Specifications, Uses, SDS of Carmellose Calcium Manufacturers

	King of Chemicals Manufacturers
Specifications, Properties, Uses, SDS of Carmellose Calcium or Carboxymethylcellulose Calcium USP BP Ph Eur EP JP IP Grade Manufacturer Supplier Exporter Wholesale & Small Packs, CAS Number 9050-04-8.
King of Chemicals has several associated companies having accreditations like cGMP, GLP - FDA Approved Good Manufacturing Practice and Good Laboratory Practice of WHO standard, ISO-9001, ISO-14001, ISO/IEC 17025, ISO ISO-45000, HACCP, FSSC 220000, FSSAI, "REACH" Registered, Kosher & Halal Certified. e-CTD and DMF support can be made available if needed. We offer USP NF BP Ph Eur EP IP JP Analytical Reagent FCC Food Grade Chemicals & Nutraceuticals.

Muby Chem Pvt. Ltd. is a several decades old group of companies, engaged in manufacturing, supplying, distributing, wholesale supplies of Carmellose Calcium or Carboxymethylcellulose Calcium USP BP Ph Eur EP JP IP Grade for actual users, including retail or small pack supplies for research and development work.

We supply fine and speciality chemicals, pharmaceutical excipients, mineral fortifiers in chemically pure, analytical reagent grade, IP BP USP Ph Eur EP JP and other pharmaceutical grade monograph including FCC Food grade chemicals and Nutraceuticals at best prices. We and/or our associated units have all the facilities to supply as per cGMP standard observing good manufacturing practice and good laboratory practice. We can assure low microbial count and also offer a test certificate for the same. We maintain warehouses across USA, India, and UAE. Our group exports to USA, Canada, Mexico, Argentina, Brazil, Chile, Korea, Malaysia, Thailand, Indonesia, Europe, and several other parts of the world. We supply in wholesale container loads to small pack of few grams. Solid products may be specified for it size and shape as desired by the buyer.

The Properties, Specifications, Monograph and Uses of Carmellose Calcium or Carboxymethylcellulose Calcium:

Carmellose Calcium BP Ph Eur Grade Specifications
Ph Eur --- CAS 9050-04-8
Action and use: Excipient in pharmaceutical products; bulk laxative.

CHARACTERS
Appearance: White or yellowish-white powder, hygroscopic after drying.
Solubility: Practically insoluble in acetone, in alcohol and in toluene. It swells with water to form a suspension.

IDENTIFICATION
A. Shake 0.1 g thoroughly with 10 ml of water. Add 2 ml of dilute sodium hydroxide solution and allow to stand for 10 min (solution A). Dilute 1 ml of solution A to 5 ml with water. To 0.05 ml add 0.5 ml of a 0.5 g/l solution of chromotropic acid, sodium salt in a 75 per cent m/m solution of sulphuric acid and heat on a water-bath for 10 min. A reddish-violet colour develops.
B. Shake 5 ml of solution A obtained in identification test A with 10 ml of acetone. A white, flocculent precipitate is produced.
C. Shake 5 ml of solution A obtained in identification test A with 1 ml of ferric chloride solution. A brown, flocculent precipitate is formed.
D. Ignite 1 g and dissolve the residue in a mixture of 5 ml of acetic acid and 10 ml of water. Filter if necessary and boil the filtrate for a few minutes. Cool and neutralise with dilute ammonia. The solution gives reaction of calcium.

TESTS
Solution S: Shake 1.0 g with 50 ml of distilled water, add 5 ml of dilute sodium hydroxide solution and dilute to 100 ml with distilled water.
Alkalinity: Shake 1.0 g thoroughly with 50 ml of carbon dioxide-free water and add 0.05 ml of PhPh solution R . No red colour develops.
Chlorides: Maximum 0.36 per cent.
Sulphates: Maximum 1 per cent.
Heavy metals: Maximum 20 ppm.
Loss on drying: Maximum 10.0 per cent, determined on 1.000 g by drying in an oven at 105C for 4 h.
Sulphated ash: 10.0 per cent to 20.0 per cent, determined on 1.0 g in a platinum crucible.

Carboxymethylcellulose Calcium USP Grade Specifications:
Cellulose, carboxymethyl ether, calcium salt;
Cellulose carboxymethyl ether calcium salt CAS 9050-04-8
UNII: UTY7PDF93L

DEFINITION
Carboxymethylcellulose Calcium is the calcium salt of a polycarboxymethyl ether of cellulose.

IDENTIFICATION
A. Procedure
Sample solution: Shake thoroughly 0.1 g of Carboxymethylcellulose Calcium with 10 mL of water, followed by 2 mL of 1 N sodium hydroxide, and allow to stand for 10 min. [Note— Save the unused portion of the Sample solution for use in Identification tests B and C.]
Analysis: To 1 mL of the Sample solution add water to make 5 mL. To 1 drop of the resulting solution, add 0.5 mL of chromotropic acid, and heat in a water bath for 10 min.
Acceptance criteria: A red-purple color develops.
B. Procedure
Analysis: Shake 5 mL of the Sample solution prepared in Identification test A with 10 mL of acetone.
Acceptance criteria: A white, flocculent precipitate is formed.
C. Procedure
Analysis: Shake 5 mL of the Sample solution prepared in Identification test A with 1 mL of ferric chloride.
Acceptance criteria: A brown, flocculent precipitate is formed.
D. Identification Tests—General:
Analysis: Ignite 1 g to ash, dissolve the residue in 10 mL of water and 5 mL of 6 N acetic acid, and filter, if necessary. Boil the filtrate, cool, and neutralize with 6 N ammonium hydroxide.
Acceptance criteria: Meets the requirements.

Residue on Ignition: 10.0%–20.0%; use 1.0 g, previously dried.
Chloride and Sulfate: To pass the test.
Chloride and Sulfate: To pass the test.
Alkalinity: Shake thoroughly 1.0 g with 50 mL of freshly boiled and cooled water and add 2 drops of PhPh: no red color develops.
Loss on Drying: Dry a sample at 105C for 4 h: it loses NMT 10.0% of its weight.

The MSDS-SDS Hazard Statement of Carmellose Calcium or Carboxymethylcellulose Calcium:

Carmellose Calcium or Carboxymethylcellulose Calcium SDS GHS, Safety Data Sheet
MSDS Sheet, Material Safety Data Sheet 04-Feb-24

Product Name & Other Names: Carmellose Calcium or Carboxymethylcellulose Calcium or Calcium salt of a partly O-carboxymethylated cellulose.
CAS Number: 9050-04-8
EINECS EC Code: 618-566-8
Relevant uses and uses advised against (if any): Industrial Manufacturing.

GHS, Globally Harmonized System Classification in accordance with 29 CFR 1910
Hazard Class and Category Code(s), Regulation (EC) No 1272/2008 (CLP)

Not a hazardous substance or mixture according to Regulation (EC) No. 1272/2008.
This substance is not classified as dangerous according to Directive 67/548/EEC.

Precautionary statements:
P261: Avoid breathing dust/fume/gas/mist/vapors/spray.
P262: Do not get in eyes, on skin, or on clothing.
P281: Use personal protective equipment as required.
P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+313: If eye irritation persists get medical advice/attention.

Product Name & Other Names: Carmellose Calcium or Carboxymethylcellulose Calcium or Calcium Salt of a partly O-carboxymethylated cellulose.
CAS Number: 9050-04-8
EINECS EC Code: 618-566-8

Skin: Rinse with water. Soap may be used. Seek Medical Aid.
Eyes: Wash eyes with plenty of water for at least 15 minutes, lifting lids occasionally. Seek Medical Aid.
Inhalation: Remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen.
Ingestion: If swallowed, induce vomiting immediately after giving two glasses of water. Never give anything by mouth to an unconscious person.

Flammability of the Product: Non-flammable. However, it can burn at higher temperature.
Products of Combustion: Oxides of Carbon and Calcium.
Fire Fighting Media and Instructions: Use water spray, alcohol-resistant foam, dry chemical, or carbon dioxide. Wear self-contained breathing apparatus for firefighting if necessary.

Personal precautions, protective equipment, and emergency procedures: Ventilate area of leak or spill. Avoid breathing dust/fumes/gas/mist/vapors/spray. Use individual protective equipment (waterproof boots, suitable protective clothing, safety glasses, etc.). Restrict unprotected personnel from the area. Prevent any contact with hot surfaces. Do not approach facing the wind.
Environmental precautions: Do not let the product enter drains, soil, or water sources.
Methods and materials used for containment Cleanup procedures and Storage: Contain spilled material. Cover with an inert, non-combustible absorbent material, (e.g. sand, earth, diatomaceous earth, vermiculite). Vacuum or sweep-up and remove to an approved disposal container. Finish cleaning by spreading water on the contaminated surface and allow to evacuate as per law.

Precautions for safe handling: Apply according to good manufacturing and industrial hygiene practices. Ensure proper ventilation. In case of insufficient ventilation, wear suitable respiratory equipment. Wash thoroughly after handling. Do not drink, eat, or smoke while handling. Avoid contact with skin, eyes, and clothing. Minimize dust generation. Avoid breathing dust/fumes/gas/mist/vapors/spray. Keep container tightly closed. Avoid ingestion and inhalation. Use individual protective equipment (waterproof boots, suitable protective clothing, safety glasses, etc.).
Conditions for safe storage, including any incompatibilities: Store in cool, dry, and ventilated area away from heat sources and protected from sunlight in tightly closed original container. Keep air contact to a minimum. Store protected from heat, sparks and ignition sources and incompatible materials. Avoid contact with skin and eyes. Avoid inhalation of dust/mist/vapor. Do not store with incompatible materials like strong oxidizing agents and acids.

Engineering Controls: Use process enclosures, local exhaust ventilation, or other engineering controls to keep airborne levels low.
Personal Protection: Safety glasses. Lab coat. Dust respirator. Be sure to use an approved/certified respirator or equivalent Gloves.
Personal Protection in Case of a Large Spill: Splash goggles. Full suit. Dust respirator. Boots. Gloves. A self-contained breathing apparatus should be used to avoid inhalation of the product. Suggested protective clothing might not be sufficient; consult a specialist BEFORE handling this product.

Appearance: Solid off-white powder.
Odor: Odorless.
Odor threshold: Not applicable.
pH (5% soln/water): <7.
Relative density: No data found.
Melting point/freezing point: No data found.
Initial boiling point and boiling range: No data found.
Flash point: No data found.
Auto-ignition temperature: No data found.
Decomposition temperature: No data found.
Upper/lower flammability or explosive limits: No data found.
Vapor pressure: No data found.
Vapor density: No data found.
Evaporation rate: No data found.
Flammability (solid, gas): No data found.
Partition coefficient: n-octanol/water: No data found.
Solubility(ies): Slightly soluble in water.
Viscosity: No data found.

Stability: It is stable in room temperature in closed containers under normal storage & handling.
Conditions of instability: Incompatible materials, Moisture
Incompatibility with various substances: Avoid high temperatures, sparks, open flames and moisture. Avoid contact with strong oxidizing agents and acids.
Polymerization: Will not occur.

LD50 Oral - Rat - 4400 mg/kg
Carcinogenic Effects: Not a reported carcinogen by IARC, NTP, ACGIH, OSHA.
Mutagenic Effects: No data found.
Teratogenic Effects: No data found.
Developmental Toxicity: No data found.
Reproductive Effects: No data found.

Toxicity to fish: No data found.
Persistence and Degradability: No data found.
Mobility: No data found.
Bioaccumulation/ Accumulation: No data found.
Results of PBT and vPvB assessment: No data found.

Waste Disposal: Waste must be disposed of in accordance with federal, state and local environmental control regulations.

Land Transport DOT USA TDG Canada & ADR/RID Europe: Not dangerous goods.
Sea Transport IMO/IMDG: Not dangerous goods.
Air Transport ICAO/IATA: Not dangerous goods.

USA:
SARA 311/312 Hazards: See section 2.
California Prop. 65 Components: This product does not contain any chemicals known to State of California to cause cancer, birth defects, or any other reproductive harm.

DISCLAIMER: The information and recommendations set forth herein are presented in good faith and believed correct as of the date hereof. It is compiled from various sources, and it is not necessarily all inclusive nor fully adequate in every circumstance. In addition, these suggestions should not be confused with nor followed in violation of applicable laws, regulations, rules, or insurance requirements applicable. This SDS MSDS sheet is intended only as a guide to the appropriate precautionary handling of the material by a professionally trained person using this product. Individuals receiving the information must exercise their independent judgment in determining its appropriateness for a particular purpose. This shall not constitute a guarantee for any specific product features and shall not establish a legally valid contractual relationship. In no case shall our company be liable to loss or damages by the product user.

Carmellose Calcium or Carboxymethylcellulose Calcium Manufacturers, Suppliers, Exporters, Wholesalers:

Plot No. 2900/46&47 + 2900/163to167, GIDC, Ankleshwar, Dist. Bharuch, India
India, USA, UAE
TEL: (Office) 91-22-23774610, 91-22-23723564

If I give you “My Word” Nobody can undo it.
If I sign an “Agreement” my Lawyer will undo it

Our products are for industrial and laboratory use only. The user must test the material before use. We are not dispensing chemists or druggist and do not offer over the counter type (OTC) products for medical use by individuals.

Specifications, Properties, Uses, SDS of Carmellose Calcium or Carboxymethylcellulose Calcium USP BP Ph Eur EP JP IP Grade Manufacturer Supplier Exporter Wholesale & Small Packs, CAS Number 9050-04-8.

Carmellose Calcium or Carboxymethylcellulose Calcium Manufacturers, Suppliers, Exporters, Wholesalers: