protective clothing and NIOSH-approved self-contained breathing apparatus with full face piece operated in the pressure demand or other positive pressure mode. At high temperatures under fire conditions, it may produce toxic or irritating fumes. Fire-extinguishing work is done from the windward and the suitable fire-extinguishing method according to the surrounding situation is used. Uninvolved persons should evacuate to a safe place.
Section 6: Accidental Release Measures
Personal precautions, protective equipment, and emergency procedures: Avoid breathing dust/fumes/gas/mist/vapors/spray. Ensure adequate ventilation. Use individual protective equipment (waterproof boots, suitable protective clothing, safety glasses, etc.). Prevent any contact with hot surfaces. Do not approach facing the wind. Do not touch the spilled material.
Environmental precautions: Do not let the product enter drains, soil, or water sources.
Methods and materials used for containment cleanup procedures and Storage: Contain spilled material. Do not inhale vapors, mist, or gas. Avoid dust formation. Use a shovel to put the material into a convenient waste disposal container.
Section 7: Handling and Storage
Precautions for safe handling: Apply according to good manufacturing and industrial hygiene practices. Ensure proper ventilation. Wash thoroughly after handling. Do not drink, eat, or smoke while handling. Avoid contact with skin, eyes, and clothing. Minimize dust generation. Avoid breathing dust/fumes/gas/mist/vapors/spray. Use individual protective equipment (waterproof boots, suitable protective clothing, safety glasses, etc.). Prevent any contact with hot surfaces.
Conditions for safe storage, including any incompatibilities: Store in cool, dry, and ventilated area away from heat sources and protected from sunlight in tightly closed original container. Keep air contact to a minimum. Do not leave the material container open. Store protected from heat, sparks and ignition sources and incompatible materials. Avoid contact with skin and eyes. Do not store with incompatible materials like oxidizing agents, acids.
Section 8: Exposure Controls/Personal Protection
Exposure Guidelines: This product does not contain any hazardous materials with occupational exposure limits established by the region-specific regulatory bodies.
Engineering Controls: Use process enclosures, local exhaust ventilation, or other engineering controls to keep airborne levels below recommended exposure limits. If user operations generate dust, fume, or mist, use ventilation to keep exposure to airborne contaminants below the exposure limit.
Ventilation System: A system of local and/or general exhaust is recommended to keep employee exposures as low as possible. Local exhaust ventilation is generally preferred because it can control the emissions of the contaminant at its source, preventing dispersion of it into work area.
Personal Respirators (NIOSH Approved): For conditions of use where exposure to dust or mist is apparent and engineering controls are not feasible, a particulate respirator may be worn. For emergencies or instances where the exposure levels are not known, use a full-face positive-pressure, air-supplied respirator.
Skin Protection: Wear protective gloves and clean body-covering clothing.
Eye Protection: Use chemical safety goggles and/or full-face shield where dusting or splashing of solutions is possible. Maintain eye wash fountain and quick-drench facilities in work area.
Other Control Measures: Maintain good housekeeping in work area. Dust deposits on floors and other surfaces may pick up moisture and cause the surfaces to become slippery and present safety hazards. Handle in accordance with good industrial hygiene and safety practice.
Section 9: Physical and Chemical Properties
Physical state and appearance: White to light-yellow powder.
Odor: Odorless.
Odor threshold: Not available.
pH: 5 to 8.
Relative density: Not available.
Melting point/freezing point: Not available.
Initial boiling point and boiling range: Not available.
Flash point: Not available.
Auto-ignition temperature: Not available.
Decomposition temperature: Not available.
Upper/lower flammability or explosive limits: Not available.
Vapor pressure: Not available.
Vapor density: Not available.
Evaporation rate: Not available.
Flammability (solid, gas): Not available.
Partition coefficient: n-octanol/water: Not available.
Solubility: Practically insoluble in water. Soluble in methanol.
Viscosity: As per label.
Section 10: Stability and Reactivity Data
Stability: It is stable in room temperature in closed containers under normal storage & handling.
Conditions of instability: Incompatible materials, Strong oxidizers. May react vigorously with bleaching powder, Fluorine, Nitric acid.
Incompatibility with various substances: Avoid high temperatures, sparks, open flames, and moisture. Avoid contact with strong oxidizing agents.
Polymerization: Will not occur.
Section 11: Toxicological Information
LD50 Oral - Rat: No data available.
Carcinogenic Effects: Not a reported carcinogen by IARC, NTP, ACGIH, OSHA.
Reproductive toxicity: No data available.
Teratogenicity: No data available.
Developmental Effects: No data available.
Section 12: Ecological Information
Toxicity to fish: No data available.
Persistence and Degradability: Soluble in water and hence may not persist.
Bioaccumulation/ Accumulation: No information available.
Mobility: Is likely mobile in the environment due its water solubility.
Section 13: Disposal Considerations
Waste Disposal: Waste must be disposed of in accordance with federal, state, and local environmental control regulations.
Section 14: Transport Information
DOT USA, TDG Canada & ADR/RID Europe: Not dangerous goods.
IMDG: Not dangerous goods.
IATA: Not dangerous goods.
Section 15: Other Regulatory Information
USA Regulations:
SARA 311/312 Hazard Categories: Not applicable. See section 2.
California Prop 65: California No Significant Risk Level: None of the chemicals in this product are listed.
Section 16 - Additional Information
DISCLAIMER: The information and recommendations set forth herein (hereinafter "Information") are presented in good faith and believed correct as of the date hereof. It is compiled from various sources, and it is not necessarily all inclusive nor fully adequate in every circumstance. In addition, these suggestions should not be confused with nor followed in violation of applicable laws, regulations, rules, or insurance requirements applicable. This MSDS sheet is intended only as a guide to the appropriate precautionary handling of the material by a professionally trained person using this product. Individuals receiving the information must exercise their independent judgment in determining its appropriateness for a particular purpose.
HPMCAS or Hypromellose Acetate Succinate or Hydroxypropyl Methyl Cellulose Acetate Succinate Manufacturers, Suppliers, Exporters, Wholesalers:
King of Chemicals manufacturers
Plot No. 2900/46&47 + 2900/163to167, GIDC, Ankleshwar, Dist. Bharuch, India
India, USA, UAE
TEL: (Office) 91-22-23774610, 91-22-23723564
e-mail: info@kingofchemicals.com
Copyright and Usual Disclaimer is Applicable --- October 28, 2024
If I give you “My Word” Nobody can undo it.
If I sign an “Agreement” my Lawyer will undo it
Our products are for industrial and laboratory use only. The user must test the material before use. We are not dispensing chemists or druggist and do not offer over the counter type (OTC) products for medical use by individuals.
We and our associates manufacture pure chemicals surpassing Monograph Specifications of Analytical Reagent Standards, British & European Pharmacopoeia BP Ph Eur EP Standard, US Pharmacopoeia USP NF Standard, Indian Pharmacopoeia IP Standard, Japan Pharmacopoeia JP Standard, FCC Food Grade Standard. |
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