Specifications, Uses, SDS of Poloxamer Manufacturers

	King of Chemicals Manufacturers
Specifications, Properties, Uses, SDS of Poloxamer 124, 188, 237, 331, 338, 407 USP NF BP Ph Eur FCC Food Grade Manufacturer Supplier Exporter Wholesale & Small Packs, CAS Number 9003-11-6.
King of Chemicals has several associated companies having accreditations like cGMP, GLP - FDA Approved Good Manufacturing Practice and Good Laboratory Practice of WHO standard, ISO-9001, ISO-14001, ISO/IEC 17025, ISO ISO-45000, HACCP, FSSC 220000, FSSAI, "REACH" Registered, Kosher & Halal Certified. e-CTD and DMF support can be made available if needed. We offer USP NF BP Ph Eur EP IP JP Analytical Reagent FCC Food Grade Chemicals & Nutraceuticals.

Muby Chem Pvt. Ltd. is a several decades old group of companies, engaged in manufacturing, supplying, distributing, wholesale supplies of Poloxamer for actual users, including retail or small pack supplies for research and development work.

We supply fine and speciality chemicals, pharmaceutical excipients, mineral fortifiers in chemically pure, analytical reagent grade, IP BP USP Ph Eur EP JP and other pharmaceutical grade monograph including FCC Food grade chemicals and Nutraceuticals at best prices. We and/or our associated units have all the facilities to supply as per cGMP standard observing good manufacturing practice and good laboratory practice. We can assure low microbial count and also offer a test certificate for the same. We maintain warehouses across USA, India, and UAE. Our group exports to USA, Canada, Mexico, Argentina, Brazil, Chile, Korea, Malaysia, Thailand, Indonesia, Europe, and several other parts of the world. We supply in wholesale container loads to small pack of few grams. Solid products may be specified for it size and shape as desired by the buyer.

Poloxamer 407 is used to increase the viscosity of topical aqueous formulations, as a thickening agent and gel former, as well as co-emulsifier and consistency enhancer in creams and liquid emulsions. Poloxamer 407 functions as an emulsifier in mouthwash formulations, providing cleaning and solubilization functions without creating too much foam or as a thickener in toothpaste. These polymers are commonly used in industrial applications, cosmetics, and pharmaceuticals.

Specifications of Poloxamer USP NG Grade:
HO(C2H4O)a(C3H6O)b(C2H4O)aH
Polyethylene-polypropylene glycol --- CAS Number 9003-11-6

DEFINITION
Poloxamer is a synthetic block copolymer of ethylene oxide and propylene oxide. It is available in several types, conforming to the requirements shown in the following table.

IDENTIFICATION
A. Infrared Absorption: Use a thin film of melted specimen if it is a solid. Use USP Poloxamer Liquid for Poloxamer 124, and use USP Poloxamer Solid for Poloxamer 188, 237, 338, and 407. Because of the differences in the ratios of copolymer composition, the intensity of some absorption bands may vary.

ASSAY
Average Molecular Weight:
To pass the test.
Acceptance criteria: See the table in the Definition.
Weight Percent Oxyethylene:
To pass the test.
Acceptance criteria: See the table in the Definition.
Unsaturation:
To pass the test.
Acceptance criteria: See the table in the Definition.
Limit of Free Ethylene Oxide, Propylene Oxide, and 1,4-Dioxane:
To pass the test by Chromatography.
Acceptance criteria:
Ethylene oxide: NMT 1 micro-g/g
Propylene oxide: NMT 5 micro-g/g
1,4-Dioxane: NMT 5 micro-g/g

pH: 5.0–7.5, in a solution (1 in 40)
Packaging and Storage: Preserve in tight containers. No storage requirements specified.
Labeling: Label it to state, as part of the official title, the Poloxamer number. Label it to indicate the name and quantity of any antioxidant.

Specifications of Poloxamers BP Ph Eur Grade:
Action and use: Non-ionic surfactant.

DEFINITION
Synthetic block copolymer of ethylene oxide and propylene oxide.
A suitable antioxidant may be added.

CHARACTERS
Appearance:
-poloxamer 124: colourless or almost colourless liquid;
-poloxamers 188, 237, 338, 407: white or almost white, waxy powder, microbeads or flakes.
Solubility:
-poloxamers 124, 237, 338, 407: very soluble in water and in ethanol (96 per cent), practically insoluble in light petroleum (bp: 50-70C);
-poloxamer 188: soluble in water and in ethanol (96 per cent).
mp: About 50C for poloxamers 188, 237, 338 and 407.

IDENTIFICATION
First identification: A, B.
Second identification: B, C.
A. Infrared absorption spectrophotometry.
Comparison Chemical reference substance of the Ph. Eur. corresponding to the type of poloxamer to be examined.
B. Average relative molecular mass (see Tests).
C. Oxypropylene:oxyethylene ratio (see Tests).

TESTS
Solution S: Dissolve 10.0 g in carbon dioxide-free water and dilute to 100 mL with the same solvent.
Appearance of solution: Solution S is not more intensely coloured than reference solution.
pH: 5.0 to 7.5 for solution S.
Ethylene oxide, propylene oxide and dioxan:
To pass the test by Chromatography.
Limits:
-ethylene oxide: not more than 0.5 times the area of the corresponding peak in the chromatogram obtained with the reference solution (1 ppm);
-propylene oxide: not more than 0.5 times the area of the corresponding peak in the chromatogram obtained with the reference solution (5 ppm);
-dioxan: not more than 0.5 times the area of the corresponding peak in the chromatogram obtained with the reference solution (10 ppm).
Average relative molecular mass:
To pass the test.
Oxypropylene:oxyethylene ratio:
To pass the test.
Water: Maximum 1.0 per cent, determined on 1.000 g.
Total ash: Maximum 0.4 per cent, determined on 1.0 g.

Specifications of Poloxamer 407 FCC Food Grade:
αHydro-omega-hydroxy-poly(oxyethylene)-poly(oxypropylene)(63-71 moles)poly(oxyethylene) Block Copolymer
Formula weight: (average) 12,500

DESCRIPTION
Poloxamer 407 occurs as a white solid. It is a copolymer condensate of ethylene oxide and propylene oxide with a melting range of about 52C to 56C. It is freely soluble in alcohol and in water but is insoluble in propylene glycol and in ethylene glycol.
Function: Solubilizing and stabilizing agent in flavor concentrates.

REQUIREMENTS
Cloud Point of a 1:10 Solution: Above 100C.
Ethylene Oxide, Propylene Oxide, and 1,4-Dioxane: Not more than 5 mg/kg of each.
Hydroxyl Value: Between 8.5 and 11.5.
Lead: Not more than 2 mg/kg.
Molecular Weight: Between 9760 and 13,200.
pH of a 2.5% Solution: Between 6.0 and 7.4.

Specifications of Poloxamer 331 FCC Food Grade:
αHydro-omega-hydroxy-poly(oxyethylene)-poly(oxypropylene)(51-57 moles)poly(oxyethylene) Block Copolymer
Formula weight: (average) 3800

DESCRIPTION
Poloxamer 331 occurs as a practically colorless liquid. It is a block copolymer condensate of ethylene oxide and propylene oxide with an average formula weight of 3800, a specific gravity of about 1.02, and a refractive index of about 1.452. It is very slightly soluble in water at 25C but is freely soluble at 0C; it is freely soluble in alcohol but is insoluble in propylene glycol and in ethylene glycol.
Function: Solubilizing and stabilizing agent in flavor concentrates.

REQUIREMENTS
Cloud Point of a 1:10 Solution: Between 9C and 12C.
Ethylene Oxide, Propylene Oxide, and 1,4-Dioxane: Not more than 5 mg/kg of each.
Hydroxyl Value: Between 27.2 and 32.1.
Lead: Not more than 2 mg/kg.
Molecular Weight: Between 3500 and 4125.
pH of a 2.5% Solution: Between 6.0 and 7.4.

Poloxamer 124, 188, 237, 331, 338, 407 SDS, Safety Data Sheet
MSDS Sheet 08-Mar-22

Product Name & Other Names: Poloxamer 124, 188, 237, 331, 338, 407
CAS Number: 9003-11-6
EINECS EC Number: NA
Relevant uses and uses advised against (if any): Industrial Manufacturing.
Suppliers: As per letterhead.

GHS, Globally Harmonized System Classification in accordance with 29 CFR 1910
Classification according to Regulation (EC) No 1272/2008

Not a hazardous substance or mixture according to Regulation (EC) No. 1272/2008.
This substance is not classified as dangerous according to Directive 67/548/EEC.

Precautionary statements:
P261: Avoid breathing dust/fume/gas/mist/vapors/spray.
P262: Do not get in eyes, on skin, or on clothing.
P281: Use personal protective equipment as required.
P302+P352 - IF ON SKIN: Wash with plenty of soap and water.
P304 + P340 - IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338 - IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+313: If eye irritation persists get medical advice/attention.

Product Name & Other Names: Poloxamer 124, 188, 237, 331, 338, 407
CAS Number: 9003-11-6

Emergency and First Aid Procedures:
Eyes - Flush with water for at least 15 minutes, raising and lowering eyelids occasionally. Get medical attention if irritation persists.
Skin - Thoroughly wash exposed area for at least 15 minutes. Remove contaminated clothing. Launder contaminated clothing before reuse. Get medical attention if irritation persists.
Ingestion - If Polyvinyl Acetate is swallowed, if conscious, give plenty of water. Immediately call a physician. Never give anything by mouth to an unconscious person.
Inhalation - Remove to fresh air. Give oxygen if breathing is difficult; give artificial respiration if breathing has stopped. Get medical attention.

Fire: Not a fire hazard but it can burn at high temperature producing oxides of carbon and toxic fumes.
Extinguisher Media: Water spray. Carbon dioxide (CO 2). Dry chemical, alcohol-resistant foam.
Flammable Limits in Air % by Volume: N/A
Extinguishing Media Not recommended: Avoid using solid water jet as it may scatter the fire.
Special Information: In the event of a fire, wear full protective clothing and NIOSH-approved self-contained breathing apparatus with full face piece operated in the pressure demand or other positive pressure mode. At high temperatures under fire conditions, it may produce toxic or irritating fumes. Fire-extinguishing work is done from the windward and the suitable fire-extinguishing method according to the surrounding situation is used. Uninvolved persons should evacuate to a safe place.

Personal precautions, protective equipment, and emergency procedures: Ventilate area of leak or spill. Avoid breathing dust/fumes/gas/mist/vapors/spray. Use individual protective equipment (waterproof boots, suitable protective clothing, safety glasses, etc.). Restrict unprotected personnel from the area. Prevent any contact with hot surfaces. Do not approach facing the wind.
Environmental precautions: Do not let the product enter drains, soil, or water sources.
Methods and materials used for containment cleanup procedures and Storage: Contain spilled material. Cover with an inert, non-combustible absorbent material, (e.g., sand, earth, diatomaceous earth). Vacuum or sweep-up and remove to an approved disposal container.

Precautions for safe handling: Apply according to good manufacturing and industrial hygiene practices. Ensure proper ventilation. Wash thoroughly after handling. Do not drink, eat, or smoke while handling. Avoid contact with skin, eyes, and clothing. Minimize dust generation. Avoid breathing dust/fumes/gas/mist/vapors/spray. Use individual protective equipment (waterproof boots, suitable protective clothing, safety glasses, etc.). Prevent any contact with hot surfaces.
Conditions for safe storage, including any incompatibilities: Keep Polyvinyl Acetate in a well closed container stored under cold to warm conditions, 2 to 40 C, (36 to 104F) in a ventilated area and protected from sunlight. Keep air contact to a minimum. Do not leave the material container open. Store protected from heat, sparks and ignition sources and incompatible materials. Do not store with incompatible materials like strong oxidizing. Protect against physical damage.

Exposure Guidelines: This product does not contain any hazardous materials with occupational exposure limits established by the region-specific regulatory bodies.
Respiratory Protection (Specify Type): None needed under normal conditions of use with adequate ventilation. NIOSH approved equipment should be worn if PELs are exceeded.
Ventilation System: A system of local and/or general exhaust is recommended to keep employee exposures as low as possible.
Personal Respirators (NIOSH Approved): For conditions of use where exposure to dust or mist is apparent and engineering controls are not feasible, a particulate respirator may be worn.
Skin Protection: Wear protective gloves and clean body-covering clothing.
Eye Protection: Use chemical safety goggles and/or full-face shield where dusting or splashing of solutions is possible. Maintain eye wash fountain and quick-drench facilities in work area.
Other Control Measures: Maintain good housekeeping in work area.

Appearance and Odor: Solid white material for Poloxamer 188, 237, 338, 407 and liquid for Poloxamer 124, 331.
Odor: Almost odorless.
Odor threshold: No information found.
pH: 5.0–7.5, in a solution (1 in 40).
Relative density: No information found.
Melting point/freezing point: No information found.
Initial boiling point and boiling range: No information found.
Flash point: No information found.
Auto-ignition temperature: No information found.
Decomposition temperature: No information found.
Upper/lower flammability or explosive limits: No information found.
Vapor pressure: No information found.
Vapor density: No information found.
Evaporation rate: No information found.
Flammability (solid, gas): No information found.
Partition coefficient: n-octanol/water: No information found.
Solubility(ies): Very soluble in water and in ethanol (96 per cent).
Viscosity: No information found.

Stability: It is stable
Conditions to Avoid: Heat.
Incompatibility (Materials to Avoid): Strong oxidizing.
Hazardous Decomposition Products: Carbon monoxide, carbon dioxide, fumes.
Hazardous Polymerization: Will not occur.

Oral LD50: LD50 Oral - rat - > 5000 mg/kg
Carcinogenicity: This product present at levels greater than or equal to 0.1% is identified as probable, possible, or confirmed human carcinogen by IARC, NTP, ACGIH & OSHA.
Mutagenic Effects: No information found.
Developmental Toxicity: No information found.
Reproductive Effects: No information available.

Toxicity: Avoid release into the environment.
Persistence and Degradability: No information found.
Mobility: No information found.
Bioaccumulation/ Accumulation: No information found.
Results of PBT and vPvB assessment: No information found.

Waste Disposal Methods: Dispose Polyvinyl Acetate in accordance with all applicable Federal, State and Local regulations.

Land Transport DOT USA, TDG Canada & ADR/RID Europe: Not dangerous goods.
Sea transport IMDG/IMO: Not dangerous goods.
Air Transport ICAO/IATA: Not dangerous goods.

USA:
SARA 311/312 Hazards: See section 2.
California Prop. 65 Components: Not listed.

Poloxamer Manufacturers, Suppliers, Exporters, Wholesalers:

Plot No. 2900/46&47 + 2900/163to167, GIDC, Ankleshwar, Dist. Bharuch, India
India, USA, UAE
TEL: (Office) 91-22-23774610, 91-22-23723564

If I give you “My Word” Nobody can undo it.
If I sign an “Agreement” my Lawyer will undo it

Our products are for industrial and laboratory use only. The user must test the material before use. We are not dispensing chemists or druggist and do not offer over the counter type (OTC) products for medical use by individuals.

Poloxamer --- Physical Form --- Avg M. Wt.	Wt. (% Oxyethylene)	Unsaturation (mEq/g)
124 ----------- Liquid ----------- 2090–2360	46.7 ± 1.9	0.020 ± 0.008
188 ----------- Solid ------------ 7680–9510	81.8 ± 1.9	0.026 ± 0.008
237 ----------- Solid ------------ 6840–8830	72.4 ± 1.9	0.034 ± 0.008
338 ----------- Solid ----------- 12700– 17400	83.1 ± 1.7	0.031 ± 0.008
407 ----------- Solid ----------- 9840–14600	73.2 ± 1.7	0.048 ± 0.017

Specifications, Properties, Uses, SDS of Poloxamer 124, 188, 237, 331, 338, 407 USP NF BP Ph Eur FCC Food Grade Manufacturer Supplier Exporter Wholesale & Small Packs, CAS Number 9003-11-6.

Poloxamer Manufacturers, Suppliers, Exporters, Wholesalers: