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King of Chemicals Manufacturers Bisoprolol Fumarate and API BP Ph Eur EP USP NF IP JP ChP PPRC Reagent FCC Food Grade Manufacturer |
Specifications, Properties, Uses, SDS of Bisoprolol Fumarate API BP Ph Eur EP IP USP Grade Manufacturer Supplier Exporter Wholesale & Small Packs, CAS Number 104344-23-2. | |
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Muby Chem Pvt. Ltd. is a several decades old group of companies, engaged in manufacturing, supplying, distributing, wholesale supplies of Bisoprolol Fumarate BP Ph Eur EP IP USP Grade for actual users, including retail or small pack supplies for research and development work.
We supply fine and speciality chemicals, pharmaceutical excipients, mineral fortifiers in chemically pure, analytical reagent grade, API IP BP USP Ph Eur EP JP ChP PPRC and other pharmaceutical grade monograph including FCC Food grade chemicals and Nutraceuticals at best prices. We and/or our associated units have all the facilities to supply as per cGMP standard observing good manufacturing practice and good laboratory practice. We can assure low microbial count and also offer a test certificate for the same. We maintain warehouses across USA, India, and UAE. Our group exports to USA, Canada, Mexico, Argentina, Brazil, Chile, Korea, Malaysia, Thailand, Indonesia, Europe, and several other parts of the world. We supply in wholesale container loads to small pack of few grams. Solid products may be specified for it size and shape as desired by the buyer.
Bisoprolol Fumarate CAS Number 104344-23-2
For Properties Specifications Uses of Bisoprolol Fumarate Click Properties, Specifications, Uses, Price, Process of Bisoprolol Fumarate Manufacturer.
For For SDS MSDS Sheet of Bisoprolol Fumarate Click SDS Safety Data Sheet MSDS Sheet of Bisoprolol Fumarate Manufacturer.
The Properties, Specifications, Monograph and Uses of Bisoprolol Fumarate:
Bisoprolol fumarate is primarily used to treat high blood pressure, heart-related chest pain (angina), and chronic heart failure. It belongs to a class of medications called selective beta-blockers. It is used in medecine for High blood pressure, Chest pain, Chronic heart failure, Irregular heart rhythms, Heart attack prevention, etc.
Bisoprolol Fumarate BP Ph Eur Grade:
C40H66N2O12 – 767 --- CAS 104344-23-2
Action and use: Beta-adrenoceptor antagonist.
DEFINITION
(2RS)-1-[4-[[2-(1-Methylethoxy)ethoxy]methyl]phenoxy]-3-[(1-methylethyl)amino]propan-2-ol fumarate.
Content: 99.0 per cent to 101.0 per cent (anhydrous substance).
CHARACTERS
Appearance: White or almost white, slightly hygroscopic powder.
Solubility: Very soluble in water, freely soluble in methanol.
IDENTIFICATION
Infrared absorption spectrophotometry.
TESTS
Related substances: To pass the test by Liquid chromatography.
Water: Maximum 0.5 per cent, determined on 1.000 g.
Sulfated ash: Maximum 0.1 per cent, determined on 1.0 g.
STORAGE
In an airtight container, protected from light.
Bisoprolol Fumarate USP Grade:
(C18H31NO4)2-C4H4O4 --- 766.96
2-Propanol, 1-[4-[[2-(1-methylethoxy)ethoxy]methyl]phenoxy]-3-[(1-methylethyl)amino]-,(±)-, (E)-2-butenedioate (2:1) (salt).
(±)-1-[[α-(2-Isoproproxyethoxy)-p-tolyl]oxy]-3-(isopropylamino)-2-propanol fumarate (2:1) (salt) CAS 104344-23-2
UNII: UR59KN573L
UNII: Y41JS2NL6U
Bisoprolol Fumarate contains not less than 97.5 percent and not more than 102.0 percent of (C18H31NO4)2-C4H4O4 calculated on the anhydrous basis.
Packaging and storage: Preserve in tight, light-resistant containers. Store at controlled room temperature.
Identification:
A: Infrared Absorption.
B: The retention time of the major peak in the chromatogram of the Assay preparation corresponds to that in the chromatogram of the Standard preparation, as obtained in the Assay.
Specific rotation: between –2° and +2°.
Test solution: 10 mg per mL, in methanol.
Water Determination: not more than 0.5%.
Residue on ignition: not more than 0.1%.
Chromatographic purity: To pass the test.
Content of fumaric acid: To pass the test.
Assay: To pass the test by Chromatography.
Bisoprolol Fumarate is also supplied in EP IP Grade.
The MSDS-SDS Hazard Statement of Bisoprolol Fumarate:
Bisoprolol Fumarate or Bisoprolol Hemifumarate SDS, Safety Data Sheet
MSDS Sheet, Material Safety Data Sheet
1. Product Identification
Product Name/Synonyms: Bisoprolol Fumarate or Bisoprolol Hemifumarate.
CAS No.: 104344-23-2
EINECS EC Number: 600-557-5
Molecular Weight: 766.96
Chemical Formula: (C18H31NO4 )2-C4H4O4
Relevant uses and uses advised against (if any): Industrial Manufacturing.
Suppliers: As per letterhead.
2. Hazards Identification
GHS, Globally Harmonized System Classification in accordance with 29 CFR 1910
Classification according to Regulation (EC) No 1272/2008
Acute toxicity, oral Category 4
Labeling according to Regulation (EC) No 1272/2008
GHS Label Elements Harmful |
Signal Words: Warning
Hazard statements:
H302: Harmful if swallowed.
Precautionary statements:
P262: Do not get in eyes, on skin, or on clothing.
P264: Wash skin thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P270: Do not eat, drink or smoke when using this product.
P330: Rinse mouth.
P362: Take off contaminated clothing and wash before reuse.
P301+312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell.
P332+313: If skin irritation occurs: Get medical advice/attention.
P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+P313: If eye irritation persists: Get medical advice/ attention.
3. Composition/Information on Ingredients
Product Name/Synonyms: Bisoprolol Fumarate or Bisoprolol Hemifumarate.
CAS No.: 104344-23-2
EINECS EC Number: 600-557-5
4. First Aid Measures
Inhalation:Remove to fresh air. Give oxygen if breathing is difficult; give artificial respiration if breathing has stopped. Keep person warm and quiet; get medical attention.
Ingestion: Induce vomiting immediately as directed by medical personnel. Never give anything by mouth to an unconscious person.
Skin Contact: Immediately flush skin with plenty of soap and water for at least 15 minutes. Remove contaminated clothing and shoes. Wash clothing before reusing. Thoroughly clean shoes before reusing them. Get medical attention if irritation develops.
Eye Contact: Immediately flush eyes with plenty of water for at least 15 minutes, lifting upper and lower eyelids occasionally. Get medical attention.
Notes to Physician: Treat symptomatically.
5. Fire Fighting Measures
Fire: It is not considered to be a fire hazard. However, it will burn at high temperature.
Fire Extinguishing Media: Use water spray, alcohol-resistant foam, dry chemicals, or carbon dioxide. Avoid solid water jets. Use water spray to cool fire-exposed containers.
Special hazards arising from the substance or mixture: Carbon oxides, Nitrogen oxides (NOx), Fumes.
Special Information: In the event of a fire, wear full protective clothing and NIOSH-approved self-contained breathing apparatus with full face piece.
6. Accidental Release Measures
Personal precautions, protective equipment, and emergency procedures: Use personal protective equipment. Ventilate area of leak or spill. Avoid breathing dust/fumes/gas/mist/vapors/spray. Use individual protective equipment (waterproof boots, suitable protective clothing, safety glasses, etc.).
Environmental precautions: Do not let the product enter drains, soil, or water sources.
Methods and materials used for containment, cleanup procedures and Storage: Contain spilled material. Pick up spills and place them in a suitable container for reclamation or disposal, using a method that does not generate dust.
7. Handling and Storage
Precautions for safe handling: Apply according to good manufacturing and industrial hygiene practices. Ensure proper ventilation. Wear personal protective equipment. Avoid ingestion and inhalation. Wash thoroughly after handling it. Do not drink, eat, or smoke while handling. Avoid contact with skin, eyes, and clothing. Minimize dust generation. Avoid breathing dust/fumes/gas/mist/vapors/spray. Keep container tightly closed. Avoid ingestion and inhalation. Use individual protective equipment (waterproof boots, suitable protective clothing, safety glasses, etc.).
Conditions for safe storage, including any incompatibilities: Store in cool, dry, and ventilated area away from heat sources and protected from sunlight in tightly closed original containers. Keep air contact to a minimum. Do not leave the material container open. Store protected from heat, sparks and ignition sources and incompatible materials. Avoid inhalation of dust/mist/vapor. Do not store with incompatible materials like strong oxidizing agents. Storage: Room temperature. Protected from light. Recommended in a cool and dark place, <15C. Short term shipping may be ambient.
8. Exposure Controls/Personal Protection
Airborne Exposure Limits: None established.
Ventilation System: In general, dilution ventilation is a satisfactory health hazard control for this substance. However, if conditions of use create discomfort for the worker, use a local exhaust.
Personal Respirators (NIOSH Approved): Not expected to require personal respirator usage. For conditions of use where exposure to dust or mist is apparent and engineering controls are not feasible, a particulate respirator (NIOSH type N95 or better filters) may be worn.
Skin Protection:Wear protective gloves and clean body-covering clothing.
Eye Protection: Use chemical safety goggles and/or full-face shield where dusting or splashing of solutions is possible. Maintain eye wash fountain and quick-drench facilities in work area.
9. Physical and Chemical Properties
Appearance: White or almost white, slightly hygroscopic powder.
Odor: No data found.
Odor threshold: No data found.
pH: No data found.
Relative density: No data found.
Boiling Point: No data found.
Melting Point: No data found.
Flash point: No data found.
Auto-ignition temperature: No data found.
Decomposition temperature: No data found.
Upper/lower flammability or explosive limits: No data found.
Vapor pressure: No data found.
Vapor density: No data found.
Evaporation rate: No data found.
Flammability (solid, gas): No data found.
Partition coefficient: n-octanol/water: No data found.
Solubility: Very soluble in water, freely soluble in methanol.
Viscosity: No data found.
10. Stability and Reactivity
Stability: Stable under ordinary conditions of use and storage.
Hazardous Decomposition Products: May produce oxides of nitrogen and carbon along with fumes when heated to decomposition.
Hazardous Polymerization: Will not occur.
Incompatibilities: Strong oxidizing agents.
Conditions to Avoid: Heat, flame, ignition sources, dusting, and incompatibles.
11. Toxicological Information
Toxicity Data: LD50 (Rat): 940 mg/kg.
Carcinogenic Effects: Not a reported carcinogen by IARC, NTP, ACGIH, OSHA.
Mutagenic Effects: No data found.
Reproductive Effects: No data found.
Developmental Effects: No data found.
Environmental Fate: No data found.
Persistence and degradability: Unlikely to persist due to water solubility.
Bioaccumulative potential: No data found.
Mobility in soil: Likely to be mobile due to water solubility.
PBT and vPvB assessment: Not PBT or vPvB.
13. Disposal Considerations
Whatever cannot be saved for recovery, or recycling should be managed in an appropriate and approved waste disposal facility. Follow all the pollution control rules.
14. Transport Information
Land Transport DOT USA, TDG Canada & ADR/RID Europe: Not regulated.
Sea Transport IMDG/IMO: Not regulated.
Air Transport IATA/ICAO: Not regulated.
15. Regulatory Information
USA:
SARA 311/312 Hazardous Categorization: See section 2.
California Proposition 65: Not listed.
16. Other Information
Disclaimer:
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Our company provides this MSDS sheet in good faith but makes no representation as to its comprehensiveness or accuracy. This SDS sheet is intended only as a guide to the appropriate precautionary handling of the material by a properly trained person using this product. The above information has been compiled from various sources and has the possibility of discrepancy and being out-dated information. Individuals receiving the information must exercise their independent judgment and do further search in determining its appropriateness for a particular purpose. In no case shall our company be liable to loss or damages by the product user.
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Bisoprolol Fumarate Manufacturers, Suppliers, Exporters, Wholesalers:
King of Chemicals manufacturers
Plot No. 2900/46&47 + 2900/163to167, GIDC, Ankleshwar, Dist. Bharuch, India
India, USA, UAE
TEL: (Office) 91-22-65290111
email: info@kingofchemicals.com
Copyright and Usual Disclaimer is Applicable --- November 12, 2026
If I give you “My Word” Nobody can undo it.
If I sign an “Agreement” my Lawyer will undo it
Our products are for industrial and laboratory use only. The user must test the material before use. We are not despensing chemists or druggist and do not offer over the counter type (OTC) products for medical use by individuals.
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