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Specifications, Properties, Uses, SDS of Disodium EDTA or Edetate Disodium USP BP Ph Eur FCC Food Grade Manufacturer Supplier Exporter Wholesale & Small Packs, CAS Number 6381-92-6 & 139-33-3.

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Disodium EDTA or Edetate Disodium Manufacturer Supplier Exporter
Disodium EDTA or Edetate Disodium CAS Number 6381-92-6 & 139-33-3

For Properties Specifications Uses of Disodium EDTA or Edetate Disodium Click Properties, Specifications, Uses, Price, Process of Disodium EDTA or Edetate Disodium Manufacturer.

For For SDS MSDS Sheet of Disodium EDTA or Edetate Disodium Click SDS Safety Data Sheet MSDS Sheet of Disodium EDTA or Edetate Disodium Manufacturer.

The Properties, Specifications, Monograph and Uses of Disodium EDTA or Edetate Disodium:

CAS Number 6381-92-6 & 139-33-3, EINECS EC Number 205-358-3, HS code 29212100 or 29224990, Molecular Weight 372.2, Chemical Formula C10H14N2O8-2H2O

Disodium EDTA or Edetate Disodium is a chelating agent that sequesters a variety of polyvalent cations. It is used in pharmaceutical manufacturing and as a food additive. Disodium EDTA is a preservative, sequestrant, and stabilizer.

Edetate Disodium USP Grade Specifications:
C10H14N2Na2O8-2H2O --- 372.24
C10H14N2Na2O8 --- 336.21
Glycine, N,N -1,2-ethanediylbis[N-(carboxymethyl)-, disodium salt, dihydrate;
Disodium (ethylenedinitrilo)tetraacetate dihydrate --- CAS 6381-92-6
Anhydrous --- CAS 139-33-3

DEFINITION
Edetate Disodium contains NLT 99.0% and NMT 101.0% of edetate disodium (C10H14N2Na2O8), calculated on the dried basis.

IDENTIFICATION
A. Infrared Absorption
B.
Sample: 50 mg
Analysis: To 5 mL of water in a test tube add 2 drops of ammonium thiocyanate and 2 drops of ferric chloride. To the deep red solution add the Sample.
Acceptance criteria: The red color is discharged, leaving a yellowish solution.
C. Identification Tests-General, Sodium: It meets the requirements of the pyroantimonate precipitation test.

ASSAY
Procedure
Sample solution: Dissolve 5 g of Edetate Disodium in about 100 mL of water contained in a 250-mL volumetric flask. Add water to volume.
Analysis: Place 200 mg of chelometric standard calcium carbonate, previously dried at 110C for 2 h and cooled in a desiccator, into a 400-mL beaker. Add 10 mL of water, and swirl to form a slurry. Cover the beaker with a watch glass, and without removing the latter, add 2 mL of 3 N hydrochloric acid from a pipet. Swirl the contents of the beaker and dissolve the calcium carbonate. With water, wash down the sides of the beaker, the outer surface of the pipet, and the watch glass, and dilute with water to 100 mL. While stirring the solution, preferably with a magnetic stirrer, add 30 mL of the Sample solution from a 50-mL buret. Add 15 mL of 1 N sodium hydroxide and 0.30 g of hydroxy naphthol blue and continue the titration with the Sample solution to a blue endpoint.

Calculate the weight of edetate disodium (C10H14N2Na2O8) in the portion of Edetate Disodium taken:
Result = (VT/VU) x W x (Mr1/Mr2)

VT = total volume of theSample solution(mL)
VU = volume of theSample solutionconsumed in the titration (mL)
W = weight of calcium carbonate (mg)
Mr1 = molecular weight of edetate disodium, 336.21
Mr2= molecular weight of calcium carbonate, 100.09
Acceptance criteria: 99.0% to 101.0% on the dried basis

Calcium:
Sample solution: 1 g of Edetate Disodium in 20 mL of water
Analysis: To the Sample solution add 2 drops of methyl red and neutralize with 6 N ammonium hydroxide. Add 3 N hydrochloric acid dropwise until the solution is just acidic, and then add 1 mL of ammonium oxalate.
Acceptance criteria: No precipitate is formed.
Limit of Nitrilotriacetic Acid: To pass the test by Chromatography.
pH:
Sample solution: 50 mg/mL
Acceptance criteria: 4.0 to 6.0
Loss on Drying:
Analysis: Dry at 150C for 6 h.
Acceptance criteria: 8.7% to 11.4%
Packaging and Storage:Preserve in well-closed containers.

Disodium Edetate BP Ph Eur Grade Specifications
C10H14N2Na2O8-2H2O -- 372.2 -- CAS 139-33-3

DEFINITION
Disodium dihydrogen (ethylenedinitrilo)tetraacetate dihydrate.
Content: 98.5 per cent to 101.0 per cent.

CHARACTERS
Appearance: White or almost white, crystalline powder.
Solubility: Soluble in water, practically insoluble in ethanol (96 per cent).

IDENTIFICATION
First identification A, B, D.
Second identification B, C, D.
A. Infrared absorption spectrophotometry.
B. Dissolve 2 g in 25 ml of water, add 6 ml of lead nitrate solution, shake and add 3 ml of potassium iodide solution. No yellow precipitate is formed. Make alkaline to red litmus paper by the addition of dilute ammonia. Add 3 ml of ammonium oxalate solution R. No precipitate is formed.
C. Dissolve 0.5 g in 10 ml of water and add 0.5 ml of calcium chloride solution. Make alkaline to red litmus paper by the addition of dilute ammonia and add 3 ml of ammonium oxalate solution. No precipitate is formed.
D. It gives the reactions of sodium.

TESTS
Solution S: Dissolve 5.0 g in carbon dioxide-free water and dilute to 100 ml with the same solvent.
Appearance of solution: Solution S is clear and colourless.
pH: 4.0 to 5.5 for solution S.
Impurity A: Liquid chromatography. Carry out the test protected from light.
To pass the test
Limit: impurity A: not more than the area of the corresponding peak in the chromatogram obtained with the reference solution (0.1 per cent).
Iron: Maximum 80 ppm.
Heavy metals: Maximum 20 ppm

IMPURITIES
Specified impurities A
A. nitrilotriacetic acid.


Specifications of Disodium EDTA FCC Food Grade
Disodium Ethylenediaminetetraacetate; Disodium (Ethylenedinitrilo)tetraacetate; Disodium Edetate
C10H14N2Na2O8-2H2O Formula wt 372.24
INS: 386 CAS: [CAS 6381-92-6]

DESCRIPTION
EDTA Disodium occurs as a white, crystalline powder. It is soluble in water.

REQUIREMENTS
Identification
A. A 1:20 aqueous solution responds to the flame test for Sodium.
B. Add 2 drops of ammonium thiocyanate TS and 2 drops of ferric chloride TS to 5 mL of water in a test tube. Add about 50 mg of sample to the deep red solution so obtained, and mix. The deep red color disappears.
C. The infrared absorption spectrum of a potassium bromide dispersion of sample exhibits relative maxima at the same wavelengths as those of a similar preparation of USP Edetate Disodium Reference Standard.

Assay: Not less than 99.0% and not more than 101.0% of C10H14N2Na2O8-2H2O.
Calcium: Negative.
Lead: Not more than 10 mg/kg.
Nitrilotriacetic Acid: Not more than 0.1%.
pH of a 1:100 Solution: Between 4.3 and 4.7.


The MSDS-SDS Hazard Statement of Disodium EDTA or Edetate Disodium:

Disodium EDTA SDS, Safety Data Sheet
Disodium Edetate, Ethylenediaminetetraacetic Acid Disodium Salt MSDS, Material Safety Data Sheet
21-Aug-21

1. Product Identification

Product Name & Other Names: Disodium EDTA or Disodium Edetate or Ethylenediaminetetraacetic Acid Disodium Salt.
Synonyms: (Ethylenedinitrilo) tetra acetic acid disodium salt; disodium dihydrogen ethylenediaminetetraacetate; N,N'-1,2-ethanediylbis [N-(carboxymethyl)- glycine], disodium salt, dihydrate; Edetate disodium.
CAS No.:
139-33-3 (Anhydrous); 6381-92-6 (Dihydrate)
EC EINECS No. 205-358-3
Molecular Weight: 372.24 Dihydrate
Chemical Formula: C10H14O8N2Na2-2H2O Dihydrate
Relevant uses and uses advised against (if any): Industrial use only.
Supplier
: As per letterhead.

2. Hazards Identification

GHS, Globally Harmonized System Classification in accordance with 29 CFR 1910
Classification according to Regulation (EC) No 1272/2008

Acute Toxicity - Oral Category 5, H303
Skin corrosion/irritation Category 2, H315
Serious eye damage/eye irritation Category 2B, H320
Specific target organ toxicity - single exposure, respiration Category 3, H335

Labeling according to GHS & Regulation (EC) No 1272/2008

GHS Label Elements
Irritant
Irritant

Signal Words: Warning

Hazard statements:
H303: May be harmful if swallowed.
H315: Causes skin irritation.
H320: Causes eye irritation.
H335: May cause respiratory irritation.

Precautionary statements:
P262: Do not get in eyes, on skin, or on clothing.
P264: Wash skin thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
P302+P352-IF ON SKIN: Wash with plenty of soap and water.
P332+313: If skin irritation occurs: Get medical advice/attention.
P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305+351+338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do – continue rinsing.
P337+P313: If eye irritation persists: Get medical advice/ attention.
P362: Take off contaminated clothing and wash before reuse.

3. Composition/Information on Ingredients

Product Name & Other Names: Disodium EDTA or Disodium Edetate or Ethylenediaminetetraacetic Acid Disodium Salt.
CAS No.: 6381-92-6 (Dihydrate)
EC EINECS No. 205-358-3

4. First Aid Measures

Always seek medical advice after the first aid treatment.

Inhalation: If inhaled, remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical attention.
Ingestion: Do NOT induce vomiting unless directed to do so by medical personnel. Never give anything by mouth to an unconscious person. Loosen tight clothing such as a collar, tie, belt, or waistband. Get medical.
Skin Contact: Immediately flush skin with plenty of water for at least 15 minutes. Remove contaminated clothing and shoes. Wash clothing before reuse. Thoroughly clean shoes before reuse. Get medical attention if irritation develops.
Eye Contact: Immediately flush eyes with plenty of water for at least 15 minutes, lifting upper and lower eyelids occasionally. Get medical attention if irritation persists.

5. Fire Fighting Measures

Fire: Not considered to be a fire hazard. It may burn at higher temperatures.
Explosion: Not considered to be an explosion hazard.
Fire Extinguishing Media: Use any means suitable for extinguishing surrounding fire.
Extinguishing Media Not recommended: Avoid using solid water jet as it may scatter the fire.
Special Information: In the event of a fire, wear full protective clothing and NIOSH-approved self-contained breathing apparatus with full face piece operated in the pressure demand or other positive pressure mode. At high temperatures under fire conditions, it may produce toxic or irritating fumes. Fire-extinguishing work is done from the windward and the suitable fire-extinguishing method according to the surrounding situation is used. Uninvolved persons should evacuate to a safe place.

6. Accidental Release Measures

Personal precautions, protective equipment, and emergency procedures: Avoid breathing dust/fumes/gas/mist/vapors/spray. Use individual protective equipment (waterproof boots, suitable protective clothing, safety glasses, etc.). Restrict unprotected personnel from the area. Prevent any contact with hot surfaces. Do not approach facing the wind. Do not touch the spilled material.
Environmental precautions: Do not let the product enter drains, soil, or water sources.
Methods and materials used for containment cleanup procedures and Storage: Do not inhale dust, vapors, mist, or gas. Avoid dust formation. Contain spilled material. Cover with an inert, non-combustible absorbent material, (e.g., sand, earth, diatomaceous earth, vermiculite). Use a shovel to put the material into a convenient waste disposal container. Finish cleaning by spreading water on the contaminated surface and allow to evacuate as per law.

7. Handling and Storage

Precautions for safe handling: Apply according to good manufacturing and industrial hygiene practices. Ensure proper ventilation. In case of insufficient ventilation, wear suitable respiratory equipment. Wash thoroughly after handling. Do not drink, eat, or smoke while handling. Avoid contact with skin, eyes, and clothing. Minimize dust generation. Avoid breathing dust/fumes/gas/mist/vapors/spray. Avoid contact with eyes, skin, and clothing. Keep container tightly closed. Avoid ingestion and inhalation. Use individual protective equipment (waterproof boots, suitable protective clothing, safety glasses, etc.). Prevent any contact with hot surfaces.
Conditions for safe storage, including any incompatibilities: Store in cool, dry, and ventilated area away from heat sources and protected from sunlight in tightly closed original container. Keep air contact to a minimum. Store protected from heat, sparks and ignition sources and incompatible materials. Avoid contact with skin and eyes. Avoid inhalation of dust/mist/vapor. Do not store with incompatible materials like strong oxidizing agents and metals.

8. Exposure Controls/Personal Protection

Airborne Exposure Limits: None established.
Ventilation System: A system of local and/or general exhaust is recommended to keep employee exposures as low as possible. Local exhaust ventilation is generally preferred because it can control the emissions of the contaminant at its source, preventing dispersion of it into work area.
Personal Respirators (NIOSH Approved): For conditions of use where exposure to dust or mist is apparent and engineering controls are not feasible, a particulate respirator (NIOSH type N95 or better filters) may be worn. If oil particles (e.g., lubricants, cutting fluids, glycerin, etc.) are present, use a NIOSH type R or P filter. For emergencies or instances where the exposure levels are not known, use a full-face positive-pressure, air-supplied respirator.
Skin Protection: Wear protective gloves and clean body-covering clothing.
Eye Protection: Use chemical safety goggles. Maintain eye wash fountain and quick-drench facilities in work area.
Other Control Measures: Maintain good housekeeping in work area. Dust deposits on floors and other surfaces may pick up moisture and cause the surfaces to become slippery and present safety hazards. Handle in accordance with good industrial hygiene and safety practice.

9. Physical and Chemical Properties

Appearance: White crystals.
Odor: Odorless.
Odor threshold: Not available.
pH: Not available.
Relative density: Not available.
Melting Point: 252C (486F) Decomposes.
Initial boiling point and boiling range: Not available.
Flash point: Not available.
Auto-ignition temperature: Not available.
Decomposition temperature: Not available.
Upper/lower flammability or explosive limits: Not available.
Vapor pressure: Not available.
Vapor density: Not available.
Evaporation rate: Not available.
Flammability (solid, gas): Not available.
Partition coefficient: n-octanol/water: Not available.
Solubility: 10 g in 100 g of water.
Viscosity: Not available.
Molecular Weight: 372.24 Dihydrate
Chemical Formula: C10H14O8N2Na2.2H2O Dihydrate.

10. Stability and Reactivity

Stability: Stable under ordinary conditions of use and storage.
Hazardous Decomposition Products: Burning may produce carbon monoxide, carbon dioxide, nitrogen oxides.
Hazardous Polymerization: Will not occur.
Incompatibilities: Oxidizing agents and Metals.
Conditions to Avoid: Incompatibles.

11. Toxicological Information

Anhydrous: Oral rat LD50: 2000 mg/kg. Investigated as a mutagen, reproductive effector. Hydrate: Investigated as a mutagen.
Carcinogenic Effects: Not a reported carcinogen by IARC NTP ACGIH OSHA.
Mutagenic Effects: Animal studies show it as mutagen.
Teratogenic Effects: Not available.
Developmental Toxicity: Not available.

12. Ecological Information

Toxicity to fish LC50: Leuciscus idus (Golden orfe) - > 500 mg/l - 96h.
Toxicity to daphnia & other aquatic invertebrates: EC50 - Daphnia - > 100 mg/l - 24h.
Persistence and Degradability: No information available.
Mobility: No information available.
Bioaccumulation/ Accumulation: No information available.
Results of PBT and vPvB assessment: No data available for assessment.

13. Disposal Considerations

Whatever cannot be saved for recovery or recycling should be managed in an appropriate and approved waste disposal facility. Processing use or contamination of this product may change the waste management options. State and local disposal regulations may differ from federal disposal regulations. Dispose of container and unused contents in accordance with legal requirements.

14. Transport Information

Land Transport DOT USA, TDG Canada & ADR/RID Europe: Not regulated.
Air transport IATA/ICAO & Sea Transport IMDG/IMO: Not regulated.

15. Regulatory Information

USA:
SARA 311/312 Hazards
: Acute.
California Prop 65: Not listed.

Section 16 - Additional Information

DISCLAIMER: The information and recommendations set forth herein are presented in good faith and believed correct as of the date hereof. It is compiled from various sources, and it is not necessarily all inclusive nor fully adequate in every circumstance. In addition, these suggestions should not be confused with nor followed in violation of applicable laws, regulations, rules, or insurance requirements applicable. This SDS MSDS sheet is intended only as a guide to the appropriate precautionary handling of the material by a professionally trained person using this product. Individuals receiving the information must exercise their independent judgment in determining its appropriateness for a particular purpose. This shall not constitute a guarantee for any specific product features and shall not establish a legally valid contractual relationship. In no case shall our company be liable to loss or damages by the product user.

Muby Chem P Ltd

Disodium EDTA or Edetate Disodium Manufacturers, Suppliers, Exporters, Wholesalers:

King of Chemicals manufacturers

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Plot No. 2900/46&47 + 2900/163to167, GIDC, Ankleshwar, Dist. Bharuch, India
India, USA, UAE
TEL: (Office) 91-22-23774610, 91-22-23723564

e-mail: info@kingofchemicals.com

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