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King of Chemicals Manufacturers Diazepam and API BP Ph Eur EP USP NF IP JP ChP PPRC Reagent FCC Food Grade Manufacturer |
Specifications, Properties, Uses, SDS of Diazepam API USP BP Ph Eur EP Grade Analytical Reagent FCC Food Grade Manufacturer Supplier Exporter Wholesale & Small Packs, CAS Number 439-14-5. | |
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Muby Chem Pvt. Ltd. is a several decades old group of companies, engaged in manufacturing, supplying, distributing, wholesale supplies of Diazepam USP BP Ph Eur EP Grade for actual users, including retail or small pack supplies for research and development work.
We supply fine and speciality chemicals, pharmaceutical excipients, mineral fortifiers in chemically pure, analytical reagent grade, API IP BP USP Ph Eur EP JP ChP PPRC and other pharmaceutical grade monograph including FCC Food grade chemicals and Nutraceuticals at best prices. We and/or our associated units have all the facilities to supply as per cGMP standard observing good manufacturing practice and good laboratory practice. We can assure low microbial count and also offer a test certificate for the same. We maintain warehouses across USA, India, and UAE. Our group exports to USA, Canada, Mexico, Argentina, Brazil, Chile, Korea, Malaysia, Thailand, Indonesia, Europe, and several other parts of the world. We supply in wholesale container loads to small pack of few grams. Solid products may be specified for it size and shape as desired by the buyer.
Diazepam CAS Number 439-14-5
For Properties Specifications Uses of Diazepam Click Properties, Specifications, Uses, Price, Process of Diazepam Manufacturer.
For For SDS MSDS Sheet of Diazepam Click SDS Safety Data Sheet MSDS Sheet of Diazepam Manufacturer.
The Properties, Specifications, Monograph and Uses of Diazepam :
Diazepam calms the central nervous system by enhancing the effects of gamma-aminobutyric acid (GABA), a natural chemical that reduces nerve activity in the brain. It is used in medecine for treatment of Anxiety and Panic, Seizures and Epilepsy, Muscle Spasms, Alcohol Withdrawal, etc.
Diazepam BP Ph Eur Grade:
C16H13ClN2O --- 284.7 CAS 439-14-5
Action and use: Benzodiazepine.
DEFINITION
7-Chloro-1-methyl-5-phenyl-1,3-dihydro-2H-1,4-benzodiazepin-2-one.
Content: 99.0 per cent to 101.0 per cent (dried substance).
CHARACTERS
Appearance: White or almost white, crystalline powder.
Solubility: Very slightly soluble in water, soluble in ethanol (96 per cent).
IDENTIFICATION
Infrared absorption spectrophotometry.
TESTS
Related substances: To pass the test by Liquid chromatography.
Loss on drying: Maximum 0.5 per cent, determined on 1.000 g by drying in vacuo at 60C for 4 h.
Sulfated ash: Maximum 0.1 per cent, determined on 1.0 g.
Storage: Protected from light.
Diazepam USP Grade Specifications:
C16H13ClN2O --- 284.74
2H -1,4-Benzodiazepin-2-one, 7-chloro-1,3-dihydro-1-methyl-5-phenyl-.
7-Chloro-1,3-dihydro-1-methyl-5-phenyl-2H -1,4-benzodiazepin-2-one
CAS 439-14-5
UNII: Q3JTX2Q7TU
Diazepam contains not less than 95.0 percent and not more than 105.0 percent of C16H13ClN2O, calculated on the dried basis.
Packaging and storage: Preserve in tight, light-resistant containers.
Identification:
A. Infrared Absorption.
B. Thin-Layer Chromatography.
Melting range: between 131C and 135C.
Loss on drying: Dry it in vacuum over phosphorus pentoxide at 60C for 4 hours: it loses not more than 0.5% of its weight.
Residue on ignition: not more than 0.1%.
Related compounds: To pass the test by chromatography.
Diazepam EP Grade is also manufactured.
The MSDS-SDS Hazard Statement of Diazepam :
Diazepam SDS, Safety Data Sheet
MSDS, Material Safety Data Sheet
1. Product Identification
Product Name & Other Names: Diazepam.
CAS No.: 439-14-5
EINECS Number: 207-122-5
Molecular Weight: 284.74
Chemical Formula: C16H13ClN2O
Relevant uses and uses advised against (if any): Laboratory Chemicals and Industrial Use only.
Supplier: As per letterhead.
2. Hazards Identification
GHS, Globally Harmonized System Classification in accordance with 29 CFR 1910
Classification according to Regulation (EC) No 1272/2008
Acute oral toxicity Category 3 H301
Acute toxicity, Dermal (Category 3) H311
Labeling according to GHS & Regulation (EC) No 1272/2008
GHS Label Elements Toxic |
Signal Word: Danger
Hazard statements:
H301+H311: Toxic if swallowed and in contact with skin.
Precautionary statements:
P202: Do not handle until all safety precautions have been read and understood.
P260: Do not breathe dust/fume/gas/mist/vapors/spray.
P264: Wash … thoroughly after handling.
P270: Do not eat, drink, or smoke when using this product.
P271: Use only outdoors or in a well-ventilated area.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P330: Rinse mouth.
P301+312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell.
P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a comfortable position for breathing.
P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P332+313: If skin irritation occurs: Get medical advice/attention.
P337+313: If eye irritation persists get medical advice/attention.
3. Composition/Information on Ingredients
Product Name & Other Names: Diazepam.
CAS No.: 439-14-5
EINECS Number: 207-122-5
4. First Aid Measures
Always seek medical attention after first aid measures are provided.
Inhalation: If inhaled, remove to fresh air. If breathing is difficult, give oxygen. Get medical attention.
Ingestion: Give large amounts of water to drink. Never give anything by mouth to an unconscious person. Get medical attention.
Skin Contact: In case of contact, immediately flush skin with plenty of water. Cover the irritated skin with an emollient. Remove contaminated clothing and shoes. Cold water may be used. Wash clothing & Shoes before reuse. Get medical attention.
Eye Contact: Check for and remove any contact lenses. In case of contact, immediately flush your eyes with plenty of water for at least 15 minutes. Cold water may be used. Get medical attention.
Notes to Physician: Treat symptomatically.
5. Fire Fighting Measures
Fire: Not combustible, however, it can burn at high temperature. Decomposes on heating emitting toxic fumes.
Fire Extinguishing Media: Use water spray, alcohol-resistant foam, dry chemical, or carbon dioxide. Use means suitable for extinguishing surrounding fire. Avoid heavy water stream. Cool containers with water spray until well after the fire is out. Avoid getting water inside containers.
Decomposition Products: Fumes, carbon oxides, hydrogen chloride, chlorine along with nitrogen oxides.
Special Information: In the event of a fire, wear full protective clothing and NIOSH-approved self-contained breathing apparatus with full face piece operated in the pressure demand or other positive pressure mode. At high temperatures under fire conditions, it may produce toxic or irritating fumes.
6. Accidental Release Measures
Personal precautions, protective equipment, and emergency procedures: Avoid breathing dust/fumes/gas/mist/vapors/spray. Use individual protective equipment (waterproof boots, suitable protective clothing, safety glasses, etc.).
Environmental precautions: Do not let the product enter drains, soil, or water sources.
Methods and materials used for containment cleanup procedures and Storage: Wear respiratory protection. Avoid breathing vapors, mist, or gas. Ensure adequate ventilation. Keep people away from upwind of spill/leak. Evacuate personnel to safe areas. Pick up and arrange disposal without creating dust. Contain spilled material. Cover with an inert, non-combustible absorbent material, (e.g., sand, earth, diatomaceous earth, vermiculite). Use a shovel to put the material into a convenient waste disposal container.
7. Handling and Storage
Do not breathe vapor/dust/mist. Do not get in eyes, on skin, or on clothing. Avoid dust formation. Do not ingest.
Precautions for safe handling: Apply according to good manufacturing and industrial hygiene practices. Ensure proper ventilation. In case of insufficient ventilation, wear suitable respiratory equipment. Wash thoroughly after handling it. Do not drink, eat, or smoke while handling. Avoid contact with skin, eyes, and clothing. Minimize dust generation. Avoid breathing dust/fumes/gas/mist/vapors/spray. Keep container tightly closed. Avoid ingestion and inhalation. Use individual protective equipment (waterproof boots, suitable protective clothing, safety glasses, etc.). Prevent any contact with hot surfaces.
Conditions for safe storage, including any incompatibilities: Store in cool, dry, and ventilated area away from heat sources and protected from sunlight in tightly closed original container. Keep air contact to a minimum. Store protected from heat, sparks and ignition sources and incompatible materials. Avoid inhalation of dust/mist/vapor. Do not store with incompatible materials like strong oxidizing agents, acid, and bases. Storage: Preserve in tight, light-resistant containers.
8. Exposure Controls/Personal Protection
Airborne Exposure Limits: Not established by any regulating body.
Engineering Controls: Showers, Eyewash stations, Ventilation systems.
Ventilation System: A system of local and/or general exhaust is recommended to keep employee exposures as low as possible.
Personal Respirators (NIOSH Approved): For conditions of use where exposure to dust or mist is apparent and engineering controls are not feasible, a particulate respirator may be worn.
Skin Protection: Wear protective gloves and clean body-covering clothing.
Eye Protection: Use chemical safety goggles and/or full-face shield where dusting or splashing of solutions is possible. Maintain eye wash fountain and quick-drench facilities in work area.
Other Control Measures: Maintain good housekeeping in work area. Handle in accordance with good industrial hygiene and safety practice.
9. Physical and Chemical Properties
Appearance: White to light yellow crystalline powder.
Odor: Odorless.
Odor threshold: Not applicable.
pH: No data found.
Relative density: No data found.
Melting Point: 131C to 135C literature. 125C to 126C is also reported.
Initial boiling point and boiling range: No data found.
Flash point: No data found.
Auto-ignition temperature: No data found.
Decomposition temperature: No data found.
Upper/lower flammability or explosive limits: No data found.
Vapor pressure: No data found.
Vapor density: No data found.
Evaporation rate: No data found.
Flammability (solid, gas): No data found.
Partition coefficient: n-octanol/water: No data found.
Solubility: Very slightly soluble in water. Soluble in ethanol (96%), DMF, benzene, acetone.
Viscosity: No data found.
10. Stability and Reactivity
Stability: Stable under ordinary conditions of use and storage.
Hazardous Decomposition Products: Fumes, carbon oxides, hydrogen chloride along with nitrogen oxides may be released.
Hazardous Polymerization: Will not occur.
Incompatibilities: Strong oxidants, acid, and bases.
Conditions to Avoid: Heat, Direct sunlight, Moisture, and Incompatibles. Contact with strong acids liberates hydrogen chloride. Always avoid Strong acids, Strong alkalis, Oxidizing agents.
11. Toxicological Information
Acute toxicity: Toxic in contact with skin. Toxic if swallowed.
Acute toxicity estimates Oral - 249 mg/kg. Acute toxicity estimates Dermal - 800 mg/kg.
LD50/oral/rat = 249 mg/kg.
Carcinogenicity: Not classifiable as to its carcinogenicity to humans by IARC, ACGIH, NTP, or EPA.
Reproductive toxicity: No data found.
Developmental Effects: No data found.
Teratogenicity: No data found.
12. Ecological Information
Toxicity to fish: No data found.
Persistence and Degradability: No data found.
Mobility: No data found.
Results of PBT and vPvB assessment: No data found.
13. Disposal Considerations
Whatever cannot be saved for recovery, or recycling should be managed in an appropriate and approved waste disposal facility. Follow all the pollution control rules.
14. Transport Information
DOT USA, TDG Canada & ADR/RID Europe:
UN number: 2811, Class: 6.1, Packing group: III.
Proper shipping name: Toxic solid, organic, n.o.s. (Diazepam).
IMDG/IMO & IATA/ICAO:
UN number: 2811, Class: 6.1, Packing group: III.
Proper shipping name: Toxic solid, organic, n.o.s. (Diazepam).
15. Regulatory Information
USA:
SARA 311/312 Hazard Categories: See section 2.
California Proposition 65: Not listed.
Section 16 - Additional Information
Disclaimer:
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Our company provides this MSDS sheet in good faith but makes no representation as to its comprehensiveness or accuracy. This SDS sheet is intended only as a guide to the appropriate precautionary handling of the material by a properly trained person using this product. The above information has been compiled from various sources and has the possibility of discrepancy and being out-dated information. Individuals receiving the information must exercise their independent judgment and do further search in determining its appropriateness for a particular purpose. In no case shall our company be liable to loss or damages by the product user.
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Diazepam Manufacturers, Suppliers, Exporters, Wholesalers:
King of Chemicals manufacturers
Plot No. 2900/46&47 + 2900/163to167, GIDC, Ankleshwar, Dist. Bharuch, India
India, USA, UAE
TEL: (Office) 91-22-65290111
email: info@kingofchemicals.com
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Our products are for industrial and laboratory use only. The user must test the material before use. We are not despensing chemists or druggist and do not offer over the counter type (OTC) products for medical use by individuals.
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